(32 nodes) Recognition of DNA damage by PCNA-containing replication complex network (Alligator sinensis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	WDR48	WD repeat-containing protein 48 isoform X1. (677 aa)
	UBB	polyubiquitin-B. (233 aa)
	RFC2	Replication factor C subunit 2 isoform X1. (370 aa)
	POLE4	DNA polymerase epsilon subunit 4. (144 aa)
	DDB1	DNA damage-binding protein 1. (1130 aa)
	MEIOB	Meiosis-specific with OB domain-containing protein isoform X1. (477 aa)
	RAD18	E3 ubiquitin-protein ligase RAD18 isoform X1. (489 aa)
	POLD1	DNA polymerase. (1198 aa)
	ATAD5	ATPase family AAA domain-containing protein 5. (1833 aa)
	CUL4A	cullin-4A; Belongs to the cullin family. (614 aa)
	RFC4	Replication factor C subunit 4. (303 aa)
	LOC102378721	RCC1 and BTB domain-containing protein 1 isoform X1. (531 aa)
	USP1	Ubiquitin carboxyl-terminal hydrolase. (793 aa)
	POLD2	DNA polymerase delta subunit 2 isoform X1. (468 aa)
	UBA52	ubiquitin-60S ribosomal protein L40. (104 aa)
	POLE3	DNA polymerase epsilon subunit 3. (143 aa)
	POLD3	DNA polymerase delta subunit 3 isoform X1. (455 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2244 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (603 aa)
	RCBTB2	RCC1 and BTB domain-containing protein 2 isoform X1. (552 aa)
	RPA3	Replication protein A 14 kDa subunit isoform X1. (120 aa)
	DTL	Denticleless protein homolog isoform X1. (736 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
	RFC1	Replication factor C subunit 1. (1143 aa)
	RBX1	E3 ubiquitin-protein ligase RBX1 isoform X1. (108 aa)
	KXD1	kxDL motif-containing protein 1. (176 aa)
	RFC5	Replication factor C subunit 5 isoform X1. (336 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (513 aa)
	CUL4B	cullin-4B; Belongs to the cullin family. (891 aa)
	UBC	polyubiquitin-C. (381 aa)
	RPS27A	ubiquitin-40S ribosomal protein S27a. (156 aa)

Your Current Organism:

Alligator sinensis

NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	CUL4A	A0A3Q0FXM6	A0A3Q0FXB4	ATPase family AAA domain-containing protein 5.	cullin-4A; Belongs to the cullin family.	0.541
ATAD5	CUL4B	A0A3Q0FXM6	A0A1U7RZH6	ATPase family AAA domain-containing protein 5.	cullin-4B; Belongs to the cullin family.	0.541
ATAD5	DDB1	A0A3Q0FXM6	A0A3Q0GSF5	ATPase family AAA domain-containing protein 5.	DNA damage-binding protein 1.	0.603
ATAD5	DTL	A0A3Q0FXM6	A0A1U7SE21	ATPase family AAA domain-containing protein 5.	Denticleless protein homolog isoform X1.	0.805
ATAD5	MEIOB	A0A3Q0FXM6	A0A3Q0GQK1	ATPase family AAA domain-containing protein 5.	Meiosis-specific with OB domain-containing protein isoform X1.	0.729
ATAD5	PCNA	A0A3Q0FXM6	A0A1U7SCI4	ATPase family AAA domain-containing protein 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.972
ATAD5	POLD1	A0A3Q0FXM6	A0A3Q0FZY1	ATPase family AAA domain-containing protein 5.	DNA polymerase.	0.804
ATAD5	POLD2	A0A3Q0FXM6	A0A1U8DCD1	ATPase family AAA domain-containing protein 5.	DNA polymerase delta subunit 2 isoform X1.	0.684
ATAD5	POLD3	A0A3Q0FXM6	A0A1U8D875	ATPase family AAA domain-containing protein 5.	DNA polymerase delta subunit 3 isoform X1.	0.626
ATAD5	POLE	A0A3Q0FXM6	A0A1U7SMU9	ATPase family AAA domain-containing protein 5.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.883
ATAD5	POLE2	A0A3Q0FXM6	A0A1U7S3N0	ATPase family AAA domain-containing protein 5.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.828
ATAD5	POLE3	A0A3Q0FXM6	A0A1U8DB90	ATPase family AAA domain-containing protein 5.	DNA polymerase epsilon subunit 3.	0.762
ATAD5	POLE4	A0A3Q0FXM6	A0A3Q0GW63	ATPase family AAA domain-containing protein 5.	DNA polymerase epsilon subunit 4.	0.724
ATAD5	RAD18	A0A3Q0FXM6	A0A3Q0GMA8	ATPase family AAA domain-containing protein 5.	E3 ubiquitin-protein ligase RAD18 isoform X1.	0.809
ATAD5	RFC1	A0A3Q0FXM6	A0A1U7SC85	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 1.	0.701
ATAD5	RFC2	A0A3Q0FXM6	A0A3Q0H7H7	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 2 isoform X1.	0.979
ATAD5	RFC3	A0A3Q0FXM6	A0A1U7S626	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 3.	0.988
ATAD5	RFC4	A0A3Q0FXM6	A0A1U8E038	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 4.	0.987
ATAD5	RFC5	A0A3Q0FXM6	A0A1U7SB46	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 5 isoform X1.	0.984
ATAD5	RPA1	A0A3Q0FXM6	A0A1U7SJE8	ATPase family AAA domain-containing protein 5.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.729