(10 nodes) Activation of caspases through apoptosome-mediated cleavage, and Transmembrane protein 198 network (Gopherus agassizii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSGAGP00000003711	RING-type domain-containing protein. (224 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (423 aa)
	ENSGAGP00000010941	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (309 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (282 aa)
	TMEM198	Transmembrane protein 198. (358 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1251 aa)
	ENSGAGP00000024079	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	ENSGAGP00000029809	Uncharacterized protein. (242 aa)
	XIAP	X-linked inhibitor of apoptosis. (496 aa)

Your Current Organism:

Gopherus agassizii

NCBI taxonomy Id: 38772
Other names: G. agassizii, Gopherus agassizi, Gopherus polyphemus agassizii, USNM 7888, desert tortoise

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	CASP3	ENSGAGP00000022750	ENSGAGP00000021424	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 3; Belongs to the peptidase C14A family.	0.979
APAF1	CASP7	ENSGAGP00000022750	ENSGAGP00000013610	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 7; Belongs to the peptidase C14A family.	0.967
APAF1	CASP9	ENSGAGP00000022750	ENSGAGP00000009292	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.997
APAF1	ENSGAGP00000003711	ENSGAGP00000022750	ENSGAGP00000003711	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	RING-type domain-containing protein.	0.801
APAF1	ENSGAGP00000010941	ENSGAGP00000022750	ENSGAGP00000010941	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.998
APAF1	ENSGAGP00000024079	ENSGAGP00000022750	ENSGAGP00000024079	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.998
APAF1	ENSGAGP00000029809	ENSGAGP00000022750	ENSGAGP00000029809	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.875
APAF1	TMEM198	ENSGAGP00000022750	ENSGAGP00000021452	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Transmembrane protein 198.	0.942
APAF1	XIAP	ENSGAGP00000022750	ENSGAGP00000034114	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	X-linked inhibitor of apoptosis.	0.901
CASP3	APAF1	ENSGAGP00000021424	ENSGAGP00000022750	Caspase 3; Belongs to the peptidase C14A family.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.979
CASP3	CASP7	ENSGAGP00000021424	ENSGAGP00000013610	Caspase 3; Belongs to the peptidase C14A family.	Caspase 7; Belongs to the peptidase C14A family.	0.849
CASP3	CASP9	ENSGAGP00000021424	ENSGAGP00000009292	Caspase 3; Belongs to the peptidase C14A family.	Caspase 9; Belongs to the peptidase C14A family.	0.967
CASP3	ENSGAGP00000003711	ENSGAGP00000021424	ENSGAGP00000003711	Caspase 3; Belongs to the peptidase C14A family.	RING-type domain-containing protein.	0.930
CASP3	ENSGAGP00000010941	ENSGAGP00000021424	ENSGAGP00000010941	Caspase 3; Belongs to the peptidase C14A family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.908
CASP3	ENSGAGP00000024079	ENSGAGP00000021424	ENSGAGP00000024079	Caspase 3; Belongs to the peptidase C14A family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.870
CASP3	ENSGAGP00000029809	ENSGAGP00000021424	ENSGAGP00000029809	Caspase 3; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.723
CASP3	TMEM198	ENSGAGP00000021424	ENSGAGP00000021452	Caspase 3; Belongs to the peptidase C14A family.	Transmembrane protein 198.	0.531
CASP3	XIAP	ENSGAGP00000021424	ENSGAGP00000034114	Caspase 3; Belongs to the peptidase C14A family.	X-linked inhibitor of apoptosis.	0.992
CASP7	APAF1	ENSGAGP00000013610	ENSGAGP00000022750	Caspase 7; Belongs to the peptidase C14A family.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.967
CASP7	CASP3	ENSGAGP00000013610	ENSGAGP00000021424	Caspase 7; Belongs to the peptidase C14A family.	Caspase 3; Belongs to the peptidase C14A family.	0.849