STRINGSTRING
SETDB1 SETDB1 MTHFR MTHFR EZH1 EZH1 FAM172A FAM172A SIRT1 SIRT1 LOC102387697 LOC102387697 MBD3 MBD3 LMNB1 LMNB1 LOXL2 LOXL2 ZNFX1 ZNFX1 SMCHD1 SMCHD1 SETD7 SETD7 LOC102375843 LOC102375843 LOC102375593 LOC102375593 BEND3 BEND3 UBR2 UBR2 ZDBF2 ZDBF2 POLE3 POLE3 LOC102384538 LOC102384538 DOT1L DOT1L DNMT3L DNMT3L LOC112548070 LOC112548070 HELLS HELLS LOXL3 LOXL3 LMNB2 LMNB2 RRP8 RRP8 BAHD1 BAHD1 SIRT6 SIRT6 MBD2 MBD2 MECOM MECOM HAT1 HAT1 SPTY2D1 SPTY2D1 DNMT1 DNMT1 RIF1 RIF1 EZH2 EZH2 LOC102387029 LOC102387029 PPM1D PPM1D RB1 RB1 PRDM16 PRDM16 LOC102380189 LOC102380189 LOC112551734 LOC112551734 CENPV CENPV LOC102381753 LOC102381753 LOC102370910 LOC102370910 NRM NRM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SETDB1Histone-lysine N-methyltransferase SETDB1 isoform X4. (1349 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (649 aa)
EZH1Histone-lysine N-methyltransferase EZH1. (746 aa)
FAM172AProtein FAM172A. (297 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (557 aa)
LOC102387697Protein FAM172A. (158 aa)
MBD3methyl-CpG-binding domain protein 3. (277 aa)
LMNB1lamin-B1; Belongs to the intermediate filament family. (560 aa)
LOXL2Lysyl oxidase homolog 2 isoform X1. (613 aa)
ZNFX1NFX1-type zinc finger-containing protein 1. (1210 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1. (1974 aa)
SETD7Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. (366 aa)
LOC102375843prelamin-A/C-like; Belongs to the intermediate filament family. (594 aa)
LOC102375593prelamin-A/C-like. (238 aa)
BEND3BEN domain-containing protein 3 isoform X1. (834 aa)
UBR2E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1754 aa)
ZDBF2DBF4-type zinc finger-containing protein 2 isoform X1. (1059 aa)
POLE3DNA polymerase epsilon subunit 3. (143 aa)
LOC102384538lamin-L(III)-like isoform X1; Belongs to the intermediate filament family. (491 aa)
DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specific. (1745 aa)
DNMT3LDNA (Cytosine-5)-methyltransferase 3-like. (418 aa)
LOC112548070Keratin-associated protein 10-7-like. (362 aa)
HELLSLymphoid-specific helicase. (736 aa)
LOXL3Lysyl oxidase homolog 3. (661 aa)
LMNB2lamin-B2 isoform X1; Belongs to the intermediate filament family. (539 aa)
RRP8Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (76 aa)
BAHD1Bromo adjacent homology domain-containing 1 protein. (854 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (285 aa)
MBD2methyl-CpG-binding domain protein 2 isoform X1. (273 aa)
MECOMMDS1 and EVI1 complex locus protein isoform X1. (1241 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (433 aa)
SPTY2D1Protein SPT2 homolog. (681 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1555 aa)
RIF1Telomere-associated protein RIF1. (2334 aa)
EZH2Histone-lysine N-methyltransferase EZH2 isoform X1. (834 aa)
LOC102387029Lysyl oxidase homolog 2-like. (193 aa)
PPM1DProtein phosphatase 1D isoform X1. (460 aa)
RB1Retinoblastoma-associated protein isoform X1. (905 aa)
PRDM16PR domain zinc finger protein 16 isoform X11. (1281 aa)
LOC102380189Histone-lysine N-methyltransferase SETDB2. (1206 aa)
LOC112551734lamin-A-like; Belongs to the intermediate filament family. (268 aa)
CENPVLOW QUALITY PROTEIN: centromere protein V. (229 aa)
LOC102381753Uncharacterized protein. (386 aa)
LOC102370910lamin-A-like; Belongs to the intermediate filament family. (722 aa)
NRMNurim. (176 aa)
Your Current Organism:
Alligator sinensis
NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494
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