STRINGSTRING
CENPV CENPV LOC102388045 LOC102388045 TGFA TGFA WIZ WIZ RPTOR RPTOR IGF2 IGF2 NRM NRM FGF8 FGF8 RCC2 RCC2 MAD2L1BP MAD2L1BP PCID2 PCID2 NCAPG2 NCAPG2 CEP295 CEP295 MAD2L1 MAD2L1 CCND1 CCND1 E2F8 E2F8 CDC73 CDC73 THOC5 THOC5 CDC27 CDC27 LOC102378831 LOC102378831 DYNC1H1 DYNC1H1 CEP120 CEP120 ANAPC7 ANAPC7 CHEK2 CHEK2 CCND3 CCND3 ECT2 ECT2 GPSM2 GPSM2 SMC5 SMC5 CUL3 CUL3 FBXO42 FBXO42 SMC4 SMC4 CPSF3 CPSF3 MAP10 MAP10 TFDP1 TFDP1 CDT1 CDT1 XRCC3 XRCC3 CDC42 CDC42 SLF1 SLF1 ANXA1 ANXA1 SMPD3 SMPD3 NDC80 NDC80 DRD3 DRD3 CDC25B CDC25B UBXN2B UBXN2B CUL4B CUL4B RRM2B RRM2B GEN1 GEN1 CDC7 CDC7 KIF23 KIF23 CDK1 CDK1 ATRX ATRX CDC16 CDC16 NCAPH2 NCAPH2 TPR TPR LOC102380660 LOC102380660 APP APP KLHL18 KLHL18 EDN1 EDN1 LOC102382887 LOC102382887 DRD2 DRD2 NCAPG NCAPG PAGR1 PAGR1 ANAPC11 ANAPC11 LOC102376770 LOC102376770 NCAPH NCAPH KMT2E KMT2E PLRG1 PLRG1 GIPC1 GIPC1 RACGAP1 RACGAP1 NSMCE2 NSMCE2 MAP3K20 MAP3K20 PBK PBK CDCA5 CDCA5 LOC102388290 LOC102388290 MAD1L1 MAD1L1 MEPCE MEPCE LOC102378924 LOC102378924 LOC102381382 LOC102381382 E2F7 E2F7 PLK4 PLK4 MED1 MED1 KIF14 KIF14 FEN1 FEN1 PDGFB PDGFB LOC106722550 LOC106722550 RRM1 RRM1 LOC102373658 LOC102373658 STIL STIL PPP1R10 PPP1R10 PAF1 PAF1 BHMG1 BHMG1 RGCC RGCC NUMA1 NUMA1 CDC25A CDC25A LOC102369595 LOC102369595 LOC112547978 LOC112547978 CDC23 CDC23 GLI1 GLI1 USP19 USP19 LOC102372256 LOC102372256 CDC25C CDC25C LOC102388803 LOC102388803 AIF1 AIF1 PPP1R35 PPP1R35 DDR2 DDR2 CXCR5 CXCR5 DBF4 DBF4 SIRT2 SIRT2 LOC102384171 LOC102384171 CUL4A CUL4A ATAD5 ATAD5 CDC14A CDC14A CDC14B CDC14B LOC102386077 LOC102386077 ADAM17 ADAM17 BTC BTC ANKRD17 ANKRD17 SASS6 SASS6 LRP5 LRP5 ANAPC5 ANAPC5 EREG EREG EPGN EPGN STXBP4 STXBP4 RAD51B RAD51B GIPC2 GIPC2 ROCK2 ROCK2 RRM2 RRM2 SLF2 SLF2 CDC6 CDC6 LOC102368693 LOC102368693 STOX1 STOX1 INO80 INO80 LOC102369134 LOC102369134 STRA8 STRA8 DBF4B DBF4B HOXA13 HOXA13 CIT CIT SMC2 SMC2 DDX11 DDX11 CCND2 CCND2 THOC1 THOC1 GIPC3 GIPC3 CSPP1 CSPP1 RAD51C RAD51C RB1 RB1 PIWIL2 PIWIL2 DYNC1LI1 DYNC1LI1 FAM178B FAM178B TAS1R2 TAS1R2 NSFL1C NSFL1C RANBP1 RANBP1 SPAG5 SPAG5 POLDIP2 POLDIP2 LSM11 LSM11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CENPVLOW QUALITY PROTEIN: centromere protein V. (229 aa)
LOC102388045Protein FAM83D-like. (407 aa)
TGFAProtransforming growth factor alpha isoform X1. (190 aa)
WIZProtein Wiz isoform X1. (2136 aa)
RPTORRegulatory-associated protein of mTOR. (1310 aa)
IGF2Insulin-like growth factor II isoform X2. (268 aa)
NRMNurim. (176 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
RCC2Protein RCC2 isoform X1. (474 aa)
MAD2L1BPMAD2L1-binding protein. (203 aa)
PCID2PCI domain-containing protein 2 isoform X1. (399 aa)
NCAPG2Condensin-2 complex subunit G2 isoform X1. (1158 aa)
CEP295Centrosomal protein of 295 kDa. (1878 aa)
MAD2L1Mitotic spindle assembly checkpoint protein MAD2A. (205 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (292 aa)
E2F8Transcription factor E2F8 isoform X1. (937 aa)
CDC73Parafibromin. (488 aa)
THOC5THO complex subunit 5 homolog isoform X1. (683 aa)
CDC27Cell division cycle protein 27 homolog isoform X1. (863 aa)
LOC102378831Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
DYNC1H1Cytoplasmic dynein 1 heavy chain 1. (4600 aa)
CEP120Centrosomal protein of 120 kDa. (833 aa)
ANAPC7Anaphase-promoting complex subunit 7 isoform X1. (565 aa)
CHEK2Serine/threonine-protein kinase Chk2. (441 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (238 aa)
ECT2Protein ECT2 isoform X1. (990 aa)
GPSM2G-protein-signaling modulator 2. (665 aa)
SMC5Structural maintenance of chromosomes protein 5. (1068 aa)
CUL3Cullin-3 isoform X1; Belongs to the cullin family. (746 aa)
FBXO42F-box only protein 42 isoform X1. (715 aa)
SMC4Structural maintenance of chromosomes protein 4. (322 aa)
CPSF3Cleavage and polyadenylation specificity factor subunit 3 isoform X1. (691 aa)
MAP10Microtubule-associated protein 10. (839 aa)
TFDP1Transcription factor. (412 aa)
CDT1DNA replication factor Cdt1. (516 aa)
XRCC3DNA repair protein XRCC3. (352 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
SLF1SMC5-SMC6 complex localization factor protein 1. (930 aa)
ANXA1Annexin. (342 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (665 aa)
NDC80Kinetochore protein NDC80 homolog isoform X1. (640 aa)
DRD3D(3) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (423 aa)
CDC25BM-phase inducer phosphatase 2 isoform X1. (521 aa)
UBXN2BUBX domain-containing protein 2B. (410 aa)
CUL4Bcullin-4B; Belongs to the cullin family. (891 aa)
RRM2BRibonucleoside-diphosphate reductase subunit M2 B isoform X1. (380 aa)
GEN1Flap endonuclease GEN homolog 1. (944 aa)
CDC7Cell division cycle 7-related protein kinase. (563 aa)
KIF23Kinesin-like protein KIF23; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1006 aa)
CDK1LOW QUALITY PROTEIN: cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (311 aa)
ATRXTranscriptional regulator ATRX isoform X1. (2604 aa)
CDC16Cell division cycle protein 16 homolog isoform X1. (690 aa)
NCAPH2LOW QUALITY PROTEIN: condensin-2 complex subunit H2. (580 aa)
TPRNucleoprotein TPR isoform X1. (2367 aa)
LOC102380660Centrosomal protein of 120 kDa-like. (160 aa)
APPAmyloid-beta A4 protein isoform X1. (716 aa)
KLHL18Kelch-like protein 18. (602 aa)
EDN1Endothelin-1. (200 aa)
LOC102382887Supervillin-like. (1056 aa)
DRD2D(2) dopamine receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
NCAPGLOW QUALITY PROTEIN: condensin complex subunit 3. (1033 aa)
PAGR1PAXIP1-associated glutamate-rich protein 1 isoform X1. (214 aa)
ANAPC11Anaphase-promoting complex subunit 11. (69 aa)
LOC102376770Structural maintenance of chromosomes protein 4-like. (960 aa)
NCAPHCondensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (802 aa)
KMT2EInactive histone-lysine N-methyltransferase 2E isoform X1. (1856 aa)
PLRG1Pleiotropic regulator 1. (515 aa)
GIPC1PDZ domain-containing protein GIPC1. (552 aa)
RACGAP1Rac GTPase-activating protein 1 isoform X1. (608 aa)
NSMCE2E3 SUMO-protein ligase NSE2. (237 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20 isoform X3. (807 aa)
PBKLymphokine-activated killer T-cell-originated protein kinase isoform X1. (325 aa)
CDCA5Sororin. (260 aa)
LOC102388290Protein FAM83D-like. (211 aa)
MAD1L1Mitotic spindle assembly checkpoint protein MAD1. (554 aa)
MEPCE7SK snRNA methylphosphate capping enzyme. (585 aa)
LOC102378924Mitogen-activated protein kinase. (557 aa)
LOC102381382Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (652 aa)
E2F7LOW QUALITY PROTEIN: transcription factor E2F7. (940 aa)
PLK4Serine/threonine-protein kinase PLK4. (968 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1565 aa)
KIF14Kinesin-like protein KIF14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1660 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (382 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (276 aa)
LOC106722550LOW QUALITY PROTEIN: mitogen-activated protein kinase 15-like. (312 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (779 aa)
LOC102373658Mitotic spindle assembly checkpoint protein MAD1-like. (171 aa)
STILSCL-interrupting locus protein isoform X1. (1326 aa)
PPP1R10Serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1. (882 aa)
PAF1RNA polymerase II-associated factor 1 homolog. (359 aa)
BHMG1Basic helix-loop-helix and HMG box domain-containing protein 1. (173 aa)
RGCCRegulator of cell cycle RGCC. (131 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2212 aa)
CDC25ALOW QUALITY PROTEIN: M-phase inducer phosphatase 1. (521 aa)
LOC102369595Interleukin-1; Belongs to the IL-1 family. (279 aa)
LOC112547978Interleukin-1. (241 aa)
CDC23Cell division cycle protein 23 homolog. (570 aa)
GLI1Zinc finger protein GLI1. (747 aa)
USP19LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 19. (2609 aa)
LOC102372256LOW QUALITY PROTEIN: rac GTPase-activating protein 1-like. (385 aa)
CDC25CM-phase inducer phosphatase 3 isoform X1. (414 aa)
LOC102388803Flocculation protein FLO11-like. (683 aa)
AIF1Allograft inflammatory factor 1. (148 aa)
PPP1R35Protein phosphatase 1 regulatory subunit 35. (284 aa)
DDR2LOW QUALITY PROTEIN: discoidin domain-containing receptor 2. (861 aa)
CXCR5C-X-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (372 aa)
DBF4LOW QUALITY PROTEIN: protein DBF4 homolog A. (696 aa)
SIRT2LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-2. (324 aa)
LOC102384171Mdm2-binding protein-like isoform X1. (614 aa)
CUL4Acullin-4A; Belongs to the cullin family. (614 aa)
ATAD5ATPase family AAA domain-containing protein 5. (1833 aa)
CDC14ADual specificity protein phosphatase CDC14A isoform X1. (537 aa)
CDC14BDual specificity protein phosphatase CDC14B isoform X1. (511 aa)
LOC102386077Spindle assembly abnormal protein 6 homolog. (638 aa)
ADAM17Disintegrin and metalloproteinase domain-containing protein 17 isoform X1. (803 aa)
BTCProbetacellulin. (175 aa)
ANKRD17Ankyrin repeat domain-containing protein 17 isoform X1. (2508 aa)
SASS6Spindle assembly abnormal protein 6 homolog isoform X1. (626 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1593 aa)
ANAPC5Anaphase-promoting complex subunit 5 isoform X1. (772 aa)
EREGProepiregulin. (173 aa)
EPGNEpigen isoform X1. (171 aa)
STXBP4Syntaxin-binding protein 4 isoform X1. (793 aa)
RAD51BDNA repair protein RAD51 homolog 2 isoform X1. (380 aa)
GIPC2PDZ domain-containing protein GIPC2. (258 aa)
ROCK2Rho-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1455 aa)
RRM2Ribonucleoside-diphosphate reductase subunit M2. (596 aa)
SLF2SMC5-SMC6 complex localization factor protein 2 isoform X1. (1206 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (549 aa)
LOC102368693Supervillin isoform X1. (1356 aa)
STOX1LOW QUALITY PROTEIN: storkhead-box protein 1. (385 aa)
INO80DNA helicase INO80 isoform X1. (1580 aa)
LOC102369134Mdm2-binding protein isoform X1. (328 aa)
STRA8LOW QUALITY PROTEIN: stimulated by retinoic acid gene 8 protein homolog. (496 aa)
DBF4BProtein DBF4 homolog B. (771 aa)
HOXA13LOW QUALITY PROTEIN: homeobox protein Hox-A13. (316 aa)
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2081 aa)
SMC2Structural maintenance of chromosomes protein. (1202 aa)
DDX11LOW QUALITY PROTEIN: ATP-dependent DNA helicase DDX11. (873 aa)
CCND2G1/S-specific cyclin-D2 isoform X1; Belongs to the cyclin family. (552 aa)
THOC1THO complex subunit 1. (667 aa)
GIPC3PDZ domain-containing protein GIPC3 isoform X1. (335 aa)
CSPP1Centrosome and spindle pole-associated protein 1 isoform X1. (1238 aa)
RAD51CDNA repair protein RAD51 homolog 3. (296 aa)
RB1Retinoblastoma-associated protein isoform X1. (905 aa)
PIWIL2Piwi-like protein 2; Belongs to the argonaute family. (969 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (470 aa)
FAM178BLOW QUALITY PROTEIN: protein FAM178B. (834 aa)
TAS1R2Taste receptor type 1 member 2 isoform X1. (874 aa)
NSFL1CNSFL1 cofactor p47. (396 aa)
RANBP1Ran-specific GTPase-activating protein. (213 aa)
SPAG5Sperm-associated antigen 5. (828 aa)
POLDIP2Polymerase delta-interacting protein 2. (387 aa)
LSM11U7 snRNA-associated Sm-like protein LSm11. (222 aa)
Your Current Organism:
Alligator sinensis
NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494
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