STRINGSTRING
SCML2 SCML2 PSMD1 PSMD1 LOC102370874 LOC102370874 PHC2 PHC2 PSMD3 PSMD3 ESR1 ESR1 PBRM1 PBRM1 DPY30 DPY30 PSMB2 PSMB2 PSMD11 PSMD11 CCND2 CCND2 PRMT8 PRMT8 LOC102382400 LOC102382400 PSMC1 PSMC1 ARID2 ARID2 SIN3B SIN3B LDB2 LDB2 ACTL6B ACTL6B LOC102382167 LOC102382167 TP73 TP73 SCMH1 SCMH1 GATA3 GATA3 LOC102383886 LOC102383886 GATA1 GATA1 MYB MYB PAX2 PAX2 UBB UBB PSMD10 PSMD10 LDB1 LDB1 PSMA5 PSMA5 PSMC5 PSMC5 SETD1B SETD1B PSMA8 PSMA8 LMO2 LMO2 ARID1A ARID1A TAL1 TAL1 CCND1 CCND1 LOC102382262 LOC102382262 GATA2 GATA2 RPS27A RPS27A PSMB3 PSMB3 ASH2L ASH2L PML PML PSMA2 PSMA2 LOC102388444 LOC102388444 LOC102373634 LOC102373634 PSMD9 PSMD9 CDK7 CDK7 CCND3 CCND3 LOC102384725 LOC102384725 UBC UBC PSMA6 PSMA6 ACTL6A ACTL6A SMARCA4 SMARCA4 CCNH CCNH PSMA4 PSMA4 LOC102384030 LOC102384030 ZFPM1 ZFPM1 MNAT1 MNAT1 PSMD6 PSMD6 CTSL CTSL SMARCB1 SMARCB1 PSMA7 PSMA7 PSMD14 PSMD14 LOC102385673 LOC102385673 LOC102387686 LOC102387686 CSNK2A1 CSNK2A1 LOC102375956 LOC102375956 LOC102378535 LOC102378535 PAX5 PAX5 PHC1 PHC1 LOC102384519 LOC102384519 PSMD7 PSMD7 PSMF1 PSMF1 SMARCD1 SMARCD1 LOC102385431 LOC102385431 SIN3A SIN3A PSMC6 PSMC6 LOC102381860 LOC102381860 LOC102379476 LOC102379476 PSMC3 PSMC3 PSMB6 PSMB6 TMEM62 TMEM62 SMARCC1 SMARCC1 LOC102373170 LOC102373170 KMT2E KMT2E CSNK2B CSNK2B ELF2 ELF2 PSME2 PSME2 RNF2 RNF2 PCGF5 PCGF5 PSMD13 PSMD13 LMO3 LMO3 SPI1 SPI1 SMARCD3 SMARCD3 SETD5 SETD5 LOC102379984 LOC102379984 PSMC4 PSMC4 LMO1 LMO1 SOCS4 SOCS4 PSMA3 PSMA3 EP300 EP300 CSNK2A2 CSNK2A2 CLDN5 CLDN5 WDR5 WDR5 UBA52 UBA52 SMARCE1 SMARCE1 RBBP5 RBBP5 LOC102383137 LOC102383137 AUTS2 AUTS2 CREBBP CREBBP CBX6 CBX6 LOC102373194 LOC102373194 PSMC2 PSMC2 RING1 RING1 PSMD4 PSMD4 ITCH ITCH CBX2 CBX2 PSMB7 PSMB7 CBX8 CBX8 KMT2D KMT2D SMARCC2 SMARCC2 KMT2B KMT2B PSMB5 PSMB5 PSMD5 PSMD5 PSMB4 PSMB4 KMT2A KMT2A SETD1A SETD1A SMARCD2 SMARCD2 CBX4 CBX4 PSMD12 PSMD12 ELF1 ELF1 PSMA1 PSMA1 LOC102386995 LOC102386995 CBFB CBFB SPIB SPIB LOC102372873 LOC102372873 PTPN11 PTPN11 HIPK2 HIPK2 KMT2C KMT2C PSME3 PSME3 PSME4 PSME4 ARID1B ARID1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCML2Sex comb on midleg-like protein 2 isoform X1. (735 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
LOC102370874LOW QUALITY PROTEIN: probable global transcription activator SNF2L2. (1406 aa)
PHC2Polyhomeotic-like protein 2 isoform X1. (905 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (485 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (627 aa)
PBRM1Protein polybromo-1 isoform X1. (1711 aa)
DPY30Protein dpy-30 homolog isoform X1. (137 aa)
PSMB2Proteasome subunit beta. (167 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11. (408 aa)
CCND2G1/S-specific cyclin-D2 isoform X1; Belongs to the cyclin family. (552 aa)
PRMT8Protein arginine N-methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (447 aa)
LOC102382400Autism susceptibility gene 2 protein-like. (223 aa)
PSMC126S proteasome regulatory subunit 4; Belongs to the AAA ATPase family. (367 aa)
ARID2AT-rich interactive domain-containing protein 2 isoform X1. (1862 aa)
SIN3BPaired amphipathic helix protein Sin3b isoform X1. (1082 aa)
LDB2LIM domain-binding protein 2 isoform X1. (386 aa)
ACTL6BActin-like protein 6B; Belongs to the actin family. (427 aa)
LOC102382167Uncharacterized protein ZSWIM9-like isoform X1. (554 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (668 aa)
SCMH1Polycomb protein SCMH1 isoform X1. (699 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3. (385 aa)
LOC102383886Paired box protein Pax-8. (418 aa)
GATA1LOW QUALITY PROTEIN: erythroid transcription factor. (323 aa)
MYBTranscriptional activator Myb isoform X1. (764 aa)
PAX2Paired box protein Pax-2. (346 aa)
UBBpolyubiquitin-B. (233 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10. (157 aa)
LDB1LIM domain-binding protein 1 isoform X5. (467 aa)
PSMA5Proteasome endopeptidase complex. (183 aa)
PSMC526S proteasome regulatory subunit 8; Belongs to the AAA ATPase family. (411 aa)
SETD1BHistone-lysine N-methyltransferase SETD1B isoform X1. (2008 aa)
PSMA8Proteasome subunit alpha type. (249 aa)
LMO2Rhombotin-2. (158 aa)
ARID1AAT-rich interactive domain-containing protein 1A. (1897 aa)
TAL1T-cell acute lymphocytic leukemia protein 1 isoform X1. (183 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (292 aa)
LOC102382262Histone H2B; Belongs to the histone H2B family. (126 aa)
GATA2Endothelial transcription factor GATA-2. (309 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
PSMB3Proteasome subunit beta. (290 aa)
ASH2Lset1/Ash2 histone methyltransferase complex subunit ASH2 isoform X2. (495 aa)
PMLProtein PML. (586 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
LOC102388444Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC102373634Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (86 aa)
PSMD926S proteasome non-ATPase regulatory subunit 9 isoform X1. (205 aa)
CDK7Cyclin-dependent kinase 7 isoform X1; Belongs to the protein kinase superfamily. (343 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (238 aa)
LOC102384725Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
UBCpolyubiquitin-C. (381 aa)
PSMA6Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (382 aa)
ACTL6AActin-like protein 6A; Belongs to the actin family. (376 aa)
SMARCA4Transcription activator BRG1 isoform X1. (1650 aa)
CCNHcyclin-H; Belongs to the cyclin family. (254 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
LOC102384030Histone H2B; Belongs to the histone H2B family. (126 aa)
ZFPM1Zinc finger protein ZFPM1 isoform X1. (1137 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
PSMD626S proteasome non-ATPase regulatory subunit 6. (317 aa)
CTSLCathepsin L1; Belongs to the peptidase C1 family. (338 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (386 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14 isoform X1. (310 aa)
LOC102385673Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC102387686Histone H2B; Belongs to the histone H2B family. (126 aa)
CSNK2A1Casein kinase II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (391 aa)
LOC102375956Probable global transcription activator SNF2L2. (202 aa)
LOC102378535Protein PML-like isoform X1. (852 aa)
PAX5LOW QUALITY PROTEIN: paired box protein Pax-5. (402 aa)
PHC1Polyhomeotic-like protein 1. (1002 aa)
LOC102384519Histone H2B; Belongs to the histone H2B family. (126 aa)
PSMD726S proteasome non-ATPase regulatory subunit 7. (297 aa)
PSMF1Proteasome inhibitor PI31 subunit. (190 aa)
SMARCD1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1. (421 aa)
LOC102385431Histone H2B; Belongs to the histone H2B family. (166 aa)
SIN3APaired amphipathic helix protein Sin3a isoform X1. (1279 aa)
PSMC626S proteasome regulatory subunit 10B; Belongs to the AAA ATPase family. (373 aa)
LOC102381860Proteasome subunit beta. (277 aa)
LOC102379476Proteasome subunit beta type-9-like. (280 aa)
PSMC326S proteasome regulatory subunit 6A; Belongs to the AAA ATPase family. (422 aa)
PSMB6Proteasome subunit beta. (227 aa)
TMEM62Transmembrane protein 62 isoform X1. (513 aa)
SMARCC1SWI/SNF complex subunit SMARCC1. (1043 aa)
LOC102373170Histone H2B; Belongs to the histone H2B family. (126 aa)
KMT2EInactive histone-lysine N-methyltransferase 2E isoform X1. (1856 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (242 aa)
ELF2ETS-related transcription factor Elf-2 isoform X1. (593 aa)
PSME2Proteasome activator complex subunit 2. (242 aa)
RNF2LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RING2. (334 aa)
PCGF5Polycomb group RING finger protein 5 isoform X1. (256 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13. (376 aa)
LMO3LIM domain only protein 3. (145 aa)
SPI1Transcription factor PU.1 isoform X1. (266 aa)
SMARCD3SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D. (486 aa)
SETD5LOW QUALITY PROTEIN: SET domain-containing protein 5. (1475 aa)
LOC102379984Histone H2B; Belongs to the histone H2B family. (118 aa)
PSMC426S proteasome regulatory subunit 6B; Belongs to the AAA ATPase family. (402 aa)
LMO1Rhombotin-1 isoform X1. (178 aa)
SOCS4Suppressor of cytokine signaling 4. (435 aa)
PSMA3Proteasome subunit alpha type. (260 aa)
EP300Histone acetyltransferase p300 isoform X1. (2149 aa)
CSNK2A2Casein kinase II subunit alpha' isoform X1; Belongs to the protein kinase superfamily. (323 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (177 aa)
WDR5WD repeat-containing protein 5 isoform X1. (382 aa)
UBA52ubiquitin-60S ribosomal protein L40. (104 aa)
SMARCE1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E, member 1. (433 aa)
RBBP5Retinoblastoma-binding protein 5 isoform X1. (513 aa)
LOC102383137Histone H2A; Belongs to the histone H2A family. (140 aa)
AUTS2Autism susceptibility gene 2 protein. (1067 aa)
CREBBPCREB-binding protein. (2468 aa)
CBX6Chromobox protein homolog 6. (374 aa)
LOC102373194Casein kinase II subunit alpha-like isoform X1; Belongs to the protein kinase superfamily. (392 aa)
PSMC226S proteasome regulatory subunit 7; Belongs to the AAA ATPase family. (428 aa)
RING1E3 ubiquitin-protein ligase RING1. (291 aa)
PSMD426S proteasome non-ATPase regulatory subunit 4 isoform X1. (408 aa)
ITCHE3 ubiquitin-protein ligase. (808 aa)
CBX2Chromobox protein homolog 2. (592 aa)
PSMB7Proteasome subunit beta type-7. (211 aa)
CBX8Chromobox protein homolog 8. (354 aa)
KMT2DLOW QUALITY PROTEIN: histone-lysine N-methyltransferase 2D. (4785 aa)
SMARCC2SWI/SNF complex subunit SMARCC2. (925 aa)
KMT2BLOW QUALITY PROTEIN: histone-lysine N-methyltransferase 2B. (1671 aa)
PSMB5Proteasome subunit beta. (249 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5. (481 aa)
PSMB4LOW QUALITY PROTEIN: proteasome subunit beta type-4. (305 aa)
KMT2AHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3876 aa)
SETD1AHistone-lysine N-methyltransferase SETD1A. (1308 aa)
SMARCD2SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D. (444 aa)
CBX4E3 SUMO-protein ligase CBX4. (456 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12 isoform X2. (404 aa)
ELF1LOW QUALITY PROTEIN: ETS-related transcription factor Elf-1. (619 aa)
PSMA1Proteasome endopeptidase complex. (265 aa)
LOC102386995Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (603 aa)
CBFBCore-binding factor subunit beta isoform X1. (211 aa)
SPIBTranscription factor Spi-B isoform X1. (270 aa)
LOC102372873Protein PML-like isoform X1. (652 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (609 aa)
HIPK2Homeodomain-interacting protein kinase 2 isoform X1. (1225 aa)
KMT2CLOW QUALITY PROTEIN: histone-lysine N-methyltransferase 2C. (4940 aa)
PSME3Proteasome activator complex subunit 3. (193 aa)
PSME4Proteasome activator complex subunit 4 isoform X1. (1848 aa)
ARID1BAT-rich interactive domain-containing protein 1B isoform X1. (1986 aa)
Your Current Organism:
Alligator sinensis
NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494
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