STRINGSTRING
ADCY2 ADCY2 GNA13 GNA13 CALCA CALCA PLCB2 PLCB2 CALD1 CALD1 BRAF BRAF LOC102374118 LOC102374118 MAP2K1 MAP2K1 PPP1CC PPP1CC RAMP2 RAMP2 MAP2K2 MAP2K2 MRVI1 MRVI1 ADORA2A ADORA2A PRKCG PRKCG PRKCQ PRKCQ ADRA1B ADRA1B PRKCH PRKCH GNA11 GNA11 LOC102367833 LOC102367833 EDNRA EDNRA RAF1 RAF1 AGT AGT CALCRL CALCRL ACTA2 ACTA2 LOC102373710 LOC102373710 PLA2G4A PLA2G4A LOC102372714 LOC102372714 KCNMB4 KCNMB4 LOC102372245 LOC102372245 LOC102375479 LOC102375479 GNA12 GNA12 ACTG2 ACTG2 PRKCD PRKCD LOC102375729 LOC102375729 MYL9 MYL9 LOC102368078 LOC102368078 RAMP1 RAMP1 EDN1 EDN1 LOC102388376 LOC102388376 MYLK2 MYLK2 MYH9 MYH9 LOC102387857 LOC102387857 RAMP3 RAMP3 RHOA RHOA LOC102385462 LOC102385462 PPP1CA PPP1CA MYLK3 MYLK3 ADRA1A ADRA1A CALM3 CALM3 ROCK1 ROCK1 LOC102369688 LOC102369688 ADORA2B ADORA2B LOC102384716 LOC102384716 PLA2G3 PLA2G3 LOC102380947 LOC102380947 ADCY6 ADCY6 GUCY1B1 GUCY1B1 PRKACA PRKACA LOC102383974 LOC102383974 LOC102385707 LOC102385707 LOC102368757 LOC102368757 LOC102370673 LOC102370673 LOC102385959 LOC102385959 CALML4 CALML4 LOC102379727 LOC102379727 LOC102383248 LOC102383248 GUCY1A1 GUCY1A1 GUCY1A2 GUCY1A2 PLA2G1B PLA2G1B MAPK1 MAPK1 AVPR1B AVPR1B PLA2G12A PLA2G12A CALM1 CALM1 LOC102381567 LOC102381567 PLCB4 PLCB4 MYLK MYLK LOC102386454 LOC102386454 LOC102386211 LOC102386211 PLA2G12B PLA2G12B AGTR1 AGTR1 LOC102387635 LOC102387635 LOC102377714 LOC102377714 LOC112548143 LOC112548143 LOC102377522 LOC102377522 ADCY9 ADCY9 LOC102375250 LOC102375250 MYH10 MYH10 PLA2G4C PLA2G4C ADCY4 ADCY4 CACNA1S CACNA1S ARHGEF1 ARHGEF1 PLCB3 PLCB3 NPR2 NPR2 PRKCA PRKCA LOC112549186 LOC112549186 KCNMB2 KCNMB2 PPP1R12C PPP1R12C CACNA1D CACNA1D CACNA1C CACNA1C LOC102375853 LOC102375853 LOC102368598 LOC102368598 LOC112549837 LOC112549837 PPP1R12A PPP1R12A ARHGEF12 ARHGEF12 ROCK2 ROCK2 PRKG1 PRKG1 PLCB1 PLCB1 PLA2G10 PLA2G10 GNAS GNAS PRKCE PRKCE LOC102387013 LOC102387013 LOC102369559 LOC102369559 ADCY8 ADCY8 MYLK4 MYLK4 ITPR3 ITPR3 MYH11 MYH11 ITPR1 ITPR1 PRKCB PRKCB LOC102371226 LOC102371226 ADCY1 ADCY1 LOC102375383 LOC102375383 CALML6 CALML6 PPP1R12B PPP1R12B ADCY3 ADCY3 PRKACB PRKACB CACNA1F CACNA1F KCNMA1 KCNMA1 ADCY7 ADCY7 ARHGEF11 ARHGEF11 PPP1CB PPP1CB LOC102385224 LOC102385224 EDN2 EDN2 LOC102384971 LOC102384971 ADRA1D ADRA1D
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY2LOW QUALITY PROTEIN: adenylate cyclase type 2. (921 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13. (310 aa)
CALCACalcitonin. (138 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1207 aa)
CALD1Caldesmon isoform X1. (840 aa)
BRAFSerine/threonine-protein kinase B-raf. (735 aa)
LOC102374118Natriuretic peptides A-like. (140 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
RAMP2Receptor activity-modifying protein 2. (169 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (388 aa)
MRVI1Protein MRVI1 isoform X3. (1622 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (436 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (689 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (708 aa)
ADRA1Balpha-1B adrenergic receptor. (511 aa)
PRKCHProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11 isoform X1. (357 aa)
LOC102367833Natriuretic peptides A. (166 aa)
EDNRAEndothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (417 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (667 aa)
AGTAngiotensinogen; Belongs to the serpin family. (457 aa)
CALCRLCalcitonin gene-related peptide type 1 receptor; Belongs to the G-protein coupled receptor 2 family. (467 aa)
ACTA2Actin, aortic smooth muscle. (377 aa)
LOC102373710Phospholipase A(2). (148 aa)
PLA2G4APhospholipase A2. (749 aa)
LOC102372714Vasotocin-neurophysin VT-like; Belongs to the vasopressin/oxytocin family. (179 aa)
KCNMB4Calcium-activated potassium channel subunit beta-4 isoform X1. (211 aa)
LOC102372245Phospholipase A(2). (135 aa)
LOC102375479Phospholipase A(2). (166 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12. (305 aa)
ACTG2Actin, gamma-enteric smooth muscle. (376 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (685 aa)
LOC102375729Phospholipase A(2). (137 aa)
MYL9Myosin regulatory light polypeptide 9. (172 aa)
LOC102368078Myosin light polypeptide 6 isoform X1. (152 aa)
RAMP1Receptor activity-modifying protein 1 isoform X1. (144 aa)
EDN1Endothelin-1. (200 aa)
LOC102388376Guanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (333 aa)
MYLK2Myosin light chain kinase 2, skeletal/cardiac muscle. (610 aa)
MYH9Myosin-9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa)
LOC102387857Myosin light chain kinase, smooth muscle-like isoform X1; Belongs to the protein kinase superfamily. (468 aa)
RAMP3Receptor activity-modifying protein 3 isoform X1. (156 aa)
RHOATransforming protein RhoA. (193 aa)
LOC102385462Phospholipase A2. (839 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (301 aa)
MYLK3Myosin light chain kinase 3 isoform X1. (878 aa)
ADRA1Aalpha-1A adrenergic receptor. (296 aa)
CALM3Calmodulin-3; Belongs to the calmodulin family. (144 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1377 aa)
LOC102369688Calmodulin-alpha-like; Belongs to the calmodulin family. (149 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (335 aa)
LOC102384716Phospholipase A2. (851 aa)
PLA2G3Group 3 secretory phospholipase A2 isoform X1. (650 aa)
LOC102380947Putative calcium-activated potassium channel subunit beta. (207 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1242 aa)
GUCY1B1Guanylate cyclase soluble subunit beta-1 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (692 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (401 aa)
LOC102383974Phospholipase A2. (824 aa)
LOC102385707Phospholipase A2. (816 aa)
LOC102368757Adenosine receptor A1-like. (354 aa)
LOC102370673Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (626 aa)
LOC102385959Phospholipase A2. (860 aa)
CALML4Calmodulin-like protein 4 isoform X1. (152 aa)
LOC102379727Inositol 1,4,5-trisphosphate receptor type 2. (1420 aa)
LOC102383248Transforming protein RhoA-like. (315 aa)
GUCY1A1Guanylate cyclase soluble subunit alpha-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
GUCY1A2Guanylate cyclase soluble subunit alpha-2 isoform X2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
PLA2G1BPhospholipase A(2). (166 aa)
MAPK1Mitogen-activated protein kinase. (422 aa)
AVPR1BVasopressin V1b receptor; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (327 aa)
PLA2G12AGroup XIIA secretory phospholipase A2. (157 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (113 aa)
LOC102381567alpha-1A adrenergic receptor-like. (235 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MYLKMyosin light chain kinase, smooth muscle isoform X2. (1912 aa)
LOC102386454Phospholipase A2. (863 aa)
LOC102386211Phospholipase A2. (838 aa)
PLA2G12BGroup XIIB secretory phospholipase A2-like protein isoform X1. (202 aa)
AGTR1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
LOC102387635Adenylate cyclase type 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (819 aa)
LOC102377714Phospholipase A2. (815 aa)
LOC112548143Cytosolic phospholipase A2 gamma-like. (293 aa)
LOC102377522Myosin light chain 1/3, skeletal muscle isoform. (91 aa)
ADCY9Adenylate cyclase type 9 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (625 aa)
LOC102375250Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (564 aa)
MYH10Myosin-10 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1726 aa)
PLA2G4CCytosolic phospholipase A2 gamma. (499 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1094 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1898 aa)
ARHGEF1LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 1. (997 aa)
PLCB3Phosphoinositide phospholipase C. (795 aa)
NPR2Guanylate cyclase. (539 aa)
PRKCANon-specific serine/threonine protein kinase. (552 aa)
LOC112549186ADM-like. (157 aa)
KCNMB2Calcium-activated potassium channel subunit beta-2 isoform X1. (314 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (778 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2105 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2175 aa)
LOC102375853Guanylate cyclase soluble subunit beta-2-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
LOC102368598Phospholipase A(2). (226 aa)
LOC112549837Receptor activity-modifying protein 1-like. (175 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (969 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12 isoform X1. (1461 aa)
ROCK2Rho-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1455 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
PLA2G10Phospholipase A(2). (182 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoform X1. (386 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (742 aa)
LOC102387013Phospholipase A2. (704 aa)
LOC102369559Guanylate cyclase. (859 aa)
ADCY8Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (943 aa)
MYLK4Myosin light chain kinase family member 4 isoform X1. (666 aa)
ITPR3LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3. (2748 aa)
MYH11Myosin-11 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1981 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2721 aa)
PRKCBNon-specific serine/threonine protein kinase. (544 aa)
LOC102371226LOW QUALITY PROTEIN: myosin-10-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2118 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1114 aa)
LOC102375383LOW QUALITY PROTEIN: potassium channel subfamily U member 1. (975 aa)
CALML6Calmodulin-like protein 6 isoform X1. (190 aa)
PPP1R12BProtein phosphatase 1 regulatory subunit. (955 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1130 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (401 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1915 aa)
KCNMA1LOW QUALITY PROTEIN: calcium-activated potassium channel subunit alpha-1. (1094 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1074 aa)
ARHGEF11LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 11. (1699 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (326 aa)
LOC102385224Phospholipase A2. (811 aa)
EDN2Endothelin-2. (194 aa)
LOC102384971Phospholipase A2. (844 aa)
ADRA1Dalpha-1D adrenergic receptor. (507 aa)
Your Current Organism:
Alligator sinensis
NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494
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