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PLCB2 PLCB2 PIP4K2A PIP4K2A INPP5E INPP5E IMPA1 IMPA1 DGKE DGKE PRKCG PRKCG PI4KA PI4KA MTMR7 MTMR7 SYNJ2 SYNJ2 PIP4K2B PIP4K2B PIK3CD PIK3CD PIK3R1 PIK3R1 PLCZ1 PLCZ1 PLCD3 PLCD3 ITPKA ITPKA PLCG2 PLCG2 LOC102378320 LOC102378320 PLCD1 PLCD1 MTMR8 MTMR8 IP6K3 IP6K3 PIK3C2G PIK3C2G CDS2 CDS2 CALM3 CALM3 PIK3R2 PIK3R2 LOC102369688 LOC102369688 IP6K2 IP6K2 INPP1 INPP1 IMPA2 IMPA2 PIP4K2C PIP4K2C ITPK1 ITPK1 LOC102368100 LOC102368100 CALML4 CALML4 LOC102379727 LOC102379727 IP6K1 IP6K1 PIK3C2B PIK3C2B PIK3CB PIK3CB CALM1 CALM1 PLCB4 PLCB4 PTEN PTEN LOC102368895 LOC102368895 INPP4A INPP4A INPP5D INPP5D DGKB DGKB PLCG1 PLCG1 LOC102369174 LOC102369174 MTMR14 MTMR14 MTMR3 MTMR3 DGKA DGKA PLCE1 PLCE1 PIP4P1 PIP4P1 PLCB3 PLCB3 INPPL1 INPPL1 PRKCA PRKCA LOC112548809 LOC112548809 PIK3CA PIK3CA DGKH DGKH MTMR6 MTMR6 MTMR2 MTMR2 DGKQ DGKQ LOC102375443 LOC102375443 INPP5F INPP5F SACM1L SACM1L PIK3C3 PIK3C3 PLCB1 PLCB1 PIP5K1B PIP5K1B PI4K2B PI4K2B PIK3C2A PIK3C2A IPPK IPPK MTMR1 MTMR1 MTM1 MTM1 ITPR3 ITPR3 DGKK DGKK ITPR1 ITPR1 LOC102380057 LOC102380057 PIP5K1C PIP5K1C PRKCB PRKCB DGKD DGKD DGKZ DGKZ OCRL OCRL PIKFYVE PIKFYVE CALML6 CALML6 PPIP5K1 PPIP5K1 INPP4B INPP4B SYNJ1 SYNJ1 PIP5K1A PIP5K1A DGKI DGKI INPP5B INPP5B LOC102368550 LOC102368550 IPMK IPMK PI4K2A PI4K2A LOC102379301 LOC102379301 ITPKB ITPKB IMPAD1 IMPAD1 MTMR4 MTMR4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1207 aa)
PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1. (347 aa)
INPP5E72 kDa inositol polyphosphate 5-phosphatase. (618 aa)
IMPA1Inositol-1-monophosphatase. (278 aa)
DGKEDiacylglycerol kinase. (570 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (689 aa)
PI4KAPhosphatidylinositol 4-kinase alpha isoform X1; Belongs to the PI3/PI4-kinase family. (2044 aa)
MTMR7Myotubularin-related protein 7. (660 aa)
SYNJ2Synaptojanin-2 isoform X1. (1459 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (370 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
PLCZ1Phosphoinositide phospholipase C. (634 aa)
PLCD3Phosphoinositide phospholipase C. (754 aa)
ITPKAKinase; Belongs to the inositol phosphokinase (IPK) family. (333 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
LOC102378320Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (343 aa)
PLCD1Phosphoinositide phospholipase C. (771 aa)
MTMR8Myotubularin-related protein 8. (632 aa)
IP6K3Kinase; Belongs to the inositol phosphokinase (IPK) family. (415 aa)
PIK3C2GPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; Belongs to the PI3/PI4-kinase family. (1010 aa)
CDS2Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (442 aa)
CALM3Calmodulin-3; Belongs to the calmodulin family. (144 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (727 aa)
LOC102369688Calmodulin-alpha-like; Belongs to the calmodulin family. (149 aa)
IP6K2Kinase; Belongs to the inositol phosphokinase (IPK) family. (424 aa)
INPP1Inositol polyphosphate 1-phosphatase. (376 aa)
IMPA2Inositol-1-monophosphatase. (274 aa)
PIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma. (342 aa)
ITPK1Inositol-tetrakisphosphate 1-kinase. (407 aa)
LOC102368100Type I inositol 1,4,5-trisphosphate 5-phosphatase-like. (157 aa)
CALML4Calmodulin-like protein 4 isoform X1. (152 aa)
LOC102379727Inositol 1,4,5-trisphosphate receptor type 2. (1420 aa)
IP6K1Kinase; Belongs to the inositol phosphokinase (IPK) family. (434 aa)
PIK3C2BPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1; Belongs to the PI3/PI4-kinase family. (1637 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (113 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
PTENannotation not available (206 aa)
LOC1023688951-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1295 aa)
INPP4AType I inositol 3,4-bisphosphate 4-phosphatase isoform X1. (976 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1. (1209 aa)
DGKBDiacylglycerol kinase. (735 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1282 aa)
LOC102369174LOW QUALITY PROTEIN: phosphatidylinositol 4-kinase beta-like. (511 aa)
MTMR14Myotubularin-related protein 14. (513 aa)
MTMR3Myotubularin-related protein 3 isoform X1. (1224 aa)
DGKADiacylglycerol kinase. (771 aa)
PLCE11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1. (2319 aa)
PIP4P1Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (197 aa)
PLCB3Phosphoinositide phospholipase C. (795 aa)
INPPL1Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2. (1267 aa)
PRKCANon-specific serine/threonine protein kinase. (552 aa)
LOC112548809Inositol-tetrakisphosphate 1-kinase-like. (195 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
DGKHDiacylglycerol kinase. (1078 aa)
MTMR6LOW QUALITY PROTEIN: myotubularin-related protein 6. (629 aa)
MTMR2Myotubularin-related protein 2 isoform X1. (574 aa)
DGKQDiacylglycerol kinase. (845 aa)
LOC102375443Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2-like isoform X1. (1114 aa)
INPP5FPhosphatidylinositide phosphatase SAC2 isoform X1. (1135 aa)
SACM1LPhosphatidylinositide phosphatase SAC1 isoform X3. (484 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (895 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1. (710 aa)
PI4K2BPhosphatidylinositol 4-kinase type 2-beta. (462 aa)
PIK3C2ALOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Belongs to the PI3/PI4-kinase family. (1712 aa)
IPPKInositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (498 aa)
MTMR1Myotubularin-related protein 1 isoform X1. (571 aa)
MTM1Myotubularin isoform X2. (612 aa)
ITPR3LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3. (2748 aa)
DGKKDiacylglycerol kinase. (1156 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2721 aa)
LOC102380057Phosphatidylinositol 3-kinase regulatory subunit gamma. (419 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma. (675 aa)
PRKCBNon-specific serine/threonine protein kinase. (544 aa)
DGKDDiacylglycerol kinase. (1174 aa)
DGKZDiacylglycerol kinase. (1195 aa)
OCRLInositol polyphosphate 5-phosphatase OCRL-1 isoform X1. (836 aa)
PIKFYVE1-phosphatidylinositol 3-phosphate 5-kinase. (2126 aa)
CALML6Calmodulin-like protein 6 isoform X1. (190 aa)
PPIP5K1Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1355 aa)
INPP4BType II inositol 3,4-bisphosphate 4-phosphatase. (1055 aa)
SYNJ1Synaptojanin-1. (1589 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (648 aa)
DGKIDiacylglycerol kinase. (953 aa)
INPP5BType II inositol 1,4,5-trisphosphate 5-phosphatase isoform X3. (921 aa)
LOC102368550Phosphatidate cytidylyltransferase; Belongs to the CDS family. (574 aa)
IPMKKinase; Belongs to the inositol phosphokinase (IPK) family. (366 aa)
PI4K2ALOW QUALITY PROTEIN: phosphatidylinositol 4-kinase type 2-alpha. (391 aa)
LOC102379301Diacylglycerol kinase. (910 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (396 aa)
IMPAD1Inositol monophosphatase 3. (272 aa)
MTMR4Myotubularin-related protein 4 isoform X3. (1171 aa)
Your Current Organism:
Alligator sinensis
NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494
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