(5 nodes) Glycoprotein hormone receptor family network (Alligator sinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FSHR	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
	LGR5	Leucine-rich repeat-containing G-protein coupled receptor 5. (883 aa)
	LGR4	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1. (887 aa)
	TSHR	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (717 aa)
	LGR6	Leucine-rich repeat-containing G-protein coupled receptor 6 isoform X1. (964 aa)

Your Current Organism:

Alligator sinensis

NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LGR4	LGR5	A0A3Q0G933	A0A3Q0GU30	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1.	Leucine-rich repeat-containing G-protein coupled receptor 5.	0.967
LGR4	LGR6	A0A3Q0G933	A0A1U8DAF6	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1.	Leucine-rich repeat-containing G-protein coupled receptor 6 isoform X1.	0.922
LGR5	LGR4	A0A3Q0GU30	A0A3Q0G933	Leucine-rich repeat-containing G-protein coupled receptor 5.	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1.	0.967
LGR5	LGR6	A0A3Q0GU30	A0A1U8DAF6	Leucine-rich repeat-containing G-protein coupled receptor 5.	Leucine-rich repeat-containing G-protein coupled receptor 6 isoform X1.	0.924
LGR6	LGR4	A0A1U8DAF6	A0A3Q0G933	Leucine-rich repeat-containing G-protein coupled receptor 6 isoform X1.	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1.	0.922
LGR6	LGR5	A0A1U8DAF6	A0A3Q0GU30	Leucine-rich repeat-containing G-protein coupled receptor 6 isoform X1.	Leucine-rich repeat-containing G-protein coupled receptor 5.	0.924