16 items (Alligator sinensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102384773	Hyaluronidase. (507 aa)
	LOC102384522	Hyaluronidase. (470 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
	RACGAP1	Rac GTPase-activating protein 1 isoform X1. (608 aa)
	HYAL3	Hyaluronidase. (505 aa)
	CD4	T-cell surface glycoprotein CD4. (491 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (627 aa)
	EGF	Pro-epidermal growth factor. (1257 aa)
	SPAM1	Hyaluronidase. (570 aa)
	PGR	Progesterone receptor. (338 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (400 aa)
	FOXP3	Forkhead box protein P3 isoform X1. (356 aa)
	LOC102384045	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
	HYAL1	Hyaluronidase. (445 aa)
	HYAL2	Hyaluronidase. (474 aa)
	TOP2A	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1488 aa)

Your Current Organism:

Alligator sinensis

NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	EGF	A0A1U8DZG6	A0A3Q0GQU8	T-cell surface glycoprotein CD4.	Pro-epidermal growth factor.	0.558
CD4	ESR1	A0A1U8DZG6	A0A3Q0GNM7	T-cell surface glycoprotein CD4.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.541
CD4	FOXP3	A0A1U8DZG6	A0A3Q0HBL5	T-cell surface glycoprotein CD4.	Forkhead box protein P3 isoform X1.	0.755
CD4	GAPDH	A0A1U8DZG6	A0A3Q0HB56	T-cell surface glycoprotein CD4.	Glyceraldehyde-3-phosphate dehydrogenase.	0.597
CD4	HYAL3	A0A1U8DZG6	A0A1U8D2F5	T-cell surface glycoprotein CD4.	Hyaluronidase.	0.512
CD4	INS	A0A1U8DZG6	A0A1U7SDF5	T-cell surface glycoprotein CD4.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.732
CD4	LOC102384045	A0A1U8DZG6	A0A1U7RPI8	T-cell surface glycoprotein CD4.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.862
CD4	LOC102384773	A0A1U8DZG6	A0A3Q0GS34	T-cell surface glycoprotein CD4.	Hyaluronidase.	0.429
CD4	SPAM1	A0A1U8DZG6	A0A3Q0GS29	T-cell surface glycoprotein CD4.	Hyaluronidase.	0.429
EGF	CD4	A0A3Q0GQU8	A0A1U8DZG6	Pro-epidermal growth factor.	T-cell surface glycoprotein CD4.	0.558
EGF	ESR1	A0A3Q0GQU8	A0A3Q0GNM7	Pro-epidermal growth factor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.560
EGF	HYAL1	A0A3Q0GQU8	A0A1U7RPT1	Pro-epidermal growth factor.	Hyaluronidase.	0.646
EGF	HYAL2	A0A3Q0GQU8	A0A1U7RTQ6	Pro-epidermal growth factor.	Hyaluronidase.	0.587
EGF	HYAL3	A0A3Q0GQU8	A0A1U8D2F5	Pro-epidermal growth factor.	Hyaluronidase.	0.646
EGF	INS	A0A3Q0GQU8	A0A1U7SDF5	Pro-epidermal growth factor.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.810
EGF	LOC102384045	A0A3Q0GQU8	A0A1U7RPI8	Pro-epidermal growth factor.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.475
EGF	LOC102384522	A0A3Q0GQU8	A0A1U7S2S2	Pro-epidermal growth factor.	Hyaluronidase.	0.646
EGF	LOC102384773	A0A3Q0GQU8	A0A3Q0GS34	Pro-epidermal growth factor.	Hyaluronidase.	0.587
EGF	PGR	A0A3Q0GQU8	A0A3Q0H404	Pro-epidermal growth factor.	Progesterone receptor.	0.468
EGF	SPAM1	A0A3Q0GQU8	A0A3Q0GS29	Pro-epidermal growth factor.	Hyaluronidase.	0.587