STRINGSTRING
MAPK8 MAPK8 MALT1 MALT1 MAPK12 MAPK12 EGR2 EGR2 IRF1 IRF1 PTGS2 PTGS2 LOC112547860 LOC112547860 NFKBIA NFKBIA HRAS HRAS KSR1 KSR1 PAK1 PAK1 LOC102377557 LOC102377557 PIK3CD PIK3CD PIK3R1 PIK3R1 RAF1 RAF1 MRAS MRAS NFATC2 NFATC2 MAPK13 MAPK13 CYLD CYLD MAPKAPK2 MAPKAPK2 MAPK14 MAPK14 PLCG2 PLCG2 IKBKB IKBKB LOC102383063 LOC102383063 LOC102369160 LOC102369160 CBLB CBLB IKBKG IKBKG PRKCD PRKCD IL10 IL10 MAP3K14 MAP3K14 RHOA RHOA CALM3 CALM3 FCER1G FCER1G PIK3R2 PIK3R2 LOC102369688 LOC102369688 AKT2 AKT2 NRAS NRAS LOC102384158 LOC102384158 NFATC4 NFATC4 LSP1 LSP1 LOC102373125 LOC102373125 AKT1 AKT1 CALML4 CALML4 LOC102379727 LOC102379727 LOC102383248 LOC102383248 MAPK1 MAPK1 CHUK CHUK IKBKE IKBKE JUN JUN PIK3CB PIK3CB CALM1 CALM1 PPP3CC PPP3CC NFKB2 NFKB2 RELB RELB STAT1 STAT1 LOC102378738 LOC102378738 LOC102375638 LOC102375638 NFATC1 NFATC1 IL12A IL12A LOC102383516 LOC102383516 IL23A IL23A LOC102369595 LOC102369595 LOC112547978 LOC112547978 SRC SRC IRF9 IRF9 STAT2 STAT2 LOC112548293 LOC112548293 LOC102379567 LOC102379567 LOC102375250 LOC102375250 LOC102381365 LOC102381365 LOC102372525 LOC102372525 RELA RELA CARD9 CARD9 LOC102383014 LOC102383014 LOC102369359 LOC102369359 LOC102380544 LOC102380544 LOC112548845 LOC112548845 LOC102372275 LOC102372275 LOC102383266 LOC102383266 PIK3CA PIK3CA LOC102374542 LOC102374542 LOC102386995 LOC102386995 NFATC3 NFATC3 RRAS2 RRAS2 PTPN11 PTPN11 LOC102374052 LOC102374052 ARHGEF12 ARHGEF12 IL12B IL12B PPP3R1 PPP3R1 AKT3 AKT3 LOC102384848 LOC102384848 LOC102385102 LOC102385102 PPP3CA PPP3CA LOC102382314 LOC102382314 ITPR3 ITPR3 ITPR1 ITPR1 LOC102380057 LOC102380057 PLK3 PLK3 KRAS KRAS MAPK9 MAPK9 MDM2 MDM2 IL6 IL6 LOC112551296 LOC112551296 LOC106722539 LOC106722539 CALML6 CALML6 LOC102384537 LOC102384537 LOC102385046 LOC102385046 LOC106722538 LOC106722538 LOC112551377 LOC112551377 PPP3CB PPP3CB LOC112551376 LOC112551376 CCL17 CCL17 SYK SYK LOC112551297 LOC112551297 LOC106722537 LOC106722537 LOC106722716 LOC106722716 BCL10 BCL10 MAPK11 MAPK11 LOC102372690 LOC102372690 NFKB1 NFKB1 LOC102373345 LOC102373345
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK8Mitogen-activated protein kinase. (427 aa)
MALT1Mucosa-associated lymphoid tissue lymphoma translocation protein 1. (770 aa)
MAPK12Mitogen-activated protein kinase. (361 aa)
EGR2E3 SUMO-protein ligase EGR2. (357 aa)
IRF1Interferon regulatory factor. (318 aa)
PTGS2Prostaglandin G/H synthase 2. (605 aa)
LOC112547860GTPase HRas-like. (186 aa)
NFKBIANF-kappa-B inhibitor alpha. (316 aa)
HRASGTPase HRas. (189 aa)
KSR1Kinase suppressor of Ras 1 isoform X2. (829 aa)
PAK1Non-specific serine/threonine protein kinase. (546 aa)
LOC102377557interleukin-17D-like isoform X1. (232 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (667 aa)
MRASRas-related protein M-Ras isoform X1. (208 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (918 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
CYLDUbiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family. (954 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (375 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (757 aa)
LOC102383063C-type lectin domain family 4 member E-like. (220 aa)
LOC102369160Ubiquitin carboxyl-terminal hydrolase CYLD-like; Belongs to the peptidase C19 family. (788 aa)
CBLBE3 ubiquitin-protein ligase CBL-B isoform X1. (976 aa)
IKBKGNF-kappa-B essential modulator. (534 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (685 aa)
IL10Interleukin-10. (177 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (938 aa)
RHOATransforming protein RhoA. (193 aa)
CALM3Calmodulin-3; Belongs to the calmodulin family. (144 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (91 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (727 aa)
LOC102369688Calmodulin-alpha-like; Belongs to the calmodulin family. (149 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
NRASGTPase NRas. (97 aa)
LOC102384158Ubiquitin carboxyl-terminal hydrolase CYLD-like; Belongs to the peptidase C19 family. (846 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4 isoform X1. (831 aa)
LSP1Lymphocyte-specific protein 1 isoform X1. (378 aa)
LOC102373125Apoptosis-associated speck-like protein containing a CARD. (192 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CALML4Calmodulin-like protein 4 isoform X1. (152 aa)
LOC102379727Inositol 1,4,5-trisphosphate receptor type 2. (1420 aa)
LOC102383248Transforming protein RhoA-like. (315 aa)
MAPK1Mitogen-activated protein kinase. (422 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (735 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (752 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (282 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (113 aa)
PPP3CCSerine/threonine-protein phosphatase. (438 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit. (903 aa)
RELBTranscription factor RelB. (614 aa)
STAT1Signal transducer and activator of transcription. (753 aa)
LOC102378738Tumor necrosis factor. (231 aa)
LOC102375638C-type lectin domain family 4 member D-like. (215 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (636 aa)
IL12AInterleukin-12 subunit alpha; Belongs to the IL-6 superfamily. (145 aa)
LOC102383516LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 3-like. (473 aa)
IL23AInterleukin-23 subunit alpha. (126 aa)
LOC102369595Interleukin-1; Belongs to the IL-1 family. (279 aa)
LOC112547978Interleukin-1. (241 aa)
SRCTyrosine-protein kinase. (561 aa)
IRF9Interferon regulatory factor 9. (451 aa)
STAT2LOW QUALITY PROTEIN: signal transducer and activator of transcription 2. (785 aa)
LOC112548293C-type lectin domain family 7 member A-like. (268 aa)
LOC102379567C-type lectin domain family 7 member A-like. (290 aa)
LOC102375250Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (564 aa)
LOC102381365LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 3-like. (963 aa)
LOC102372525NACHT, LRR and PYD domains-containing protein 12-like. (890 aa)
RELATranscription factor p65. (554 aa)
CARD9Caspase recruitment domain-containing protein 9. (512 aa)
LOC102383014LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 3-like. (1049 aa)
LOC102369359C-type lectin domain family 7 member A-like isoform X1. (183 aa)
LOC102380544NACHT, LRR and PYD domains-containing protein 3-like. (555 aa)
LOC112548845C-type lectin domain family 7 member A-like. (288 aa)
LOC102372275LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 3-like. (613 aa)
LOC102383266NACHT, LRR and PYD domains-containing protein 3-like. (960 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC102374542Mitogen-activated protein kinase. (464 aa)
LOC102386995Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (603 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3. (1078 aa)
RRAS2Ras-related protein R-Ras2 isoform X1. (178 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (609 aa)
LOC102374052Mucosa-associated lymphoid tissue lymphoma translocation protein 1-like isoform X1. (647 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12 isoform X1. (1461 aa)
IL12BInterleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (320 aa)
PPP3R1Calcineurin subunit B type 1. (160 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
LOC102384848Caspase-8-like; Belongs to the peptidase C14A family. (556 aa)
LOC102385102Caspase-8-like; Belongs to the peptidase C14A family. (479 aa)
PPP3CASerine/threonine-protein phosphatase. (544 aa)
LOC102382314Mucosa-associated lymphoid tissue lymphoma translocation protein 1-like. (785 aa)
ITPR3LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3. (2748 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2721 aa)
LOC102380057Phosphatidylinositol 3-kinase regulatory subunit gamma. (419 aa)
PLK3Serine/threonine-protein kinase PLK. (642 aa)
KRASGTPase KRas. (203 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MDM2E3 ubiquitin-protein ligase Mdm2 isoform X3. (591 aa)
IL6Interleukin-6. (152 aa)
LOC112551296C-type lectin domain family 6 member A-like isoform X1. (223 aa)
LOC106722539Natural killer cells antigen CD94-like isoform X1. (259 aa)
CALML6Calmodulin-like protein 6 isoform X1. (190 aa)
LOC102384537C-type lectin domain family 7 member A-like. (423 aa)
LOC102385046C-type lectin domain family 4 member D-like isoform X1. (207 aa)
LOC106722538Natural killer cells antigen CD94-like. (241 aa)
LOC112551377C-type lectin domain family 7 member A-like. (265 aa)
PPP3CBSerine/threonine-protein phosphatase. (530 aa)
LOC112551376C-type lectin domain family 7 member A-like. (292 aa)
CCL17C-C motif chemokine. (214 aa)
SYKTyrosine-protein kinase SYK isoform X1. (658 aa)
LOC112551297C-type lectin domain family 4 member E-like isoform X1. (257 aa)
LOC106722537Natural killer cells antigen CD94-like. (245 aa)
LOC106722716LOW QUALITY PROTEIN: C-type lectin domain family 6 member A-like. (190 aa)
BCL10B-cell lymphoma/leukemia 10 isoform X1. (226 aa)
MAPK11Mitogen-activated protein kinase. (283 aa)
LOC102372690NACHT, LRR and PYD domains-containing protein 3-like isoform X1. (1116 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (1022 aa)
LOC102373345Caspase-1-like isoform X1; Belongs to the peptidase C14A family. (414 aa)
Your Current Organism:
Alligator sinensis
NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494
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