97 items (Alligator sinensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ADCY2	LOW QUALITY PROTEIN: adenylate cyclase type 2. (921 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1207 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
	MAP2K2	Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (388 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	LOC112547860	GTPase HRas-like. (186 aa)
	DCT	L-dopachrome tautomerase isoform X1. (557 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (689 aa)
	HRAS	GTPase HRas. (189 aa)
	TYRP1	5,6-dihydroxyindole-2-carboxylic acid oxidase. (536 aa)
	GNAI1	Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
	RAF1	RAF proto-oncogene serine/threonine-protein kinase isoform X1. (667 aa)
	WNT5B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (260 aa)
	CAMK2A	Calcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (489 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	TYR	Tyrosinase. (528 aa)
	EDN1	Endothelin-1. (200 aa)
	LOC102388376	Guanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (333 aa)
	KITLG	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (278 aa)
	CTNNB1	Catenin beta-1. (784 aa)
	CALM3	Calmodulin-3; Belongs to the calmodulin family. (144 aa)
	MC1R	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (318 aa)
	FZD3	LOW QUALITY PROTEIN: frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (670 aa)
	LOC102369688	Calmodulin-alpha-like; Belongs to the calmodulin family. (149 aa)
	LOC102367890	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
	CREB1	Cyclic AMP-responsive element-binding protein 1. (327 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (341 aa)
	NRAS	GTPase NRas. (97 aa)
	LOC102380960	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
	ADCY6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1242 aa)
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (401 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (435 aa)
	LOC102370673	Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (626 aa)
	FZD2	LOW QUALITY PROTEIN: frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (635 aa)
	CALML4	Calmodulin-like protein 4 isoform X1. (152 aa)
	POMC	Pro-opiomelanocortin. (261 aa)
	FZD7	LOW QUALITY PROTEIN: frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (323 aa)
	MAPK1	Mitogen-activated protein kinase. (422 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
	CREB3L3	Cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1. (468 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
	EP300	Histone acetyltransferase p300 isoform X1. (2149 aa)
	CALM1	Calmodulin-1; Belongs to the calmodulin family. (113 aa)
	FZD5	LOW QUALITY PROTEIN: frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (510 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
	CREB3L4	Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (418 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (299 aa)
	CREB3L1	Cyclic AMP-responsive element-binding protein 3-like protein 1. (463 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (269 aa)
	CREBBP	CREB-binding protein. (2468 aa)
	GNAI3	Guanine nucleotide-binding protein G(K) subunit alpha. (302 aa)
	LOC102387635	Adenylate cyclase type 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (819 aa)
	FZD10	Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (494 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (257 aa)
	GSK3B	Glycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (409 aa)
	ADCY9	Adenylate cyclase type 9 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (625 aa)
	CAMK2B	Calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (719 aa)
	DVL2	Segment polarity protein dishevelled homolog DVL-2. (614 aa)
	LOC102375250	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (564 aa)
	ADCY4	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1094 aa)
	PLCB3	Phosphoinositide phospholipase C. (795 aa)
	WNT10A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (413 aa)
	PRKCA	Non-specific serine/threonine protein kinase. (552 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	DVL3	Segment polarity protein dishevelled homolog DVL-3 isoform X1. (711 aa)
	TCF7	Transcription factor 7 isoform X1. (482 aa)
	MITF	Microphthalmia-associated transcription factor isoform X2. (509 aa)
	DVL1	Segment polarity protein dishevelled homolog DVL-1 isoform X1. (663 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (377 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
	GNAI2	Guanine nucleotide-binding protein G(I) subunit alpha-2. (342 aa)
	GNAS	Guanine nucleotide-binding protein G(S) subunit alpha isoform X1. (386 aa)
	ADCY8	Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (943 aa)
	WNT8A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	KRAS	GTPase KRas. (203 aa)
	PRKCB	Non-specific serine/threonine protein kinase. (544 aa)
	ADCY1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1114 aa)
	FZD6	Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (667 aa)
	FZD1	LOW QUALITY PROTEIN: frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (405 aa)
	ASIP	Agouti-signaling protein isoform X1. (127 aa)
	FZD9	LOW QUALITY PROTEIN: frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (538 aa)
	WNT9A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	CALML6	Calmodulin-like protein 6 isoform X1. (190 aa)
	ADCY3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1130 aa)
	CAMK2G	Calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1. (626 aa)
	PRKACB	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (401 aa)
	LEF1	Lymphoid enhancer-binding factor 1. (349 aa)
	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1. (540 aa)
	TCF7L1	Transcription factor 7-like 1. (454 aa)
	CREB3L2	Cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1. (534 aa)
	ADCY7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1074 aa)
	LOC102382089	Endothelin receptor type B-like; Belongs to the G-protein coupled receptor 1 family. (437 aa)
	FZD4	Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (450 aa)
	WNT8B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
	LOC102383312	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)

Your Current Organism:

Alligator sinensis

NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	A0A3Q0GZK6	A0A1U7R1J7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	LOW QUALITY PROTEIN: adenylate cyclase type 2.	0.427
ADCY1	ADCY3	A0A3Q0GZK6	A0A3Q0H7T2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.947
ADCY1	ADCY4	A0A3Q0GZK6	A0A3Q0FR83	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.414
ADCY1	ADCY6	A0A3Q0GZK6	A0A1U7SHY1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.420
ADCY1	ADCY7	A0A3Q0GZK6	A0A3Q0HFT9	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.431
ADCY1	ADCY8	A0A3Q0GZK6	A0A3Q0GSN8	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.956
ADCY1	ADCY9	A0A3Q0GZK6	A0A3Q0FMT3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 9 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.575
ADCY1	CALM1	A0A3Q0GZK6	A0A1U8D8M9	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-1; Belongs to the calmodulin family.	0.936
ADCY1	CALM3	A0A3Q0GZK6	A0A1U7SBC7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-3; Belongs to the calmodulin family.	0.934
ADCY1	CALML4	A0A3Q0GZK6	A0A1U7SRX3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-like protein 4 isoform X1.	0.932
ADCY1	CALML6	A0A3Q0GZK6	A0A3Q0H5T1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-like protein 6 isoform X1.	0.937
ADCY1	GNAI1	A0A3Q0GZK6	A0A1U7RNT4	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I) subunit alpha-1.	0.801
ADCY1	GNAI2	A0A3Q0GZK6	A0A3Q0GK88	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I) subunit alpha-2.	0.801
ADCY1	GNAI3	A0A3Q0GZK6	A0A1U8DJN2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(K) subunit alpha.	0.801
ADCY1	GNAS	A0A3Q0GZK6	A0A3Q0GL81	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(S) subunit alpha isoform X1.	0.961
ADCY1	LOC102369688	A0A3Q0GZK6	A0A1U7SCT2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-alpha-like; Belongs to the calmodulin family.	0.936
ADCY1	LOC102370673	A0A3Q0GZK6	A0A1U7SM61	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.575
ADCY1	LOC102387635	A0A3Q0GZK6	A0A1U8DU60	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.416
ADCY1	PRKACA	A0A3Q0GZK6	A0A1U7SIV0	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily.	0.963
ADCY1	PRKACB	A0A3Q0GZK6	A0A3Q0HA50	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily.	0.963