STRINGSTRING
CCNA2 CCNA2 VDAC2 VDAC2 GADD45B GADD45B LOC102375355 LOC102375355 CCNE2 CCNE2 MAP2K1 MAP2K1 MAPK12 MAPK12 CCND1 CCND1 PPP1CC PPP1CC RAD9B RAD9B MAP2K2 MAP2K2 E2F1 E2F1 CCNE1 CCNE1 MRE11 MRE11 TGFB2 TGFB2 LOC112547860 LOC112547860 LOC102375115 LOC102375115 CHEK2 CHEK2 HRAS HRAS CCND3 CCND3 FBXW11 FBXW11 SLC25A4 SLC25A4 PIK3CD PIK3CD RBL2 RBL2 PIK3R1 PIK3R1 RAF1 RAF1 VDAC1 VDAC1 GADD45G GADD45G LOC102374630 LOC102374630 MRAS MRAS VDAC3 VDAC3 NFATC2 NFATC2 ZFP36L1 ZFP36L1 MAPK13 MAPK13 RAD50 RAD50 CAPN11 CAPN11 LOC102374877 LOC102374877 MYC MYC MAPKAPK2 MAPKAPK2 SIRT1 SIRT1 CCNB3 CCNB3 MAPK14 MAPK14 E2F5 E2F5 MCU MCU CDK1 CDK1 MAP2K3 MAP2K3 CAPN2 CAPN2 PPID PPID RAD9A RAD9A LOC102378986 LOC102378986 LOC102375088 LOC102375088 TGFBR2 TGFBR2 LOC102367803 LOC102367803 IGFBP3 IGFBP3 PPP1CA PPP1CA LOC102384953 LOC102384953 CALM3 CALM3 PIK3R2 PIK3R2 GATA4 GATA4 LOC102369688 LOC102369688 SMAD3 SMAD3 TSC1 TSC1 RBL1 RBL1 LOC102378561 LOC102378561 AKT2 AKT2 CCNA1 CCNA1 NRAS NRAS E2F2 E2F2 LOC102382365 LOC102382365 CDKN1B CDKN1B NFATC4 NFATC4 LOC102380209 LOC102380209 CDK2 CDK2 LIN37 LIN37 AKT1 AKT1 FOXM1 FOXM1 CALML4 CALML4 TGFB1 TGFB1 LOC102379727 LOC102379727 CAPN1 CAPN1 RBBP4 RBBP4 TRAF3IP2 TRAF3IP2 LOC102386730 LOC102386730 LOC102371879 LOC102371879 NBN NBN MAPK1 MAPK1 FOXO1 FOXO1 SLC25A31 SLC25A31 ATR ATR PIK3CB PIK3CB CALM1 CALM1 PPP3CC PPP3CC CCNB2 CCNB2 CCNB1 CCNB1 PTEN PTEN LOC102385058 LOC102385058 LIN54 LIN54 NFATC1 NFATC1 CDK6 CDK6 CDC25A CDC25A RAD1 RAD1 CDK4 CDK4 HIPK1 HIPK1 LOC102375250 LOC102375250 SMAD2 SMAD2 LOC102384475 LOC102384475 LOC102382206 LOC102382206 LOC102368919 LOC102368919 RELA RELA TP53 TP53 LOC102381867 LOC102381867 LOC102379493 LOC102379493 LOC102387244 LOC102387244 MAP2K6 MAP2K6 LOC102386566 LOC102386566 LOC102368503 LOC102368503 PIK3CA PIK3CA TGFBR1 TGFBR1 NFATC3 NFATC3 CACNA1D CACNA1D RRAS2 RRAS2 HIPK2 HIPK2 RHEB RHEB TRPV4 TRPV4 CHEK1 CHEK1 TGFB3 TGFB3 ETS1 ETS1 PPP3R1 PPP3R1 AKT3 AKT3 RASSF5 RASSF5 MYBL2 MYBL2 PPP3CA PPP3CA CDKN1A CDKN1A E2F3 E2F3 ITPR3 ITPR3 ITPR1 ITPR1 LOC102380057 LOC102380057 TSC2 TSC2 KRAS KRAS MDM2 MDM2 IL6 IL6 SLC25A5 SLC25A5 E2F4 E2F4 MTOR MTOR FOXO3 FOXO3 CALML6 CALML6 RB1 RB1 PPP3CB PPP3CB LOC102369661 LOC102369661 GADD45A GADD45A TRPM7 TRPM7 LOC102387373 LOC102387373 LOC102388710 LOC102388710 LOC102388210 LOC102388210 MAPK11 MAPK11 PPP1CB PPP1CB HIPK3 HIPK3 LOC102379232 LOC102379232 LIN9 LIN9 NFKB1 NFKB1 HUS1 HUS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCNA2cyclin-A2; Belongs to the cyclin family. (297 aa)
VDAC2Voltage-dependent anion-selective channel protein 2 isoform X1. (296 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (123 aa)
LOC102375355Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (96 aa)
CCNE2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (412 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
MAPK12Mitogen-activated protein kinase. (361 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (292 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (411 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (388 aa)
E2F1Transcription factor E2F1. (357 aa)
CCNE1LOW QUALITY PROTEIN: G1/S-specific cyclin-E1; Belongs to the cyclin family. (415 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (715 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
LOC112547860GTPase HRas-like. (186 aa)
LOC102375115Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
CHEK2Serine/threonine-protein kinase Chk2. (441 aa)
HRASGTPase HRas. (189 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (238 aa)
FBXW11F-box/WD repeat-containing protein 11 isoform X1. (531 aa)
SLC25A4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (272 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
RBL2Retinoblastoma-like protein 2 isoform X1. (1008 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (667 aa)
VDAC1Voltage-dependent anion-selective channel protein 1 isoform X1. (283 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (141 aa)
LOC102374630Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
MRASRas-related protein M-Ras isoform X1. (208 aa)
VDAC3Voltage-dependent anion-selective channel protein 3. (296 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (918 aa)
ZFP36L1mRNA decay activator protein ZFP36L1 isoform X1. (335 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
RAD50DNA repair protein RAD50 isoform X1. (1312 aa)
CAPN11Calpain-11; Belongs to the peptidase C2 family. (705 aa)
LOC102374877Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
MYCMyc proto-oncogene protein. (238 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (375 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (557 aa)
CCNB3LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B3; Belongs to the cyclin family. (404 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
E2F5Transcription factor E2F5. (340 aa)
MCUCalcium uniporter protein, mitochondrial. (309 aa)
CDK1LOW QUALITY PROTEIN: cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (311 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3 isoform X1; Belongs to the protein kinase superfamily. (337 aa)
CAPN2Calpain-2 catalytic subunit; Belongs to the peptidase C2 family. (700 aa)
PPIDPeptidyl-prolyl cis-trans isomerase D isoform X1. (370 aa)
RAD9ACell cycle checkpoint control protein RAD9A isoform X3. (542 aa)
LOC102378986Major histocompatibility complex class I-related gene protein-like; Belongs to the MHC class I family. (369 aa)
LOC102375088Major histocompatibility complex class I-related gene protein-like isoform X1; Belongs to the MHC class I family. (421 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (531 aa)
LOC102367803Major histocompatibility complex class I-related gene protein-like; Belongs to the MHC class I family. (380 aa)
IGFBP3Insulin-like growth factor-binding protein 3. (180 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (301 aa)
LOC102384953ADP/ATP translocase 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (290 aa)
CALM3Calmodulin-3; Belongs to the calmodulin family. (144 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (727 aa)
GATA4Transcription factor GATA-4 isoform X1. (410 aa)
LOC102369688Calmodulin-alpha-like; Belongs to the calmodulin family. (149 aa)
SMAD3Mothers against decapentaplegic homolog. (321 aa)
TSC1LOW QUALITY PROTEIN: hamartin. (1162 aa)
RBL1Retinoblastoma-like protein 1 isoform X1. (1084 aa)
LOC102378561Class I histocompatibility antigen, F10 alpha chain-like isoform X1; Belongs to the MHC class I family. (344 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CCNA1cyclin-A1 isoform X1; Belongs to the cyclin family. (455 aa)
NRASGTPase NRas. (97 aa)
E2F2Transcription factor E2F2 isoform X1. (433 aa)
LOC102382365Major histocompatibility complex class I-related gene protein-like; Belongs to the MHC class I family. (188 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (170 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4 isoform X1. (831 aa)
LOC102380209Class I histocompatibility antigen, F10 alpha chain; Belongs to the MHC class I family. (334 aa)
CDK2Cyclin-dependent kinase 2. (297 aa)
LIN37Protein lin-37 homolog. (254 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FOXM1Forkhead box protein M1 isoform X1. (621 aa)
CALML4Calmodulin-like protein 4 isoform X1. (152 aa)
TGFB1Transforming growth factor beta-1. (235 aa)
LOC102379727Inositol 1,4,5-trisphosphate receptor type 2. (1420 aa)
CAPN1Calpain-1 catalytic subunit; Belongs to the peptidase C2 family. (714 aa)
RBBP4Histone-binding protein RBBP4 isoform X1. (431 aa)
TRAF3IP2Adapter protein CIKS isoform X1. (557 aa)
LOC102386730Checkpoint protein; Belongs to the HUS1 family. (337 aa)
LOC102371879TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (565 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (717 aa)
MAPK1Mitogen-activated protein kinase. (422 aa)
FOXO1Forkhead box protein O1. (473 aa)
SLC25A31ADP/ATP translocase 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (313 aa)
ATRSerine/threonine-protein kinase ATR isoform X1; Belongs to the PI3/PI4-kinase family. (2655 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (113 aa)
PPP3CCSerine/threonine-protein phosphatase. (438 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (382 aa)
CCNB1G2/mitotic-specific cyclin-B1 isoform X1; Belongs to the cyclin family. (440 aa)
PTENannotation not available (206 aa)
LOC102385058Major histocompatibility complex class I-related gene protein-like; Belongs to the MHC class I family. (384 aa)
LIN54Protein lin-54 homolog isoform X1. (833 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (636 aa)
CDK6Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily. (337 aa)
CDC25ALOW QUALITY PROTEIN: M-phase inducer phosphatase 1. (521 aa)
RAD1Cell cycle checkpoint protein RAD1 isoform X1. (253 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (295 aa)
HIPK1LOW QUALITY PROTEIN: homeodomain-interacting protein kinase 1. (1216 aa)
LOC102375250Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (564 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
LOC102384475Class I histocompatibility antigen, F10 alpha chain-like; Belongs to the MHC class I family. (352 aa)
LOC102382206Major histocompatibility complex class I-related gene protein-like; Belongs to the MHC class I family. (203 aa)
LOC102368919Major histocompatibility complex class I-related gene protein-like; Belongs to the MHC class I family. (511 aa)
RELATranscription factor p65. (554 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (397 aa)
LOC102381867F-box/WD repeat-containing protein 1A. (517 aa)
LOC102379493H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1; Belongs to the MHC class I family. (357 aa)
LOC102387244DLA class I histocompatibility antigen, A9/A9 alpha chain-like. (216 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (435 aa)
LOC102386566Major histocompatibility complex class I-related gene protein-like; Belongs to the MHC class I family. (389 aa)
LOC102368503Major histocompatibility complex class I-related gene protein-like; Belongs to the MHC class I family. (364 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (440 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3. (1078 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2105 aa)
RRAS2Ras-related protein R-Ras2 isoform X1. (178 aa)
HIPK2Homeodomain-interacting protein kinase 2 isoform X1. (1225 aa)
RHEBGTP-binding protein Rheb isoform X1. (183 aa)
TRPV4LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (865 aa)
CHEK1Serine/threonine-protein kinase Chk1. (470 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (342 aa)
ETS1Protein C-ets-1 isoform X1. (521 aa)
PPP3R1Calcineurin subunit B type 1. (160 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
RASSF5LOW QUALITY PROTEIN: ras association domain-containing protein 5. (328 aa)
MYBL2Myb-related protein B isoform X1. (706 aa)
PPP3CASerine/threonine-protein phosphatase. (544 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (199 aa)
E2F3Transcription factor E2F3. (419 aa)
ITPR3LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3. (2748 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2721 aa)
LOC102380057Phosphatidylinositol 3-kinase regulatory subunit gamma. (419 aa)
TSC2Tuberin isoform X1. (1747 aa)
KRASGTPase KRas. (203 aa)
MDM2E3 ubiquitin-protein ligase Mdm2 isoform X3. (591 aa)
IL6Interleukin-6. (152 aa)
SLC25A5ADP/ATP translocase 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (283 aa)
E2F4Transcription factor E2F4. (395 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2551 aa)
FOXO3Forkhead box protein O3. (488 aa)
CALML6Calmodulin-like protein 6 isoform X1. (190 aa)
RB1Retinoblastoma-associated protein isoform X1. (905 aa)
PPP3CBSerine/threonine-protein phosphatase. (530 aa)
LOC102369661Plasminogen activator inhibitor 1; Belongs to the serpin family. (408 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (119 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7. (1108 aa)
LOC102387373Serine-protein kinase ATM isoform X1; Belongs to the PI3/PI4-kinase family. (1934 aa)
LOC102388710Major histocompatibility complex class I-related gene protein-like; Belongs to the MHC class I family. (303 aa)
LOC102388210Major histocompatibility complex class I-related gene protein-like; Belongs to the MHC class I family. (284 aa)
MAPK11Mitogen-activated protein kinase. (283 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (326 aa)
HIPK3Homeodomain-interacting protein kinase 3 isoform X1. (1228 aa)
LOC102379232Major histocompatibility complex class I-related gene protein-like isoform X1; Belongs to the MHC class I family. (400 aa)
LIN9Protein lin-9 homolog isoform X1. (586 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (1022 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (276 aa)
Your Current Organism:
Alligator sinensis
NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494
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