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| | argS | arginyl-tRNA synthetase. (527 aa) |
| | glyQ | glycyl-tRNA synthetase, alpha subunit. (290 aa) |
| | NIS_1518 | Histidinol-phosphatase, PHP family; Belongs to the PHP hydrolase family. HisK subfamily. (272 aa) |
| | glnA | Glutamine synthase. (481 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (850 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (273 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (304 aa) |
| | hisI | Histidine biosynthesis bifunctional protein HisI; Bifunctional enzyme, phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. (224 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (446 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (254 aa) |
| | NIS_1553 | Homoserine dehydrogenase. (420 aa) |
| | NIS_1602 | Pyruvate:ferredoxin oxidoreductase, beta subunit; Pyruvate synthase component. (332 aa) |
| | NIS_1603 | Pyruvate:ferredoxin oxidoreductase, alpha subunit; Pyruvate synthase component. (405 aa) |
| | NIS_1604 | Pyruvate:ferredoxin oxidoreductase, delta subunit; Pyruvate synthase component. (143 aa) |
| | NIS_1605 | Pyruvate:ferredoxin oxidoreductase, gamma subunit; Pyruvate synthase component. (185 aa) |
| | carA | Carbamoylphosphate synthase, small subunit; Belongs to the CarA family. (379 aa) |
| | NIS_1626 | Conserved hypothetical protein. (282 aa) |
| | NIS_1634 | Conserved hypothetical protein; Similar to C terminus of NAD-glutamate dehydrogenase. (1006 aa) |
| | NIS_1640 | Malate oxidoreductase. (417 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (462 aa) |
| | dapD | Tetrahydrodipicolinate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (393 aa) |
| | accC | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa) |
| | accB | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (151 aa) |
| | NIS_1648 | Conserved hypothetical protein. (571 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (279 aa) |
| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (421 aa) |
| | ispC | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (354 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (421 aa) |
| | NIS_1773 | Pyruvate kinase; Belongs to the pyruvate kinase family. (458 aa) |
| | NIS_1787 | Nitrous oxidase accessory protein NosD. (432 aa) |
| | NIS_1792 | Heme d1 biosynthesis protein NirJ; Nitrite reductase (NO-forming). (367 aa) |
| | NIS_1820 | Uncharacterized protein; Probable gene remnant. Similar to the N-terminal region of Rhodovulum sulfidophilum SH1 dimethylsulfide dehydrogenase alpha subunit precursor DdhA (910 aa). (375 aa) |
| | NIS_1852 | HAD-superfamily hydrolase. (207 aa) |
| | NIS_1453 | Asparaginase. (160 aa) |
| | NIS_1460 | Fumarylacetoacetate hydrolase family protein. (185 aa) |
| | folC | Bifunctional enzyme, dihydrofolate synthase/folylpolyglutamate synthase. (376 aa) |
| | leuS | leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (815 aa) |
| | cysK | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (293 aa) |
| | NIS_1436 | Ferredoxin--nitrite reductase; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (632 aa) |
| | hisH | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (204 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. (238 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (514 aa) |
| | NIS_1406 | Conserved hypothetical protein. (308 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (414 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (330 aa) |
| | kdsA | 3-deoxy-8-phosphooctulonate synthase; Belongs to the KdsA family. (266 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (244 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (516 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (335 aa) |
| | NIS_1309 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (303 aa) |
| | NIS_1308 | Phosphoserine phosphatase. (207 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (918 aa) |
| | NIS_1279 | O-acetylhomoserine sulfhydrylase. (402 aa) |
| | NIS_1278 | O-acetylhomoserine sulfhydrylase. (419 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (369 aa) |
| | NIS_1243 | Hypothetical protein. (245 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (364 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (254 aa) |
| | fabD | Malonyl CoA-acyl carrier protein transacylase. (309 aa) |
| | pfs | 5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (247 aa) |
| | gltB | Glutamate synthase (NADPH), large chain. (1474 aa) |
| | NIS_1441 | Asparagine synthase, glutamine-hydrolyzing. (567 aa) |
| | gltD | Glutamate synthase (NADPH), small chain. (459 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (285 aa) |
| | NIS_1184 | 3-deoxy-7-phosphoheptulonate synthase, class II. (449 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (264 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa) |
| | lysS | lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (502 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (205 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (340 aa) |
| | NIS_1152 | Thiosulfate sulfurtransferase. (286 aa) |
| | NIS_1140 | Monofunctional class in bifunctional enzyme ThrA/MetL, aspartokinase I/II EC 2.7.2.4/homeserine dehydrogenase I EC 1.1.1.3; Belongs to the aspartokinase family. (402 aa) |
| | dfp | DNA/pantothenate metabolism flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (419 aa) |
| | cysS | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (465 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (349 aa) |
| | argD | Acetylornithine/succinylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (396 aa) |
| | acpS | Holo-[acyl-carrier protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (116 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (284 aa) |
| | thrC | Threonine synthase. (490 aa) |
| | bioA | Adenosylmethionine--8-amino-7-oxononanoate transaminase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (436 aa) |
| | NIS_1470 | Conserved hypothetical protein. (199 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (253 aa) |
| | fabI | Enoyl-[acyl-carrier protein] reductase (NADH). (273 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (232 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (399 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (569 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (871 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (405 aa) |
| | trpC | N terminus of bifunctional TrpC protein, indole-3-glycerol phosphate synthase EC 4.1.1.48/phosphoribosylanthranilate isomerase EC 5.3.1.24 in tryptophan biosynthesis. (262 aa) |
| | NIS_0982 | Chorismate mutase. (99 aa) |
| | NIS_0952 | Ferredoxin--nitrite reductase; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (521 aa) |
| | pgi | Glucose-6-phosphate isomerase; Belongs to the GPI family. (413 aa) |
| | NIS_0934 | Pyruvate/2-oxoglutarate dehydrogenase complex, E1 component, alpha subunit; EC 1.2.4.1/EC 1.2.4.2, PdhA/AceE/SucA OdhA. (323 aa) |
| | NIS_0933 | Pyruvate/2-oxoglutarate dehydrogenase complex, E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (325 aa) |
| | NIS_0932 | Pyruvate/2-oxoglutarate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase; EC 2.3.1.12/EC 2.3.1.61, AceF/SucB OdhB. (408 aa) |
| | NIS_0927 | Fructose-bisphosphate aldolase, class I. (302 aa) |
| | lipA | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (274 aa) |
| | ppsA | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (799 aa) |
| | gpmA | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (230 aa) |
| | NIS_0919 | Conserved hypothetical protein. (425 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (317 aa) |
| | NIS_0890 | Carboxypeptidase G2. (362 aa) |
| | NIS_0887 | Aspartoacylase. (271 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (752 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase, large subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is though [...] (223 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (412 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (323 aa) |
| | mdh | Malate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (318 aa) |
| | NIS_0834 | Isocitrate dehydrogenase, NADP-dependent; Belongs to the monomeric-type IDH family. (738 aa) |
| | hisS | histidyl-tRNA synthetase. (406 aa) |
| | speA | Arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily. (612 aa) |
| | NIS_0816 | Serine O-acetyltransferase. (238 aa) |
| | ilvH | Acetolactate synthase, small subunit. (155 aa) |
| | ilvI | Acetolactate synthase, large subunit. (564 aa) |
| | tdcB | Threonine dehydratase. (401 aa) |
| | gltX1 | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (431 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (632 aa) |
| | NIS_0782 | Acetyltransferase, GNAT family; Belongs to the acetyltransferase family. (157 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase; C terminus of bifunctional HisB protein, histidinol-phosphatase EC 3.1.3.15, N-terminal/imidazoleglycerol-phosphate dehydratase EC 4.2.1.19, C-terminal. (190 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (589 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (399 aa) |
| | NIS_0741 | UDP-glucose 6-dehydrogenase. (455 aa) |
| | NIS_0733 | FAD dependent oxidoreductase. (342 aa) |
| | glyS | glycyl-tRNA synthetase, beta subunit. (678 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (356 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (153 aa) |
| | NIS_0718 | Ni-Fe hydrogenase, membrane subunit HycD/HyfD; Group 4, formate-hydrogen lyase complex FHL subunit 4. (306 aa) |
| | NIS_0717 | Ni-Fe hydrogenase, membrane subunit HyfE; Group 4, formate-hydrogen lyase complex FHL membrane subunit. (195 aa) |
| | folD | 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (282 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (399 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa) |
| | NIS_0698 | 7-alpha-hydroxysteroid dehydrogenase. (254 aa) |
| | NIS_0688 | Succinate dehydrogenase/fumarate reductase, subunit C. (292 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (175 aa) |
| | NIS_0664 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (275 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (433 aa) |
| | pheT | phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (776 aa) |
| | pheS | phenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (326 aa) |
| | NIS_0658 | Histidine triad family protein; HIT family. (119 aa) |
| | argH | Argininosuccinate lyase. (462 aa) |
| | glmS | Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (621 aa) |
| | ispDF | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. (373 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (430 aa) |
| | fbaA | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (358 aa) |
| | NIS_0551 | Conserved hypothetical protein. (209 aa) |
| | metH | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1148 aa) |
| | carB | Carbamoylphosphate synthase, large subunit; Belongs to the CarB family. (1084 aa) |
| | fabZ | 3R-hydroxymyristoyl ACP dehydrase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (148 aa) |
| | NIS_0534 | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (281 aa) |
| | acs | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (650 aa) |
| | NIS_0498 | Diaminopimelate decarboxylase. (443 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (342 aa) |
| | NIS_0439 | Conserved hypothetical protein; Similar to sulfur oxidation protein SoxH. (299 aa) |
| | folK | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. (161 aa) |
| | aroQ | 3-dehydroquinate dehydratase II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (156 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (293 aa) |
| | nadA | Quinolinate synthase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (337 aa) |
| | NIS_0406 | Prephenate dehydrogenase; C terminus of bifunctional TyrA protein, chorismate mutase T EC 5.4.99.5, N-terminal and prephenate dehydrogenase EC 1.3.1.12], C-terminal. (275 aa) |
| | fabH | 3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (332 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (332 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (366 aa) |
| | pheA | Chorismate mutase/prephenate dehydratase; Bifunctional enzyme. (360 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (400 aa) |
| | bioD | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (212 aa) |
| | pyrB | Aspartate carbamoyltransferase, catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (292 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (246 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (259 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (309 aa) |
| | alr | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (332 aa) |
| | glcD | Glycolate oxidase, subunit GlcD. (460 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (352 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (196 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (394 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (311 aa) |
| | fabF | 3-oxoacyl-[acyl-carrier-protein] synthase I/II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (407 aa) |
| | acpP | Acyl carrier protein ACP; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa) |
| | fabG | 3-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa) |
| | panD | Aspartate decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (121 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (357 aa) |
| | gph | HAD-superfamily hydrolase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (218 aa) |
| | NIS_0191 | GDP-mannose 6-dehydrogenase; Alginate biosynthesis protein. (436 aa) |
| | NIS_0190 | Alginate biosynthesis protein Alg8. (521 aa) |
| | NIS_0188 | Hypothetical protein. (885 aa) |
| | pyrG | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (540 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (564 aa) |
| | thrS | threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (613 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (250 aa) |
| | NIS_0096 | Nitrous oxidase accessory protein NosD. (408 aa) |
| | dtd | D-tyrosyl-tRNA deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (147 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (254 aa) |
| | NIS_0025 | Conserved hypothetical protein. (408 aa) |
