STRINGSTRING
PSMA7 PSMA7 PSMC5 PSMC5 PSMA8 PSMA8 PLCB2 PLCB2 SMURF2 SMURF2 RPS27A RPS27A GNB5 GNB5 WNT11 WNT11 PSMB3 PSMB3 FHDC1 FHDC1 PDE6B PDE6B PSMA2 PSMA2 PRKCG PRKCG PSMD9 PSMD9 NLK NLK UBC UBC PSMA6 PSMA6 PSMA4 PSMA4 PRICKLE4 PRICKLE4 WNT5B WNT5B PSMD6 PSMD6 GNGT2 GNGT2 DAAM2 DAAM2 PSMD14 PSMD14 SMURF1 SMURF1 RAC2 RAC2 DAAM1 DAAM1 WDR92 WDR92 PSMD7 PSMD7 PSMF1 PSMF1 PSMC6 PSMC6 LOC102372061 LOC102372061 CTNNB1 CTNNB1 GNG12 GNG12 LOC102381860 LOC102381860 LOC102379476 LOC102379476 KXD1 KXD1 PSMC3 PSMC3 PDE6G PDE6G FZD3 FZD3 PSMB6 PSMB6 LOC102367890 LOC102367890 PSME2 PSME2 MAP3K20 MAP3K20 WNT1 WNT1 AP2S1 AP2S1 PSMD13 PSMD13 FZD2 FZD2 LOC102380219 LOC102380219 ROR2 ROR2 PSMC4 PSMC4 FZD7 FZD7 WNT4 WNT4 PSMA3 PSMA3 PPP3CC PPP3CC FZD5 FZD5 LOC106722594 LOC106722594 GNG13 GNG13 PSMC2 PSMC2 PSMD4 PSMD4 GNG7 GNG7 NFATC1 NFATC1 LOC106722823 LOC106722823 PSMB7 PSMB7 ROR1 ROR1 PSMB5 PSMB5 DVL2 DVL2 PSMD5 PSMD5 PSMB4 PSMB4 LOC112548330 LOC112548330 LOC102368918 LOC102368918 LOC102381531 LOC102381531 PLCB3 PLCB3 RAC3 RAC3 CLTB CLTB PRKCA PRKCA PSMD12 PSMD12 DVL3 DVL3 AP2M1 AP2M1 PSMA1 PSMA1 TCF7 TCF7 AP2A1 AP2A1 GNB4 GNB4 DVL1 DVL1 WNT5A WNT5A LOC102383099 LOC102383099 MAP3K7 MAP3K7 PRICKLE2 PRICKLE2 PSME3 PSME3 PSME4 PSME4 CLTA CLTA PSMD1 PSMD1 PPP3R1 PPP3R1 TCF7L2 TCF7L2 PLCB1 PLCB1 PSMD3 PSMD3 PDE6H PDE6H GNG2 GNG2 LOC102384525 LOC102384525 PRICKLE1 PRICKLE1 PSMB2 PSMB2 PRKCB PRKCB PSMD11 PSMD11 LOC102385776 LOC102385776 NFAT5 NFAT5 PSMC1 PSMC1 FZD6 FZD6 FZD1 FZD1 GNG5 GNG5 LOC102379219 LOC102379219 PDE6C PDE6C GNB1 GNB1 LEF1 LEF1 TCF7L1 TCF7L1 PRICKLE3 PRICKLE3 GNG4 GNG4 FZD4 FZD4 UBB UBB PSMD10 PSMD10 PSMA5 PSMA5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMA7Proteasome subunit alpha type. (248 aa)
PSMC526S proteasome regulatory subunit 8; Belongs to the AAA ATPase family. (411 aa)
PSMA8Proteasome subunit alpha type. (249 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1207 aa)
SMURF2E3 ubiquitin-protein ligase. (748 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5 isoform X1. (353 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PSMB3Proteasome subunit beta. (290 aa)
FHDC1FH2 domain-containing protein 1. (1133 aa)
PDE6BPhosphodiesterase. (834 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (689 aa)
PSMD926S proteasome non-ATPase regulatory subunit 9 isoform X1. (205 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (525 aa)
UBCpolyubiquitin-C. (381 aa)
PSMA6Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (382 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
PRICKLE4Prickle-like protein 4 isoform X1. (549 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (260 aa)
PSMD626S proteasome non-ATPase regulatory subunit 6. (317 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
DAAM2Disheveled-associated activator of morphogenesis 2. (278 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14 isoform X1. (310 aa)
SMURF1E3 ubiquitin-protein ligase SMURF1. (718 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
DAAM1Disheveled-associated activator of morphogenesis 1. (1070 aa)
WDR92WD repeat-containing protein 92. (359 aa)
PSMD726S proteasome non-ATPase regulatory subunit 7. (297 aa)
PSMF1Proteasome inhibitor PI31 subunit. (190 aa)
PSMC626S proteasome regulatory subunit 10B; Belongs to the AAA ATPase family. (373 aa)
LOC102372061Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
CTNNB1Catenin beta-1. (784 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
LOC102381860Proteasome subunit beta. (277 aa)
LOC102379476Proteasome subunit beta type-9-like. (280 aa)
KXD1kxDL motif-containing protein 1. (176 aa)
PSMC326S proteasome regulatory subunit 6A; Belongs to the AAA ATPase family. (422 aa)
PDE6GRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma. (90 aa)
FZD3LOW QUALITY PROTEIN: frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (670 aa)
PSMB6Proteasome subunit beta. (227 aa)
LOC102367890Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
PSME2Proteasome activator complex subunit 2. (242 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20 isoform X3. (807 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (341 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13. (376 aa)
FZD2LOW QUALITY PROTEIN: frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (635 aa)
LOC102380219Partitioning defective 6 homolog alpha-like. (367 aa)
ROR2LOW QUALITY PROTEIN: tyrosine-protein kinase transmembrane receptor ROR2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (913 aa)
PSMC426S proteasome regulatory subunit 6B; Belongs to the AAA ATPase family. (402 aa)
FZD7LOW QUALITY PROTEIN: frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (323 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
PSMA3Proteasome subunit alpha type. (260 aa)
PPP3CCSerine/threonine-protein phosphatase. (438 aa)
FZD5LOW QUALITY PROTEIN: frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (510 aa)
LOC106722594Frizzled-8-like; Belongs to the G-protein coupled receptor Fz/Smo family. (155 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
PSMC226S proteasome regulatory subunit 7; Belongs to the AAA ATPase family. (428 aa)
PSMD426S proteasome non-ATPase regulatory subunit 4 isoform X1. (408 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (636 aa)
LOC106722823Proteasome subunit beta type-8-like isoform X1. (160 aa)
PSMB7Proteasome subunit beta type-7. (211 aa)
ROR1LOW QUALITY PROTEIN: inactive tyrosine-protein kinase transmembrane receptor ROR1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (885 aa)
PSMB5Proteasome subunit beta. (249 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2. (614 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5. (481 aa)
PSMB4LOW QUALITY PROTEIN: proteasome subunit beta type-4. (305 aa)
LOC112548330FH2 domain-containing protein 1-like. (123 aa)
LOC102368918Nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1. (301 aa)
LOC102381531AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (957 aa)
PLCB3Phosphoinositide phospholipase C. (795 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (282 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (362 aa)
PRKCANon-specific serine/threonine protein kinase. (552 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12 isoform X2. (404 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (711 aa)
AP2M1AP-2 complex subunit mu isoform X1; Belongs to the adaptor complexes medium subunit family. (437 aa)
PSMA1Proteasome endopeptidase complex. (265 aa)
TCF7Transcription factor 7 isoform X1. (482 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (969 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (663 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (377 aa)
LOC102383099formin-H-like. (738 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7 isoform X1. (571 aa)
PRICKLE2Prickle-like protein 2 isoform X1. (863 aa)
PSME3Proteasome activator complex subunit 3. (193 aa)
PSME4Proteasome activator complex subunit 4 isoform X1. (1848 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (208 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
PPP3R1Calcineurin subunit B type 1. (160 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (584 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (485 aa)
PDE6HRetinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma. (85 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (93 aa)
LOC102384525Ras-related C3 botulinum toxin substrate 1 isoform X1. (224 aa)
PRICKLE1Prickle-like protein 1 isoform X1. (833 aa)
PSMB2Proteasome subunit beta. (167 aa)
PRKCBNon-specific serine/threonine protein kinase. (544 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11. (408 aa)
LOC102385776Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (128 aa)
NFAT5Nuclear factor of activated T-cells 5 isoform X1. (1523 aa)
PSMC126S proteasome regulatory subunit 4; Belongs to the AAA ATPase family. (367 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (667 aa)
FZD1LOW QUALITY PROTEIN: frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (405 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (43 aa)
LOC102379219Disheveled-associated activator of morphogenesis 2. (841 aa)
PDE6CPhosphodiesterase. (840 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
LEF1Lymphoid enhancer-binding factor 1. (349 aa)
TCF7L1Transcription factor 7-like 1. (454 aa)
PRICKLE3Prickle planar cell polarity protein 3 isoform X1. (659 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (450 aa)
UBBpolyubiquitin-B. (233 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10. (157 aa)
PSMA5Proteasome endopeptidase complex. (183 aa)
Your Current Organism:
Alligator sinensis
NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494
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