STRINGSTRING
SIX4 SIX4 HGF HGF WNT2B WNT2B STOX1 STOX1 ESR1 ESR1 MMRN2 MMRN2 GATA3 GATA3 SULF1 SULF1 SIX2 SIX2 GREM1 GREM1 SOX8 SOX8 LGR4 LGR4 AR AR WNT5A WNT5A SIRT6 SIRT6 LOC106721843 LOC106721843 LIF LIF LOC102387076 LOC102387076 LOC102378738 LOC102378738 PIK3CD PIK3CD MDK MDK AGT AGT WNT5B WNT5B GDNF GDNF HOXD13 HOXD13 HOXB7 HOXB7 FGF1 FGF1 WNT2 WNT2 NKD1 NKD1 SMO SMO BTBD7 BTBD7 RNF207 RNF207 FKBPL FKBPL CTNNB1 CTNNB1 NTN4 NTN4 TGFB1 TGFB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIX4Homeobox protein SIX4. (510 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (681 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (299 aa)
STOX1LOW QUALITY PROTEIN: storkhead-box protein 1. (385 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (627 aa)
MMRN2LOW QUALITY PROTEIN: multimerin-2. (1011 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3. (385 aa)
SULF1Extracellular sulfatase Sulf-1 isoform X1. (1125 aa)
SIX2Homeobox protein SIX2. (259 aa)
GREM1Gremlin. (184 aa)
SOX8Transcription factor SOX-8. (417 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1. (887 aa)
ARAndrogen receptor isoform X2. (430 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (377 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (285 aa)
LOC106721843Netrin-4-like isoform X1. (647 aa)
LIFLeukemia inhibitory factor isoform X1. (211 aa)
LOC102387076LOW QUALITY PROTEIN: homeobox protein six1. (173 aa)
LOC102378738Tumor necrosis factor. (231 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
MDKMidkine isoform X1. (142 aa)
AGTAngiotensinogen; Belongs to the serpin family. (457 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (260 aa)
GDNFGlial cell line-derived neurotrophic factor. (159 aa)
HOXD13Homeobox protein Hox-D13. (239 aa)
HOXB7Homeobox protein Hox-B7. (217 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
NKD1Protein naked cuticle homolog 1 isoform X1. (591 aa)
SMOSmoothened homolog isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (803 aa)
BTBD7BTB/POZ domain-containing protein 7. (1121 aa)
RNF207RING finger protein 207 isoform X1. (648 aa)
FKBPLFK506-binding protein-like. (335 aa)
CTNNB1Catenin beta-1. (784 aa)
NTN4Netrin-4 isoform X1. (590 aa)
TGFB1Transforming growth factor beta-1. (235 aa)
Your Current Organism:
Alligator sinensis
NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494
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