(34 nodes) Response to gamma radiation network (Gopherus agassizii)

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	BCL2	BCL2 apoptosis regulator. (220 aa)
	TLK2	Tousled like kinase 2. (811 aa)
	ENSGAGP00000006115	CMP/dCMP-type deaminase domain-containing protein. (201 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (446 aa)
	ENSGAGP00000007472	TAN domain-containing protein. (303 aa)
	ENSGAGP00000008121	BRCT domain-containing protein. (167 aa)
	ENSGAGP00000008336	CMP/dCMP-type deaminase domain-containing protein. (276 aa)
	ENSGAGP00000008378	BRCT domain-containing protein. (167 aa)
	ENSGAGP00000008401	Uncharacterized protein. (131 aa)
	XRCC5	X-ray repair cross complementing 5. (770 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (659 aa)
	DCUN1D3	DCN1-like protein. (304 aa)
	PML	Promyelocytic leukemia. (772 aa)
	ENSGAGP00000012449	Uncharacterized protein. (568 aa)
	POLB	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (365 aa)
	ENSGAGP00000013929	Uncharacterized protein. (397 aa)
	ENSGAGP00000016195	Uncharacterized protein. (275 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1164 aa)
	TMEM109	Transmembrane protein 109. (242 aa)
	FANCD2	FA complementation group D2. (1451 aa)
	XRCC2	X-ray repair cross complementing 2. (278 aa)
	XRCC6	X-ray repair cross complementing 6. (610 aa)
	ENSGAGP00000024027	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1974 aa)
	KDM1A	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (850 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (467 aa)
	WRN	WRN RecQ like helicase. (1488 aa)
	MAP3K20	Mitogen-activated protein kinase kinase kinase 20. (797 aa)
	ERCC6	ERCC excision repair 6, chromatin remodeling factor. (1372 aa)
	BRCA2	BRCA2 DNA repair associated. (3571 aa)
	ENSGAGP00000030142	CMP/dCMP-type deaminase domain-containing protein. (271 aa)
	MEN1	Menin 1. (501 aa)
	MYC	MYC proto-oncogene, bHLH transcription factor. (472 aa)
	CRYAB	Crystallin alpha B; Belongs to the small heat shock protein (HSP20) family. (174 aa)
	BAK1	BCL2 antagonist/killer 1. (211 aa)

Your Current Organism:

Gopherus agassizii

NCBI taxonomy Id: 38772
Other names: G. agassizii, Gopherus agassizi, Gopherus polyphemus agassizii, USNM 7888, desert tortoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAK1	BCL2	ENSGAGP00000026831	ENSGAGP00000024435	BCL2 antagonist/killer 1.	BCL2 apoptosis regulator.	0.986
BAK1	TP53	ENSGAGP00000026831	ENSGAGP00000006237	BCL2 antagonist/killer 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.969
BCL2	BAK1	ENSGAGP00000024435	ENSGAGP00000026831	BCL2 apoptosis regulator.	BCL2 antagonist/killer 1.	0.986
BCL2	MYC	ENSGAGP00000024435	ENSGAGP00000029754	BCL2 apoptosis regulator.	MYC proto-oncogene, bHLH transcription factor.	0.457
BCL2	TP53	ENSGAGP00000024435	ENSGAGP00000006237	BCL2 apoptosis regulator.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.988
BCL2	XRCC6	ENSGAGP00000024435	ENSGAGP00000023956	BCL2 apoptosis regulator.	X-ray repair cross complementing 6.	0.527
BRCA2	ENSGAGP00000007472	ENSGAGP00000032128	ENSGAGP00000007472	BRCA2 DNA repair associated.	TAN domain-containing protein.	0.855
BRCA2	ENSGAGP00000008121	ENSGAGP00000032128	ENSGAGP00000008121	BRCA2 DNA repair associated.	BRCT domain-containing protein.	0.462
BRCA2	ENSGAGP00000008378	ENSGAGP00000032128	ENSGAGP00000008378	BRCA2 DNA repair associated.	BRCT domain-containing protein.	0.462
BRCA2	ENSGAGP00000008401	ENSGAGP00000032128	ENSGAGP00000008401	BRCA2 DNA repair associated.	Uncharacterized protein.	0.855
BRCA2	ENSGAGP00000013929	ENSGAGP00000032128	ENSGAGP00000013929	BRCA2 DNA repair associated.	Uncharacterized protein.	0.470
BRCA2	ENSGAGP00000024027	ENSGAGP00000032128	ENSGAGP00000024027	BRCA2 DNA repair associated.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.470
BRCA2	FANCD2	ENSGAGP00000032128	ENSGAGP00000023049	BRCA2 DNA repair associated.	FA complementation group D2.	0.992
BRCA2	TP53	ENSGAGP00000032128	ENSGAGP00000006237	BRCA2 DNA repair associated.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.906
BRCA2	WRN	ENSGAGP00000032128	ENSGAGP00000031531	BRCA2 DNA repair associated.	WRN RecQ like helicase.	0.990
BRCA2	XRCC2	ENSGAGP00000032128	ENSGAGP00000023547	BRCA2 DNA repair associated.	X-ray repair cross complementing 2.	0.868
BRCA2	XRCC5	ENSGAGP00000032128	ENSGAGP00000008837	BRCA2 DNA repair associated.	X-ray repair cross complementing 5.	0.705
BRCA2	XRCC6	ENSGAGP00000032128	ENSGAGP00000023956	BRCA2 DNA repair associated.	X-ray repair cross complementing 6.	0.702
CRYAB	MEN1	ENSGAGP00000028499	ENSGAGP00000030057	Crystallin alpha B; Belongs to the small heat shock protein (HSP20) family.	Menin 1.	0.506
CRYAB	TP53	ENSGAGP00000028499	ENSGAGP00000006237	Crystallin alpha B; Belongs to the small heat shock protein (HSP20) family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.499