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HSPA4 HSPA4 FIGLA FIGLA RSPO1 RSPO1 PCGF2 PCGF2 PCGF1 PCGF1 TRPM4 TRPM4 KDM6B KDM6B CALML6 CALML6 FOXO3 FOXO3 PGR PGR TRPM6 TRPM6 FZD1 FZD1 MAPK9 MAPK9 SRD5A2 SRD5A2 STRA8 STRA8 DLL4 DLL4 ADAD1 ADAD1 EIF1 EIF1 PLCB1 PLCB1 ATF5 ATF5 PLD1 PLD1 MAP3K1 MAP3K1 TRPV4 TRPV4 HSD17B3 HSD17B3 WNT5A WNT5A KCNN1 KCNN1 CIRBP CIRBP ATP2B4 ATP2B4 HNRNPUL1 HNRNPUL1 KDM1A KDM1A PRKCI PRKCI NR5A1 NR5A1 DDIT4 DDIT4 STAT1 STAT1 C2CD2 C2CD2 GCA GCA PDGFB PDGFB CALM1 CALM1 ESR2 ESR2 UBE2J1 UBE2J1 PCGF6 PCGF6 LIG4 LIG4 POMC POMC AMH AMH CALML4 CALML4 AMHR2 AMHR2 CAMKK1 CAMKK1 PLCL2 PLCL2 LOC102369688 LOC102369688 SOX9 SOX9 CACNB3 CACNB3 ATP2B1 ATP2B1 CHMP1A CHMP1A DNAJC28 DNAJC28 CALM3 CALM3 JARID2 JARID2 JAG2 JAG2 S100Z S100Z C2CD2L C2CD2L TERF2IP TERF2IP KDM3B KDM3B IKBKG IKBKG LHX9 LHX9 ALDH1A2 ALDH1A2 RELA RELA BMP7 BMP7 MAP3K8 MAP3K8 MCU MCU CLK4 CLK4 TRPC4 TRPC4 DMRT1 DMRT1 PRDX3 PRDX3 SFRP2 SFRP2 GLRX GLRX GADD45G GADD45G TXNDC11 TXNDC11 HSPB11 HSPB11 KDM2B KDM2B TRPC3 TRPC3 SDF4 SDF4 CALR CALR EGR2 EGR2 HSP90AB1 HSP90AB1 MAPK8 MAPK8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HSPA4Heat shock 70 kDa protein 4 isoform X1. (842 aa)
FIGLAFactor in the germline alpha. (177 aa)
RSPO1R-spondin-1 isoform X1. (261 aa)
PCGF2Polycomb group RING finger protein 2 isoform X1. (333 aa)
PCGF1Polycomb group RING finger protein 1 isoform X1. (222 aa)
TRPM4LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily M member 4. (1152 aa)
KDM6BLOW QUALITY PROTEIN: lysine-specific demethylase 6B. (1098 aa)
CALML6Calmodulin-like protein 6 isoform X1. (190 aa)
FOXO3Forkhead box protein O3. (488 aa)
PGRProgesterone receptor. (338 aa)
TRPM6Transient receptor potential cation channel subfamily M member 6 isoform X1. (2038 aa)
FZD1LOW QUALITY PROTEIN: frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (405 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase 2. (201 aa)
STRA8LOW QUALITY PROTEIN: stimulated by retinoic acid gene 8 protein homolog. (496 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (615 aa)
ADAD1Adenosine deaminase domain-containing protein 1 isoform X1. (597 aa)
EIF1Eukaryotic translation initiation factor 1. (166 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
ATF5Cyclic AMP-dependent transcription factor ATF-5. (376 aa)
PLD1Phospholipase. (1108 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1 isoform X1. (1343 aa)
TRPV4LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (865 aa)
HSD17B3Testosterone 17-beta-dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (313 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (377 aa)
KCNN1Small conductance calcium-activated potassium channel protein 1 isoform X1. (642 aa)
CIRBPCold-inducible RNA-binding protein isoform X1. (173 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1182 aa)
HNRNPUL1Heterogeneous nuclear ribonucleoprotein U-like protein 1. (817 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (751 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (560 aa)
NR5A1Steroidogenic factor 1. (480 aa)
DDIT4DNA damage-inducible transcript 4 protein. (196 aa)
STAT1Signal transducer and activator of transcription. (753 aa)
C2CD2C2 domain-containing protein 2. (618 aa)
GCAGrancalcin. (204 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (276 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (113 aa)
ESR2Estrogen receptor beta isoform X1. (548 aa)
UBE2J1Ubiquitin-conjugating enzyme E2 J1. (332 aa)
PCGF6Polycomb group RING finger protein 6 isoform X1. (327 aa)
LIG4DNA ligase. (914 aa)
POMCPro-opiomelanocortin. (261 aa)
AMHMuellerian-inhibiting factor. (677 aa)
CALML4Calmodulin-like protein 4 isoform X1. (152 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (545 aa)
CAMKK1Calcium/calmodulin-dependent protein kinase kinase 1. (536 aa)
PLCL2Phosphoinositide phospholipase C. (996 aa)
LOC102369688Calmodulin-alpha-like; Belongs to the calmodulin family. (149 aa)
SOX9Transcription factor SOX-9. (494 aa)
CACNB3Voltage-dependent L-type calcium channel subunit beta-3. (473 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (821 aa)
CHMP1ACharged multivesicular body protein 1a. (196 aa)
DNAJC28dnaJ homolog subfamily C member 28. (378 aa)
CALM3Calmodulin-3; Belongs to the calmodulin family. (144 aa)
JARID2LOW QUALITY PROTEIN: protein Jumonji. (1243 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1228 aa)
S100ZProtein S100; Belongs to the S-100 family. (99 aa)
C2CD2LPhospholipid transfer protein C2CD2L isoform X1. (651 aa)
TERF2IPTelomeric repeat-binding factor 2-interacting protein 1 isoform X1. (235 aa)
KDM3BLOW QUALITY PROTEIN: lysine-specific demethylase 3B. (1682 aa)
IKBKGNF-kappa-B essential modulator. (534 aa)
LHX9LIM/homeobox protein Lhx9 isoform X1. (397 aa)
ALDH1A2Retinal dehydrogenase 2 isoform X1; Belongs to the aldehyde dehydrogenase family. (422 aa)
RELATranscription factor p65. (554 aa)
BMP7Bone morphogenetic protein 7 isoform X1. (431 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
MCUCalcium uniporter protein, mitochondrial. (309 aa)
CLK4Dual specificity protein kinase CLK4 isoform X3; Belongs to the protein kinase superfamily. (477 aa)
TRPC4Short transient receptor potential channel 4; Belongs to the transient receptor (TC 1.A.4) family. (975 aa)
DMRT1Doublesex- and mab-3-related transcription factor 1 isoform X1. (363 aa)
PRDX3Thioredoxin-dependent peroxide reductase, mitochondrial. (227 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
GLRXGlutaredoxin-1. (105 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (141 aa)
TXNDC11Thioredoxin domain-containing protein 11 isoform X1. (883 aa)
HSPB11Intraflagellar transport protein 25 homolog. (141 aa)
KDM2BLysine-specific demethylase 2B. (1265 aa)
TRPC3Short transient receptor potential channel 3 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (838 aa)
SDF445 kDa calcium-binding protein. (354 aa)
CALRCalreticulin. (412 aa)
EGR2E3 SUMO-protein ligase EGR2. (357 aa)
HSP90AB1Heat shock protein HSP 90-beta. (729 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
Your Current Organism:
Alligator sinensis
NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494
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