(16 nodes) Macrophage differentiation network (Gopherus agassizii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (500 aa)
	VEGFA	Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (238 aa)
	EIF2AK1	Eukaryotic translation initiation factor 2 alpha kinase 1. (649 aa)
	ENSGAGP00000003720	Deacetylase sirtuin-type domain-containing protein. (742 aa)
	NKX2-3	NK2 homeobox 3. (323 aa)
	TSPAN2	Tetraspanin 2; Belongs to the tetraspanin (TM4SF) family. (223 aa)
	GAB3	GRB2 associated binding protein 3. (598 aa)
	APP	Amyloid beta precursor protein. (748 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (169 aa)
	ENSGAGP00000026930	Uncharacterized protein; Belongs to the peptidase C14A family. (483 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (541 aa)
	NRROS	Negative regulator of reactive oxygen species. (709 aa)
	ENSGAGP00000030020	Uncharacterized protein. (719 aa)
	ENSGAGP00000030126	Uncharacterized protein. (481 aa)
	CEBPA	CCAAT/enhancer-binding protein. (324 aa)
	ENSGAGP00000033480	Interleukin; Belongs to the IL-15/IL-21 family. (179 aa)

Your Current Organism:

Gopherus agassizii

NCBI taxonomy Id: 38772
Other names: G. agassizii, Gopherus agassizi, Gopherus polyphemus agassizii, USNM 7888, desert tortoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	ENSGAGP00000030126	ENSGAGP00000022710	ENSGAGP00000030126	Amyloid beta precursor protein.	Uncharacterized protein.	0.483
CASP10	CASP8	ENSGAGP00000026939	ENSGAGP00000034705	Caspase 10; Belongs to the peptidase C14A family.	Caspase 8; Belongs to the peptidase C14A family.	0.727
CASP8	CASP10	ENSGAGP00000034705	ENSGAGP00000026939	Caspase 8; Belongs to the peptidase C14A family.	Caspase 10; Belongs to the peptidase C14A family.	0.727
CASP8	ENSGAGP00000026930	ENSGAGP00000034705	ENSGAGP00000026930	Caspase 8; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.776
CEBPA	ENSGAGP00000003720	ENSGAGP00000032656	ENSGAGP00000003720	CCAAT/enhancer-binding protein.	Deacetylase sirtuin-type domain-containing protein.	0.405
ENSGAGP00000003720	CEBPA	ENSGAGP00000003720	ENSGAGP00000032656	Deacetylase sirtuin-type domain-containing protein.	CCAAT/enhancer-binding protein.	0.405
ENSGAGP00000003720	ENSGAGP00000030126	ENSGAGP00000003720	ENSGAGP00000030126	Deacetylase sirtuin-type domain-containing protein.	Uncharacterized protein.	0.418
ENSGAGP00000003720	IFNG	ENSGAGP00000003720	ENSGAGP00000026465	Deacetylase sirtuin-type domain-containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.438
ENSGAGP00000026930	CASP8	ENSGAGP00000026930	ENSGAGP00000034705	Uncharacterized protein; Belongs to the peptidase C14A family.	Caspase 8; Belongs to the peptidase C14A family.	0.776
ENSGAGP00000030020	ENSGAGP00000030126	ENSGAGP00000030020	ENSGAGP00000030126	Uncharacterized protein.	Uncharacterized protein.	0.603
ENSGAGP00000030020	GAB3	ENSGAGP00000030020	ENSGAGP00000015374	Uncharacterized protein.	GRB2 associated binding protein 3.	0.451
ENSGAGP00000030020	IFNG	ENSGAGP00000030020	ENSGAGP00000026465	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.459
ENSGAGP00000030126	APP	ENSGAGP00000030126	ENSGAGP00000022710	Uncharacterized protein.	Amyloid beta precursor protein.	0.483
ENSGAGP00000030126	ENSGAGP00000003720	ENSGAGP00000030126	ENSGAGP00000003720	Uncharacterized protein.	Deacetylase sirtuin-type domain-containing protein.	0.418
ENSGAGP00000030126	ENSGAGP00000030020	ENSGAGP00000030126	ENSGAGP00000030020	Uncharacterized protein.	Uncharacterized protein.	0.603
ENSGAGP00000030126	ENSGAGP00000033480	ENSGAGP00000030126	ENSGAGP00000033480	Uncharacterized protein.	Interleukin; Belongs to the IL-15/IL-21 family.	0.694
ENSGAGP00000030126	IFNG	ENSGAGP00000030126	ENSGAGP00000026465	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.673
ENSGAGP00000033480	ENSGAGP00000030126	ENSGAGP00000033480	ENSGAGP00000030126	Interleukin; Belongs to the IL-15/IL-21 family.	Uncharacterized protein.	0.694
ENSGAGP00000033480	IFNG	ENSGAGP00000033480	ENSGAGP00000026465	Interleukin; Belongs to the IL-15/IL-21 family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.894
GAB3	ENSGAGP00000030020	ENSGAGP00000015374	ENSGAGP00000030020	GRB2 associated binding protein 3.	Uncharacterized protein.	0.451