(17 nodes) Retrograde protein transport, ER to cytosol network (Gopherus agassizii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSGAGP00000019948	Uncharacterized protein. (89 aa)
	DERL2	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
	ENSGAGP00000012688	Uncharacterized protein. (253 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (761 aa)
	ENSGAGP00000015915	Uncharacterized protein; Belongs to the AAA ATPase family. (766 aa)
	SEC61B	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
	ENSGAGP00000007216	Uncharacterized protein. (123 aa)
	SEL1L	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (748 aa)
	HSP90B1	Heat shock protein 90 beta family member 1. (824 aa)
	DERL3	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
	HERPUD1	Homocysteine inducible ER protein with ubiquitin like domain 1. (382 aa)
	FAF2	Fas associated factor family member 2. (359 aa)
	AUP1	AUP1 lipid droplet regulating VLDL assembly factor. (433 aa)
	HM13	Histocompatibility minor 13. (306 aa)
	UFD1	Ubiquitin recognition factor in ER associated degradation 1. (307 aa)
	RHBDD1	Rhomboid domain containing 1. (314 aa)
	DERL1	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (206 aa)

Your Current Organism:

Gopherus agassizii

NCBI taxonomy Id: 38772
Other names: G. agassizii, Gopherus agassizi, Gopherus polyphemus agassizii, USNM 7888, desert tortoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AUP1	DERL2	ENSGAGP00000006631	ENSGAGP00000018161	AUP1 lipid droplet regulating VLDL assembly factor.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.459
AUP1	DERL3	ENSGAGP00000006631	ENSGAGP00000036528	AUP1 lipid droplet regulating VLDL assembly factor.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.459
AUP1	ENSGAGP00000015915	ENSGAGP00000006631	ENSGAGP00000015915	AUP1 lipid droplet regulating VLDL assembly factor.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.580
AUP1	FAF2	ENSGAGP00000006631	ENSGAGP00000000693	AUP1 lipid droplet regulating VLDL assembly factor.	Fas associated factor family member 2.	0.678
AUP1	SEL1L	ENSGAGP00000006631	ENSGAGP00000007213	AUP1 lipid droplet regulating VLDL assembly factor.	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase.	0.893
AUP1	VCP	ENSGAGP00000006631	ENSGAGP00000015364	AUP1 lipid droplet regulating VLDL assembly factor.	Valosin containing protein; Belongs to the AAA ATPase family.	0.664
DERL1	DERL2	ENSGAGP00000024467	ENSGAGP00000018161	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.973
DERL1	DERL3	ENSGAGP00000024467	ENSGAGP00000036528	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.973
DERL1	ENSGAGP00000007216	ENSGAGP00000024467	ENSGAGP00000007216	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Uncharacterized protein.	0.536
DERL1	ENSGAGP00000012688	ENSGAGP00000024467	ENSGAGP00000012688	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Uncharacterized protein.	0.955
DERL1	ENSGAGP00000015915	ENSGAGP00000024467	ENSGAGP00000015915	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.977
DERL1	FAF2	ENSGAGP00000024467	ENSGAGP00000000693	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Fas associated factor family member 2.	0.832
DERL1	HERPUD1	ENSGAGP00000024467	ENSGAGP00000032566	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Homocysteine inducible ER protein with ubiquitin like domain 1.	0.400
DERL1	HM13	ENSGAGP00000024467	ENSGAGP00000028748	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Histocompatibility minor 13.	0.848
DERL1	HSP90B1	ENSGAGP00000024467	ENSGAGP00000007172	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Heat shock protein 90 beta family member 1.	0.536
DERL1	SEL1L	ENSGAGP00000024467	ENSGAGP00000007213	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase.	0.986
DERL1	UFD1	ENSGAGP00000024467	ENSGAGP00000028620	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Ubiquitin recognition factor in ER associated degradation 1.	0.985
DERL1	VCP	ENSGAGP00000024467	ENSGAGP00000015364	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Valosin containing protein; Belongs to the AAA ATPase family.	0.995
DERL2	AUP1	ENSGAGP00000018161	ENSGAGP00000006631	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	AUP1 lipid droplet regulating VLDL assembly factor.	0.459
DERL2	DERL1	ENSGAGP00000018161	ENSGAGP00000024467	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.973