(84 nodes) Glycosaminoglycan metabolic process network (Gopherus agassizii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSGAGP00000000697	SLT domain-containing protein. (209 aa)
	PGLYRP2	Peptidoglycan recognition protein 2. (522 aa)
	HS3ST3B1	Sulfotransferase; Belongs to the sulfotransferase 1 family. (357 aa)
	B3GALT6	Hexosyltransferase. (316 aa)
	CHST13	Carbohydrate sulfotransferase. (319 aa)
	NDST1	N-deacetylase and N-sulfotransferase 1. (877 aa)
	ENSGAGP00000004075	Carbohydrate sulfotransferase. (88 aa)
	ENSGAGP00000004115	Uncharacterized protein. (356 aa)
	CSGALNACT2	Hexosyltransferase. (542 aa)
	HAS2	Hyaluronan synthase 2. (552 aa)
	ENSGAGP00000004821	Uncharacterized protein. (184 aa)
	GLCE	Glucuronic acid epimerase. (617 aa)
	ENSGAGP00000005737	ITI_HC_C domain-containing protein. (487 aa)
	CSGALNACT1	Hexosyltransferase. (530 aa)
	HS3ST4	Sulfotransferase; Belongs to the sulfotransferase 1 family. (414 aa)
	DSEL	Dermatan sulfate epimerase like. (1216 aa)
	ENSGAGP00000007738	Hyaluronidase. (380 aa)
	IMPAD1	Inositol monophosphatase domain containing 1. (356 aa)
	B4GALT4	Beta-1,4-galactosyltransferase 4. (353 aa)
	HAS1	Hyaluronan synthase 1. (609 aa)
	CHST11	Carbohydrate sulfotransferase. (218 aa)
	HYAL4	Hyaluronidase. (500 aa)
	ENSGAGP00000010961	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (437 aa)
	ITIH6	Inter-alpha-trypsin inhibitor heavy chain family member 6. (1127 aa)
	HS3ST2	Sulfotransferase; Belongs to the sulfotransferase 1 family. (360 aa)
	ARSK	Arylsulfatase family member K. (578 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (421 aa)
	CHPF	Hexosyltransferase. (725 aa)
	ENSGAGP00000012415	Uncharacterized protein. (195 aa)
	CHSY1	Hexosyltransferase. (800 aa)
	SGSH	N-sulfoglucosamine sulfohydrolase. (415 aa)
	HAS3	Hyaluronan synthase 3. (548 aa)
	TNFAIP6	TNF alpha induced protein 6. (277 aa)
	ENSGAGP00000013894	Uncharacterized protein. (263 aa)
	CLN6	CLN6 transmembrane ER protein. (316 aa)
	CHST1	Sulfotransferase; Belongs to the sulfotransferase 1 family. (419 aa)
	IDUA	Iduronidase alpha-L-. (626 aa)
	CHST2	Sulfotransferase; Belongs to the sulfotransferase 1 family. (418 aa)
	ENSGAGP00000015183	Beta-hexosaminidase. (506 aa)
	UGDH	UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (469 aa)
	HEXB	Beta-hexosaminidase. (539 aa)
	ENSGAGP00000016729	Uncharacterized protein. (134 aa)
	ENSGAGP00000016914	Uncharacterized protein. (879 aa)
	ENSGAGP00000017007	G8 domain-containing protein. (1307 aa)
	CEMIP	Cell migration inducing hyaluronidase 1. (1354 aa)
	ENSGAGP00000017857	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. (504 aa)
	HYAL3	Hyaluronidase. (508 aa)
	HS3ST6	Sulfotransferase; Belongs to the sulfotransferase 1 family. (203 aa)
	XYLT2	Xylosyltransferase 2. (829 aa)
	ENSGAGP00000019898	Hyaluronidase. (562 aa)
	ENSGAGP00000019942	DUF4962 domain-containing protein. (959 aa)
	CHST3	Sulfotransferase; Belongs to the sulfotransferase 1 family. (459 aa)
	ITIH5	Inter-alpha-trypsin inhibitor heavy chain 5. (949 aa)
	ITIH2	Inter-alpha-trypsin inhibitor heavy chain 2. (908 aa)
	HPSE	Heparanase. (526 aa)
	ENSGAGP00000020602	Uncharacterized protein. (556 aa)
	EXT2	Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (718 aa)
	HYAL1	Hyaluronidase. (443 aa)
	DCN	Decorin; May affect the rate of fibrils formation. (356 aa)
	ENSGAGP00000022164	Sulfatase domain-containing protein. (525 aa)
	CHST7	Sulfotransferase; Belongs to the sulfotransferase 1 family. (480 aa)
	B3GAT3	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (338 aa)
	CEMIP2	Cell migration inducing hyaluronidase 2. (1381 aa)
	CHST14	Carbohydrate sulfotransferase. (232 aa)
	ENSGAGP00000024870	Uncharacterized protein. (274 aa)
	NDST4	N-deacetylase and N-sulfotransferase 4. (873 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
	PXYLP1	2-phosphoxylose phosphatase 1; Belongs to the histidine acid phosphatase family. (479 aa)
	HS3ST3A1	Sulfotransferase; Belongs to the sulfotransferase 1 family. (376 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (435 aa)
	NDNF	Neuron derived neurotrophic factor. (569 aa)
	NDST3	N-deacetylase and N-sulfotransferase 3. (873 aa)
	XYLT1	Xylosyltransferase 1. (840 aa)
	SLC10A7	Sodium/bile acid cotransporter; Does not show transport activity towards bile acids or steroid sulfates; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. (345 aa)
	CHSY3	Hexosyltransferase. (361 aa)
	ITIH3	Inter-alpha-trypsin inhibitor heavy chain 3. (878 aa)
	MAMDC2	MAM domain containing 2. (758 aa)
	CHST12	Carbohydrate sulfotransferase. (419 aa)
	ENSGAGP00000030651	Lysozyme g. (186 aa)
	GNS	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. (540 aa)
	HYAL2	Hyaluronidase. (419 aa)
	ENSGAGP00000033477	Sulfotransferase; Belongs to the sulfotransferase 1 family. (411 aa)
	EGFLAM	EGF like, fibronectin type III and laminin G domains. (1027 aa)
	ENSGAGP00000036449	Lysozyme g. (208 aa)

Your Current Organism:

Gopherus agassizii

NCBI taxonomy Id: 38772
Other names: G. agassizii, Gopherus agassizi, Gopherus polyphemus agassizii, USNM 7888, desert tortoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARSK	ENSGAGP00000015183	ENSGAGP00000011740	ENSGAGP00000015183	Arylsulfatase family member K.	Beta-hexosaminidase.	0.667
ARSK	ENSGAGP00000022164	ENSGAGP00000011740	ENSGAGP00000022164	Arylsulfatase family member K.	Sulfatase domain-containing protein.	0.420
ARSK	HEXB	ENSGAGP00000011740	ENSGAGP00000016500	Arylsulfatase family member K.	Beta-hexosaminidase.	0.724
ARSK	IDUA	ENSGAGP00000011740	ENSGAGP00000014219	Arylsulfatase family member K.	Iduronidase alpha-L-.	0.814
ARSK	SGSH	ENSGAGP00000011740	ENSGAGP00000012795	Arylsulfatase family member K.	N-sulfoglucosamine sulfohydrolase.	0.516
B3GALT6	B3GAT3	ENSGAGP00000002384	ENSGAGP00000022863	Hexosyltransferase.	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.	0.912
B3GALT6	B4GALT4	ENSGAGP00000002384	ENSGAGP00000008496	Hexosyltransferase.	Beta-1,4-galactosyltransferase 4.	0.526
B3GALT6	DCN	ENSGAGP00000002384	ENSGAGP00000022136	Hexosyltransferase.	Decorin; May affect the rate of fibrils formation.	0.648
B3GALT6	ENSGAGP00000015183	ENSGAGP00000002384	ENSGAGP00000015183	Hexosyltransferase.	Beta-hexosaminidase.	0.506
B3GALT6	ENSGAGP00000019942	ENSGAGP00000002384	ENSGAGP00000019942	Hexosyltransferase.	DUF4962 domain-containing protein.	0.553
B3GALT6	EXT2	ENSGAGP00000002384	ENSGAGP00000020673	Hexosyltransferase.	Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family.	0.404
B3GALT6	HEXB	ENSGAGP00000002384	ENSGAGP00000016500	Hexosyltransferase.	Beta-hexosaminidase.	0.506
B3GALT6	XYLT1	ENSGAGP00000002384	ENSGAGP00000028962	Hexosyltransferase.	Xylosyltransferase 1.	0.486
B3GALT6	XYLT2	ENSGAGP00000002384	ENSGAGP00000019316	Hexosyltransferase.	Xylosyltransferase 2.	0.486
B3GAT3	B3GALT6	ENSGAGP00000022863	ENSGAGP00000002384	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.	Hexosyltransferase.	0.912
B3GAT3	B4GALT4	ENSGAGP00000022863	ENSGAGP00000008496	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.	Beta-1,4-galactosyltransferase 4.	0.514
B3GAT3	CHST11	ENSGAGP00000022863	ENSGAGP00000009081	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.	Carbohydrate sulfotransferase.	0.498
B3GAT3	CHST12	ENSGAGP00000022863	ENSGAGP00000030563	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.	Carbohydrate sulfotransferase.	0.538
B3GAT3	CHST13	ENSGAGP00000022863	ENSGAGP00000002673	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.	Carbohydrate sulfotransferase.	0.556
B3GAT3	CHST14	ENSGAGP00000022863	ENSGAGP00000024693	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.	Carbohydrate sulfotransferase.	0.551