(35 nodes) Toll/interleukin-1 receptor homology (TIR) domain superfamily network (Alligator sinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102368346	Toll-like receptor 2 type-2; Belongs to the Toll-like receptor family. (793 aa)
	SIGIRR	Single Ig IL-1-related receptor isoform X1. (561 aa)
	LOC102370354	Toll-like receptor 13. (997 aa)
	LOC102378124	Toll-like receptor 13; Belongs to the Toll-like receptor family. (954 aa)
	TLR2	Toll-like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
	LOC102375359	Toll-like receptor 8. (1040 aa)
	LOC102373745	Toll-like receptor 1; Belongs to the Toll-like receptor family. (801 aa)
	TLR7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1050 aa)
	LOC102383113	Toll-like receptor 2. (875 aa)
	LOC102377912	Interleukin-1 receptor type 1. (566 aa)
	SARM1	Sterile alpha and TIR motif-containing protein 1. (718 aa)
	LOC102371494	Toll-like receptor 1. (652 aa)
	IL1RAP	Interleukin-1 receptor accessory protein isoform X1. (684 aa)
	IL18RAP	Interleukin-18 receptor accessory protein. (585 aa)
	MYD88	Myeloid differentiation primary response protein MyD88. (211 aa)
	LOC102384063	Toll-like receptor 2; Belongs to the Toll-like receptor family. (837 aa)
	LOC102387656	Toll-like receptor 13. (969 aa)
	IL1RAPL1	Interleukin-1 receptor accessory protein-like 1. (445 aa)
	LOC102378316	Interleukin-1 receptor-like 2 isoform X1. (585 aa)
	TLR3	Toll-like receptor 3 isoform X1; Belongs to the Toll-like receptor family. (905 aa)
	LOC112548286	Uncharacterized protein LOC112548286. (456 aa)
	LOC112548287	Toll-like receptor 10 isoform X1. (243 aa)
	LOC112548285	Uncharacterized protein LOC112548285. (484 aa)
	LOC112548964	Uncharacterized protein LOC112548964. (433 aa)
	TICAM1	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (694 aa)
	TLR8	Toll-like receptor 8 isoform X1; Belongs to the Toll-like receptor family. (1090 aa)
	TIRAP	Toll/interleukin-1 receptor domain-containing adapter protein isoform X1. (219 aa)
	BANK1	B-cell scaffold protein with ankyrin repeats. (699 aa)
	LOC102378217	Uncharacterized protein LOC102378217; Belongs to the EMP24/GP25L family. (433 aa)
	TLR4	LOW QUALITY PROTEIN: toll-like receptor 4; Belongs to the Toll-like receptor family. (849 aa)
	TLR5	Toll-like receptor 5 isoform X1; Belongs to the Toll-like receptor family. (870 aa)
	IL17RD	Interleukin-17 receptor D isoform X3. (611 aa)
	IL18R1	Interleukin-18 receptor 1. (413 aa)
	IL1RL1	Interleukin-1 receptor-like 1 isoform X1. (555 aa)
	IL1RAPL2	X-linked interleukin-1 receptor accessory protein-like 2. (686 aa)

Your Current Organism:

Alligator sinensis

NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL18R1	IL18RAP	A0A3Q0HA85	A0A1U7SJD9	Interleukin-18 receptor 1.	Interleukin-18 receptor accessory protein.	0.800
IL18R1	IL1RAP	A0A3Q0HA85	A0A1U7SE64	Interleukin-18 receptor 1.	Interleukin-1 receptor accessory protein isoform X1.	0.573
IL18R1	SIGIRR	A0A3Q0HA85	A0A1U7R8N6	Interleukin-18 receptor 1.	Single Ig IL-1-related receptor isoform X1.	0.603
IL18RAP	IL18R1	A0A1U7SJD9	A0A3Q0HA85	Interleukin-18 receptor accessory protein.	Interleukin-18 receptor 1.	0.800
IL1RAP	IL18R1	A0A1U7SE64	A0A3Q0HA85	Interleukin-1 receptor accessory protein isoform X1.	Interleukin-18 receptor 1.	0.573
IL1RAP	IL1RL1	A0A1U7SE64	A0A3Q0HBH3	Interleukin-1 receptor accessory protein isoform X1.	Interleukin-1 receptor-like 1 isoform X1.	0.968
IL1RAP	LOC102377912	A0A1U7SE64	A0A1U7S5H5	Interleukin-1 receptor accessory protein isoform X1.	Interleukin-1 receptor type 1.	0.990
IL1RAP	LOC102378316	A0A1U7SE64	A0A1U8DFJ9	Interleukin-1 receptor accessory protein isoform X1.	Interleukin-1 receptor-like 2 isoform X1.	0.980
IL1RAP	MYD88	A0A1U7SE64	A0A1U7SKF5	Interleukin-1 receptor accessory protein isoform X1.	Myeloid differentiation primary response protein MyD88.	0.979
IL1RL1	IL1RAP	A0A3Q0HBH3	A0A1U7SE64	Interleukin-1 receptor-like 1 isoform X1.	Interleukin-1 receptor accessory protein isoform X1.	0.968
IL1RL1	MYD88	A0A3Q0HBH3	A0A1U7SKF5	Interleukin-1 receptor-like 1 isoform X1.	Myeloid differentiation primary response protein MyD88.	0.763
LOC102368346	LOC102371494	A0A1U7RFQ8	A0A1U7SC90	Toll-like receptor 2 type-2; Belongs to the Toll-like receptor family.	Toll-like receptor 1.	0.904
LOC102368346	LOC102373745	A0A1U7RFQ8	A0A1U7RU44	Toll-like receptor 2 type-2; Belongs to the Toll-like receptor family.	Toll-like receptor 1; Belongs to the Toll-like receptor family.	0.904
LOC102368346	MYD88	A0A1U7RFQ8	A0A1U7SKF5	Toll-like receptor 2 type-2; Belongs to the Toll-like receptor family.	Myeloid differentiation primary response protein MyD88.	0.937
LOC102368346	TIRAP	A0A1U7RFQ8	A0A3Q0GFW6	Toll-like receptor 2 type-2; Belongs to the Toll-like receptor family.	Toll/interleukin-1 receptor domain-containing adapter protein isoform X1.	0.929
LOC102368346	TLR4	A0A1U7RFQ8	A0A3Q0GXQ9	Toll-like receptor 2 type-2; Belongs to the Toll-like receptor family.	LOW QUALITY PROTEIN: toll-like receptor 4; Belongs to the Toll-like receptor family.	0.528
LOC102370354	LOC102378217	A0A1U7RBQ9	A0A3Q0GL00	Toll-like receptor 13.	Uncharacterized protein LOC102378217; Belongs to the EMP24/GP25L family.	0.509
LOC102370354	MYD88	A0A1U7RBQ9	A0A1U7SKF5	Toll-like receptor 13.	Myeloid differentiation primary response protein MyD88.	0.597
LOC102370354	TICAM1	A0A1U7RBQ9	A0A3Q0G1N7	Toll-like receptor 13.	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines.	0.416
LOC102371494	LOC102368346	A0A1U7SC90	A0A1U7RFQ8	Toll-like receptor 1.	Toll-like receptor 2 type-2; Belongs to the Toll-like receptor family.	0.904