node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SUN_0168 | SUN_0890 | SUN_0168 | SUN_0890 | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.901 |
SUN_0168 | SUN_1505 | SUN_0168 | SUN_1505 | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Xanthine phosphoribosyltransferase. | 0.904 |
SUN_0168 | SUN_2036 | SUN_0168 | SUN_2036 | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.901 |
SUN_0168 | guaA | SUN_0168 | SUN_1897 | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.970 |
SUN_0168 | guaB | SUN_0168 | SUN_1794 | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.946 |
SUN_0168 | surE | SUN_0168 | SUN_1306 | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Stationary-phase survival protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
SUN_0890 | SUN_0168 | SUN_0890 | SUN_0168 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.901 |
SUN_0890 | SUN_1505 | SUN_0890 | SUN_1505 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Xanthine phosphoribosyltransferase. | 0.900 |
SUN_0890 | SUN_2036 | SUN_0890 | SUN_2036 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.905 |
SUN_0890 | adk-2 | SUN_0890 | SUN_1507 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.913 |
SUN_0890 | apt | SUN_0890 | SUN_0659 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.912 |
SUN_0890 | gmk | SUN_0890 | SUN_2210 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.900 |
SUN_0890 | guaA | SUN_0890 | SUN_1897 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.915 |
SUN_0890 | guaB | SUN_0890 | SUN_1794 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.926 |
SUN_0890 | surE | SUN_0890 | SUN_1306 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Stationary-phase survival protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.911 |
SUN_1505 | SUN_0168 | SUN_1505 | SUN_0168 | Xanthine phosphoribosyltransferase. | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.904 |
SUN_1505 | SUN_0890 | SUN_1505 | SUN_0890 | Xanthine phosphoribosyltransferase. | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.900 |
SUN_1505 | SUN_2036 | SUN_1505 | SUN_2036 | Xanthine phosphoribosyltransferase. | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.900 |
SUN_1505 | adk-2 | SUN_1505 | SUN_1507 | Xanthine phosphoribosyltransferase. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.503 |
SUN_1505 | apt | SUN_1505 | SUN_0659 | Xanthine phosphoribosyltransferase. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.929 |