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| | rimO | tRNA modifying enzyme; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (439 aa) |
| | tilS | tRNA-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. (323 aa) |
| | SUN_2197 | Site-specific recombinase, phage integrase family; Belongs to the 'phage' integrase family. (280 aa) |
| | miaB | tRNA-i(6)A37 thiotransferase enzyme; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (419 aa) |
| | nusA | Transcription termination factor NusA; Participates in both transcription termination and antitermination. (387 aa) |
| | argS | arginyl-tRNA synthetase. (565 aa) |
| | SUN_2213 | uracil-DNA glycosylase; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (233 aa) |
| | miaA | tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (301 aa) |
| | SUN_2234 | Hypothetical protein. (1069 aa) |
| | SUN_2235 | Conserved hypothetical protein; Similar to transposase. (159 aa) |
| | nfo | Endonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. (296 aa) |
| | dnaG | DNA primase DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (550 aa) |
| | rnhA | Ribonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (147 aa) |
| | rnc | Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (223 aa) |
| | rnhB | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (188 aa) |
| | SUN_2263 | Hypothetical protein. (300 aa) |
| | SUN_2264 | Hypothetical protein. (633 aa) |
| | SUN_2265 | Conserved hypothetical protein; Similar to transposase. (158 aa) |
| | recQ | ATP-dependent DNA helicase RecQ. (592 aa) |
| | SUN_2294 | Site-specific recombinase, phage integrase family; Belongs to the 'phage' integrase family. (379 aa) |
| | rpoA | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (333 aa) |
| | SUN_2362 | ATPase, AAA family. (393 aa) |
| | SUN_2363 | RNA pseudouridine synthase; Belongs to the pseudouridine synthase RsuA family. (281 aa) |
| | rnj | Conserved hypothetical protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (701 aa) |
| | ksgA | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (284 aa) |
| | rlmN | Conserved hypothetical protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (359 aa) |
| | SUN_2370 | Ribosomal large subunit pseudouridine synthase, RluD subfamily. (309 aa) |
| | nrdA | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (789 aa) |
| | SUN_2398 | Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (339 aa) |
| | SUN_2412 | Site-specific recombinase, phage integrase family; Belongs to the 'phage' integrase family. (409 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). (604 aa) |
| | vsr | DNA mismatch endonuclease Vsr; May nick specific sequences that contain T:G mispairs resulting from m5C-deamination. (137 aa) |
| | SUN_2431 | Endonuclease. (923 aa) |
| | SUN_2433 | Conserved hypothetical protein. (684 aa) |
| | SUN_2434 | 5-methylcytosine-specific restriction enzyme A. (225 aa) |
| | SUN_2438 | Cytosine-specific methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (362 aa) |
| | SUN_2445 | Phage-related protein. (115 aa) |
| | SUN_2446 | DNA relaxase TraI. (535 aa) |
| | SUN_2452 | Site-specific recombinase, phage integrase family; Belongs to the 'phage' integrase family. (366 aa) |
| | SUN_2453 | Transposase. (401 aa) |
| | ruvC | Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (159 aa) |
| | dnaA | Chromosome replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (442 aa) |
| | dnaN | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (355 aa) |
| | recJ | Single-strand DNA-specific exonuclease. (527 aa) |
| | SUN_0008 | Conserved hypothetical protein. (128 aa) |
| | SUN_0010 | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. (326 aa) |
| | SUN_0071 | Conserved hypothetical protein. (228 aa) |
| | recA | DNA recombination protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (347 aa) |
| | topA | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (732 aa) |
| | SUN_0107 | DNA uptake protein. (111 aa) |
| | gltX1 | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (462 aa) |
| | nusG | Transcriptional antitermination factor NusG; Participates in transcription elongation, termination and antitermination. (176 aa) |
| | rpoB | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1385 aa) |
| | rpoC | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1509 aa) |
| | gyrB | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (773 aa) |
| | tsaD | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (337 aa) |
| | SUN_0149 | Conserved hypothetical protein. (122 aa) |
| | SUN_0185 | Conserved hypothetical protein. (776 aa) |
| | SUN_0186 | Conserved hypothetical protein. (193 aa) |
| | SUN_0204 | Conserved hypothetical protein. (255 aa) |
| | gidA | Glucose inhibited division protein A; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. (623 aa) |
| | SUN_0218 | Conserved hypothetical protein; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (223 aa) |
| | rsmI | Conserved hypothetical protein; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (270 aa) |
| | SUN_0222 | RNA methyltransferase, TrmH family; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (234 aa) |
| | SUN_0231 | Conserved hypothetical protein; Belongs to the UPF0102 family. (113 aa) |
| | SUN_0252 | Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (337 aa) |
| | nrdD | Anaerobic ribonucleoside triphosphate reductase. (698 aa) |
| | SUN_0256 | Conserved hypothetical protein. (57 aa) |
| | SUN_0338 | Conserved hypothetical protein. (226 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (857 aa) |
| | glyQ | glycyl-tRNA synthetase, alpha subunit. (294 aa) |
| | SUN_0365 | Ribosomal large subunit pseudouridine synthase, RluD subfamily. (245 aa) |
| | rimM | 16S rRNA processing protein RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (178 aa) |
| | trmD | tRNA (guanine-N1-)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (227 aa) |
| | truB | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (277 aa) |
| | mutS2 | DNA mismatch repair protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (738 aa) |
| | xerD | Site-specific DNA tyrosine recombinase XerD; Belongs to the 'phage' integrase family. (271 aa) |
| | ssb | Single strand DNA binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (165 aa) |
| | SUN_0430 | Conserved hypothetical protein. (325 aa) |
| | SUN_0431 | Ribonuclease; Belongs to the RNR ribonuclease family. (655 aa) |
| | SUN_0437 | Transposase. (450 aa) |
| | SUN_0448 | Conserved hypothetical protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family. (128 aa) |
| | rppH | (di)nucleoside polyphosphate hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. (157 aa) |
| | SUN_0458 | DNA polymerase III, delta' subunit. (205 aa) |
| | ligA | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (648 aa) |
| | SUN_0462 | Hemolysin A. (237 aa) |
| | cmoA | Methyltransferase; Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM). (235 aa) |
| | SUN_0474 | Hypothetical protein. (233 aa) |
| | SUN_0478 | Transposase. (375 aa) |
| | lysS | lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (547 aa) |
| | pheS | phenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (330 aa) |
| | pheT | phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (777 aa) |
| | thiJ | 4-methyl-5(beta-hydroxyethyl)-thiazole monophosphate synthesis protein. (186 aa) |
| | dnaE | DNA polymerase III, alpha subunit. (1188 aa) |
| | radA | DNA repair protein RadA/Sms; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (450 aa) |
| | rny | Conserved hypothetical protein; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. (509 aa) |
| | cmoB | Conserved hypothetical protein; Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L- methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5- carboxymethoxyuridine (cmo5U) at position 34 in tRNAs. (301 aa) |
| | SUN_0609 | Conserved hypothetical protein. (175 aa) |
| | apaH | Bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. (279 aa) |
| | rsmH | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (307 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (568 aa) |
| | xthA | Exodeoxyribonuclease III. (256 aa) |
| | SUN_0661 | Hypothetical protein. (177 aa) |
| | SUN_0677 | Transposase. (336 aa) |
| | SUN_0699 | Conserved hypothetical protein. (127 aa) |
| | SUN_0702 | Conserved hypothetical protein. (106 aa) |
| | SUN_0713 | ATP-dependent RNA helicase. (447 aa) |
| | SUN_0714 | Conserved hypothetical protein. (249 aa) |
| | SUN_0719 | RNA methyltransferase, TrmA family; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (263 aa) |
| | SUN_0725 | DNA double-strand break repair protein. (373 aa) |
| | SUN_0726 | DNA double-strand break repair protein. (788 aa) |
| | SUN_0728 | Transposase. (440 aa) |
| | SUN_0735 | Conserved hypothetical protein; Similar to transposase. (256 aa) |
| | SUN_0745 | Ribosomal small subunit pseudouridine synthase A; Belongs to the pseudouridine synthase RsuA family. (188 aa) |
| | SUN_0749 | Mutator family transposase; Required for the transposition of the insertion element. (401 aa) |
| | SUN_0813 | Hypothetical protein. (117 aa) |
| | SUN_0817 | Hypothetical protein. (369 aa) |
| | cysS | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (465 aa) |
| | ruvA | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (185 aa) |
| | SUN_0837 | GTP-binding protein. (158 aa) |
| | SUN_0865 | Conserved hypothetical protein. (479 aa) |
| | SUN_0872 | Transposase. (222 aa) |
| | SUN_0873 | Transposase; Required for the transposition of the insertion element. (106 aa) |
| | SUN_0906 | Conserved hypothetical protein. (195 aa) |
| | hrpB | ATP-dependent helicase HrpB. (827 aa) |
| | SUN_0915 | Conserved hypothetical protein. (582 aa) |
| | SUN_0951 | methylated-DNA-[protein]-cysteine S-methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (176 aa) |
| | cca | Polynucleotide adenylyltransferase/metal-dependent phosphohydrolase; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (485 aa) |
| | SUN_0981 | Conserved hypothetical protein; Belongs to the RNase T2 family. (361 aa) |
| | SUN_0982 | Conserved hypothetical protein. (429 aa) |
| | SUN_0994 | DNA polymerase IV, family X. (571 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] (373 aa) |
| | SUN_1012 | tRNA modifying enzyme. (417 aa) |
| | SUN_1019 | Conserved hypothetical protein. (85 aa) |
| | SUN_1021 | Conserved hypothetical protein; Similar to transposase. (255 aa) |
| | SUN_1025 | Conserved hypothetical protein; Similar to transposase. (177 aa) |
| | trmU | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (340 aa) |
| | SUN_1076 | Exonuclease. (244 aa) |
| | SUN_1093 | Y1_Tnp domain-containing protein; Probable gene remnant. Similar to the N-terminal region of Campylobacter jejuni RM1221 type I restriction-modification enzyme, subunit M HsdM (494 aa) CJE1724. (156 aa) |
| | trmH | tRNA (guanosine-2'-O-)-methyltransferase; Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (216 aa) |
| | SUN_1106 | Conserved hypothetical protein. (146 aa) |
| | queH | Conserved hypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (360 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (649 aa) |
| | SUN_1130 | Conserved hypothetical protein. (84 aa) |
| | gltX2 | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (428 aa) |
| | glnS | glutaminyl-tRNA synthetase. (749 aa) |
| | dnaQ | DNA polymerase III, epsilon subunit. (206 aa) |
| | SUN_1176 | Hypothetical protein. (122 aa) |
| | SUN_1181 | DNA methylase. (203 aa) |
| | SUN_1182 | Conserved hypothetical protein. (249 aa) |
| | SUN_1183 | Cytidine/deoxycytidylate deaminase family protein. (153 aa) |
| | truD | tRNA pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. (355 aa) |
| | SUN_1197 | Endonuclease III. (202 aa) |
| | SUN_1216 | HNHc domain-containing protein; Probable gene remnant. Similar to the N- and C-terminal region of Desulfovibrio desulfuricans G20 ISPg7, transposase (438 aa) Dde_2849. This CDS appears to have a frameshift mutation following codon 210. (287 aa) |
| | SUN_1230 | Hydrolase, TatD family. (256 aa) |
| | recN | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (512 aa) |
| | truD-2 | tRNA pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. (362 aa) |
| | ybeY | Conserved hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (147 aa) |
| | SUN_1294 | RNA-metabolising metallo-beta-lactamase. (467 aa) |
| | SUN_1301 | Conserved hypothetical protein; Similar to transposase. (256 aa) |
| | SUN_1307 | Conserved hypothetical protein. (211 aa) |
| | SUN_1311 | Conserved hypothetical protein; Similar to signal transduction protein (sensory box protein). (171 aa) |
| | SUN_1314 | Type II restriction-modification enzyme, R and M protein. (1232 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (898 aa) |
| | uvrA | Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (941 aa) |
| | SUN_1320 | tRNA-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (318 aa) |
| | rlmH | Conserved hypothetical protein; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (153 aa) |
| | hisS | histidyl-tRNA synthetase. (403 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (878 aa) |
| | SUN_1378 | DNA polymerase IV; Belongs to the DNA polymerase type-Y family. (422 aa) |
| | SUN_1438 | Site-specific recombinase, phage integrase family; Belongs to the 'phage' integrase family. (366 aa) |
| | rnz | Ribonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (317 aa) |
| | SUN_1456 | Conserved hypothetical protein. (321 aa) |
| | thiI | Thiamin biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (486 aa) |
| | SUN_1483 | DNA recombination protein. (515 aa) |
| | SUN_1494 | Conserved hypothetical protein. (258 aa) |
| | SUN_1496 | Conserved hypothetical protein; Similar to transposase. (177 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (584 aa) |
| | SUN_1525 | Conserved hypothetical protein. (256 aa) |
| | SUN_1543 | Hypothetical protein. (327 aa) |
| | SUN_1545 | Conserved hypothetical protein. (140 aa) |
| | SUN_1563 | tRNA/rRNA methyltransferase. (258 aa) |
| | mnmE | tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (450 aa) |
| | SUN_1572 | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (96 aa) |
| | SUN_1583 | Conserved hypothetical protein. (252 aa) |
| | SUN_1585 | Conserved hypothetical protein. (135 aa) |
| | SUN_1599 | Exonuclease. (263 aa) |
| | SUN_1607 | MoaA/NifB/PqqE family protein. (304 aa) |
| | gyrA | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (840 aa) |
| | glyS | glycyl-tRNA synthetase, beta subunit. (682 aa) |
| | trmL | tRNA/rRNA methyltransferase; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. (164 aa) |
| | rpoD | RNA polymerase sigma 70 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (612 aa) |
| | SUN_1729 | Transposase. (143 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (399 aa) |
| | rpoZ | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (68 aa) |
| | trmB | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (395 aa) |
| | rluD | Ribosomal large subunit pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (317 aa) |
| | SUN_1754 | Conserved hypothetical protein; Belongs to the TtcA family. (265 aa) |
| | fmt | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (304 aa) |
| | xseB | Exodeoxyribonuclease VII, small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (70 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (918 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (216 aa) |
| | selU | Rhodanese family protein; Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2- selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain. (364 aa) |
| | trmA | tRNA (uracil-5-)-methyltransferase; Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA). (371 aa) |
| | truA | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (240 aa) |
| | SUN_1850 | Conserved hypothetical protein. (514 aa) |
| | SUN_1865 | Conserved hypothetical protein. (509 aa) |
| | SUN_1876 | Conserved hypothetical protein. (348 aa) |
| | recR | DNA recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (189 aa) |
| | dnaJ | Co-chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ [...] (377 aa) |
| | pnp | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (729 aa) |
| | SUN_1888 | Heat shock protein. (89 aa) |
| | uvrC | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (598 aa) |
| | recG | ATP-dependent DNA recombinase RecG. (602 aa) |
| | nusB | Transcription antitermination factor NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (130 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (319 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (441 aa) |
| | SUN_1937 | Transposase; Required for the transposition of the insertion element. (401 aa) |
| | SUN_1938 | Hypothetical protein. (144 aa) |
| | SUN_1955 | Transposase. (440 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (414 aa) |
| | xseA | Exodeoxyribonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (422 aa) |
| | rbfA | Ribosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. (129 aa) |
| | SUN_1976 | Transposase. (440 aa) |
| | SUN_1978 | Phosphoesterase. (332 aa) |
| | mfd | Transcription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (994 aa) |
| | leuS | leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (813 aa) |
| | dnaX | DNA polymerase III, gamma/tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (666 aa) |
| | gidB | Glucose inhibited division protein B; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. (193 aa) |
| | ruvB | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (337 aa) |
| | SUN_2108 | Probable gene remnant. Similar to the C-terminal region of Desulfotalea psychrophila LSv54 prophage integrase (399 aa) DP0425. (450 aa) |
| | SUN_2109 | Conserved hypothetical protein. (2052 aa) |
| | SUN_2115 | Hypothetical protein. (268 aa) |
| | SUN_2120 | Conserved hypothetical protein. (89 aa) |
| | SUN_2133 | Replicative DNA helicase DnaB, intein-containing; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (822 aa) |
| | priA | Primosomal replication factor Y; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (622 aa) |
| | uvrB | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (657 aa) |
| | SUN_2154 | DNA polymerase III, epsilon subunit. (272 aa) |
| | SUN_2182 | RNA-metabolising metallo-beta-lactamase. (466 aa) |
