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FSHB FSHB MAPK8 MAPK8 ADCY2 ADCY2 PLCB2 PLCB2 MAP2K1 MAP2K1 MAPK12 MAPK12 MAP2K2 MAP2K2 MMP2 MMP2 LOC112547860 LOC112547860 HRAS HRAS LOC102371171 LOC102371171 GNRH2 GNRH2 LOC102368863 LOC102368863 GNA11 GNA11 RAF1 RAF1 MAP3K3 MAP3K3 CDC42 CDC42 GRB2 GRB2 MAPK13 MAPK13 PLA2G4A PLA2G4A MAPK14 MAPK14 CAMK2A CAMK2A MAP2K3 MAP2K3 CGA CGA PRKCD PRKCD ATF4 ATF4 LOC102388376 LOC102388376 LOC102385462 LOC102385462 CALM3 CALM3 LOC102369688 LOC102369688 LOC102384716 LOC102384716 NRAS NRAS ADCY6 ADCY6 PRKACA PRKACA MMP14 MMP14 LOC102383974 LOC102383974 LOC102385707 LOC102385707 LOC102370673 LOC102370673 LOC102368467 LOC102368467 LOC102385959 LOC102385959 CALML4 CALML4 LOC102379727 LOC102379727 MAPK1 MAPK1 JUN JUN CALM1 CALM1 PLCB4 PLCB4 LOC102386454 LOC102386454 LOC102386211 LOC102386211 ELK1 ELK1 PTK2B PTK2B LOC102387635 LOC102387635 LOC102377714 LOC102377714 LOC112548143 LOC112548143 SRC SRC MAP2K7 MAP2K7 ADCY9 ADCY9 CAMK2B CAMK2B LOC102375250 LOC102375250 PLA2G4C PLA2G4C ADCY4 ADCY4 CACNA1S CACNA1S PLCB3 PLCB3 MAPK7 MAPK7 MAP2K4 MAP2K4 PRKCA PRKCA MAP2K6 MAP2K6 LOC102374542 LOC102374542 CACNA1D CACNA1D CACNA1C CACNA1C LOC102378203 LOC102378203 MAP3K1 MAP3K1 PLD1 PLD1 MAP3K4 MAP3K4 EGFR EGFR PLCB1 PLCB1 SOS2 SOS2 GNAS GNAS LOC102387013 LOC102387013 SOS1 SOS1 ADCY8 ADCY8 ITPR3 ITPR3 HBEGF HBEGF ITPR1 ITPR1 KRAS KRAS PRKCB PRKCB ADCY1 ADCY1 MAPK9 MAPK9 LOC102381161 LOC102381161 GNRH1 GNRH1 CALML6 CALML6 ADCY3 ADCY3 CAMK2G CAMK2G PRKACB PRKACB CAMK2D CAMK2D LOC102369667 LOC102369667 CACNA1F CACNA1F ADCY7 ADCY7 MAPK11 MAPK11 LOC102385224 LOC102385224 LOC102384971 LOC102384971
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FSHBFollitropin subunit beta. (131 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ADCY2LOW QUALITY PROTEIN: adenylate cyclase type 2. (921 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1207 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
MAPK12Mitogen-activated protein kinase. (361 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (388 aa)
MMP272 kDa type IV collagenase. (662 aa)
LOC112547860GTPase HRas-like. (186 aa)
HRASGTPase HRas. (189 aa)
LOC102371171Lutropin subunit beta-like. (139 aa)
GNRH2Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (86 aa)
LOC102368863Mitogen-activated protein kinase kinase kinase 3-like isoform X1. (621 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11 isoform X1. (357 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (667 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3 isoform X1. (647 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
PLA2G4APhospholipase A2. (749 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (489 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3 isoform X1; Belongs to the protein kinase superfamily. (337 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (685 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X1. (352 aa)
LOC102388376Guanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (333 aa)
LOC102385462Phospholipase A2. (839 aa)
CALM3Calmodulin-3; Belongs to the calmodulin family. (144 aa)
LOC102369688Calmodulin-alpha-like; Belongs to the calmodulin family. (149 aa)
LOC102384716Phospholipase A2. (851 aa)
NRASGTPase NRas. (97 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1242 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (401 aa)
MMP14Matrix metalloproteinase-14. (570 aa)
LOC102383974Phospholipase A2. (824 aa)
LOC102385707Phospholipase A2. (816 aa)
LOC102370673Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (626 aa)
LOC102368467Gonadotropin-releasing hormone II receptor-like. (474 aa)
LOC102385959Phospholipase A2. (860 aa)
CALML4Calmodulin-like protein 4 isoform X1. (152 aa)
LOC102379727Inositol 1,4,5-trisphosphate receptor type 2. (1420 aa)
MAPK1Mitogen-activated protein kinase. (422 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (282 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (113 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
LOC102386454Phospholipase A2. (863 aa)
LOC102386211Phospholipase A2. (838 aa)
ELK1ETS domain-containing protein Elk-1 isoform X1. (396 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1017 aa)
LOC102387635Adenylate cyclase type 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (819 aa)
LOC102377714Phospholipase A2. (815 aa)
LOC112548143Cytosolic phospholipase A2 gamma-like. (293 aa)
SRCTyrosine-protein kinase. (561 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (349 aa)
ADCY9Adenylate cyclase type 9 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (625 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (719 aa)
LOC102375250Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (564 aa)
PLA2G4CCytosolic phospholipase A2 gamma. (499 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1094 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1898 aa)
PLCB3Phosphoinositide phospholipase C. (795 aa)
MAPK7Mitogen-activated protein kinase. (885 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (422 aa)
PRKCANon-specific serine/threonine protein kinase. (552 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (435 aa)
LOC102374542Mitogen-activated protein kinase. (464 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2105 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2175 aa)
LOC102378203Gonadotropin-releasing hormone II receptor-like; Belongs to the G-protein coupled receptor 1 family. (383 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1 isoform X1. (1343 aa)
PLD1Phospholipase. (1108 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4 isoform X1. (1576 aa)
EGFRReceptor protein-tyrosine kinase. (1164 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
SOS2LOW QUALITY PROTEIN: son of sevenless homolog 2. (1285 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoform X1. (386 aa)
LOC102387013Phospholipase A2. (704 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1288 aa)
ADCY8Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (943 aa)
ITPR3LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3. (2748 aa)
HBEGFProheparin-binding EGF-like growth factor. (200 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2721 aa)
KRASGTPase KRas. (203 aa)
PRKCBNon-specific serine/threonine protein kinase. (544 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1114 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
LOC102381161Serine/threonine-protein kinase ste20-like isoform X1. (643 aa)
GNRH1Progonadoliberin-1 isoform X1. (121 aa)
CALML6Calmodulin-like protein 6 isoform X1. (190 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1130 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1. (626 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (401 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X1. (540 aa)
LOC102369667Putative gonadotropin-releasing hormone II receptor. (382 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1915 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1074 aa)
MAPK11Mitogen-activated protein kinase. (283 aa)
LOC102385224Phospholipase A2. (811 aa)
LOC102384971Phospholipase A2. (844 aa)
Your Current Organism:
Alligator sinensis
NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494
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