(59 nodes) Mixed, incl. Helix-loop-helix DNA-binding domain superfamily, and Regulation of expression of SLITs and ROBOs network (Gopherus agassizii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	OTP	Orthopedia homeobox. (325 aa)
	ENSGAGP00000000131	LisH domain-containing protein. (117 aa)
	MYOD1	Myogenic factor. (290 aa)
	TCF23	Transcription factor 23. (168 aa)
	RAX	Retina and anterior neural fold homeobox. (235 aa)
	UNCX	UNC homeobox. (406 aa)
	LHX4	LIM homeobox 4. (374 aa)
	LHX5	LIM homeobox 5. (402 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (206 aa)
	FIGLA	Folliculogenesis specific bHLH transcription factor. (206 aa)
	ENSGAGP00000004681	Uncharacterized protein. (69 aa)
	ENSGAGP00000006901	Uncharacterized protein. (308 aa)
	TCF12	Transcription factor 12. (734 aa)
	TCF24	Transcription factor 24. (165 aa)
	ENSGAGP00000011074	Uncharacterized protein. (349 aa)
	ENSGAGP00000011083	Uncharacterized protein. (188 aa)
	LMX1B	LIM homeobox transcription factor 1 beta. (404 aa)
	LHX2	LIM homeobox 2. (437 aa)
	TAL2	TAL bHLH transcription factor 2. (117 aa)
	ID4	Inhibitor of DNA binding 4, HLH protein. (157 aa)
	HELT	Helt bHLH transcription factor. (239 aa)
	ENSGAGP00000014142	BHLH domain-containing protein. (152 aa)
	LHX3	LIM homeobox 3. (395 aa)
	LMO4	LIM domain only 4. (165 aa)
	ENSGAGP00000015471	BHLH domain-containing protein. (308 aa)
	ENSGAGP00000015472	BHLH domain-containing protein. (341 aa)
	BARX1	BARX homeobox 1. (247 aa)
	LMO3	LIM domain only 3. (156 aa)
	TCF3	Transcription factor 3. (672 aa)
	SSBP3	Single stranded DNA binding protein 3. (396 aa)
	ASCL3	Achaete-scute family bHLH transcription factor 3. (173 aa)
	LDB1	LIM domain binding 1. (411 aa)
	ID2	Inhibitor of DNA binding 2. (134 aa)
	ENSGAGP00000020678	Uncharacterized protein. (50 aa)
	SSBP2	Single stranded DNA binding protein 2. (360 aa)
	BARHL2	BarH like homeobox 2. (370 aa)
	TCF4	Transcription factor 4. (537 aa)
	ID3	Inhibitor of DNA binding 3, HLH protein. (125 aa)
	MYF6	Myogenic factor 6. (242 aa)
	MYF5	Myogenic factor. (254 aa)
	LMO1	LIM domain only 1. (156 aa)
	FERD3L	Fer3 like bHLH transcription factor. (163 aa)
	LHX6	LIM homeobox 6. (380 aa)
	NHLH1	Nescient helix-loop-helix 1. (136 aa)
	VAX1	Ventral anterior homeobox 1. (319 aa)
	ALX3	ALX homeobox 3. (290 aa)
	ID1	Inhibitor of DNA binding 1, HLH protein. (146 aa)
	TCF21	Transcription factor 21. (179 aa)
	DRGX	Dorsal root ganglia homeobox. (260 aa)
	LDB2	LIM domain binding 2. (349 aa)
	NHLH2	Nescient helix-loop-helix 2. (135 aa)
	ENSGAGP00000031315	BHLH domain-containing protein. (157 aa)
	ENSGAGP00000031375	Uncharacterized protein. (133 aa)
	ENSGAGP00000034594	LIM zinc-binding domain-containing protein. (84 aa)
	ENSGAGP00000034595	Uncharacterized protein. (143 aa)
	LHX9	LIM homeobox 9. (378 aa)
	ENSGAGP00000035529	Homeobox domain-containing protein. (183 aa)
	ISL2	ISL LIM homeobox 2. (186 aa)
	MYOG	Myogenin. (227 aa)

Your Current Organism:

Gopherus agassizii

NCBI taxonomy Id: 38772
Other names: G. agassizii, Gopherus agassizi, Gopherus polyphemus agassizii, USNM 7888, desert tortoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALX3	ASCL1	ENSGAGP00000026092	ENSGAGP00000004134	ALX homeobox 3.	Achaete-scute family bHLH transcription factor 1.	0.517
ALX3	ASCL3	ENSGAGP00000026092	ENSGAGP00000019897	ALX homeobox 3.	Achaete-scute family bHLH transcription factor 3.	0.421
ALX3	BARX1	ENSGAGP00000026092	ENSGAGP00000016572	ALX homeobox 3.	BARX homeobox 1.	0.431
ALX3	ENSGAGP00000015471	ENSGAGP00000026092	ENSGAGP00000015471	ALX homeobox 3.	BHLH domain-containing protein.	0.406
ALX3	ENSGAGP00000020678	ENSGAGP00000026092	ENSGAGP00000020678	ALX homeobox 3.	Uncharacterized protein.	0.511
ALX3	FERD3L	ENSGAGP00000026092	ENSGAGP00000024793	ALX homeobox 3.	Fer3 like bHLH transcription factor.	0.442
ALX3	LDB1	ENSGAGP00000026092	ENSGAGP00000020235	ALX homeobox 3.	LIM domain binding 1.	0.762
ALX3	LDB2	ENSGAGP00000026092	ENSGAGP00000031016	ALX homeobox 3.	LIM domain binding 2.	0.762
ALX3	LHX3	ENSGAGP00000026092	ENSGAGP00000014374	ALX homeobox 3.	LIM homeobox 3.	0.775
ALX3	LHX4	ENSGAGP00000026092	ENSGAGP00000003099	ALX homeobox 3.	LIM homeobox 4.	0.775
ALX3	NHLH1	ENSGAGP00000026092	ENSGAGP00000025068	ALX homeobox 3.	Nescient helix-loop-helix 1.	0.406
ALX3	NHLH2	ENSGAGP00000026092	ENSGAGP00000031214	ALX homeobox 3.	Nescient helix-loop-helix 2.	0.406
ALX3	TCF12	ENSGAGP00000026092	ENSGAGP00000009957	ALX homeobox 3.	Transcription factor 12.	0.511
ALX3	TCF21	ENSGAGP00000026092	ENSGAGP00000030510	ALX homeobox 3.	Transcription factor 21.	0.412
ALX3	TCF3	ENSGAGP00000026092	ENSGAGP00000018064	ALX homeobox 3.	Transcription factor 3.	0.511
ALX3	TCF4	ENSGAGP00000026092	ENSGAGP00000022404	ALX homeobox 3.	Transcription factor 4.	0.511
ASCL1	ALX3	ENSGAGP00000004134	ENSGAGP00000026092	Achaete-scute family bHLH transcription factor 1.	ALX homeobox 3.	0.517
ASCL1	ENSGAGP00000006901	ENSGAGP00000004134	ENSGAGP00000006901	Achaete-scute family bHLH transcription factor 1.	Uncharacterized protein.	0.540
ASCL1	ENSGAGP00000011074	ENSGAGP00000004134	ENSGAGP00000011074	Achaete-scute family bHLH transcription factor 1.	Uncharacterized protein.	0.540
ASCL1	ENSGAGP00000011083	ENSGAGP00000004134	ENSGAGP00000011083	Achaete-scute family bHLH transcription factor 1.	Uncharacterized protein.	0.540