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hemB hemB hemN hemN hemE hemE btuR btuR NIS_0204 NIS_0204 NIS_0590 NIS_0590 NIS_0591 NIS_0591 NIS_0669 NIS_0669 hemL hemL hemH hemH purC purC hemC hemC hemA hemA NIS_1142 NIS_1142 NIS_1338 NIS_1338 NIS_1776 NIS_1776 NIS_1777 NIS_1777 NIS_1790 NIS_1790 NIS_1793 NIS_1793
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hemBPorphobilinogen synthase; Belongs to the ALAD family. (321 aa)
hemNOxygen-independent coproporphyrinogen III oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (455 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (340 aa)
btuRcob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (166 aa)
NIS_0204Conserved hypothetical protein. (144 aa)
NIS_0590Von Willebrand factor type A domain protein. (497 aa)
NIS_0591Von Willebrand factor type A domain protein. (289 aa)
NIS_0669Conserved hypothetical protein. (66 aa)
hemLGlutamate-1-semialdehyde 2,1-aminomutase. (427 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (309 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (239 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (310 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (432 aa)
NIS_1142Oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (345 aa)
NIS_1338uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (213 aa)
NIS_1776Transcriptional regulator, AsnC/Lrp family. (330 aa)
NIS_1777Conserved hypothetical protein. (191 aa)
NIS_1790uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (243 aa)
NIS_1793Nitrite reductase (NO-forming), cytochrome d1, heme region. (559 aa)
Your Current Organism:
Nitratiruptor sp. SB1552
NCBI taxonomy Id: 387092
Other names: N. sp. SB155-2, Nitratiruptor sp. SB155-2
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