(38 nodes) Heterochromatin assembly network (Gopherus agassizii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RRP8	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (423 aa)
	LMNB1	Lamin B1; Belongs to the intermediate filament family. (587 aa)
	BEND3	BEN domain containing 3. (836 aa)
	SPTY2D1	SPT2 chromatin protein domain containing 1. (643 aa)
	HAT1	Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (542 aa)
	ENSGAGP00000031781	Arb2 domain-containing protein. (350 aa)
	ENSGAGP00000030641	Uncharacterized protein. (69 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (663 aa)
	ENSGAGP00000027797	Uncharacterized protein; Belongs to the intermediate filament family. (592 aa)
	BAHD1	Bromo adjacent homology domain containing 1. (829 aa)
	ENSGAGP00000023611	Uncharacterized protein. (93 aa)
	EZH1	Enhancer of zeste 1 polycomb repressive complex 2 subunit. (751 aa)
	ENSGAGP00000022670	PHD-type domain-containing protein. (274 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (747 aa)
	RIF1	Replication timing regulatory factor 1. (2365 aa)
	RB1	RB transcriptional corepressor 1. (923 aa)
	ENSGAGP00000014163	H15 domain-containing protein. (198 aa)
	ENSGAGP00000014157	H15 domain-containing protein. (219 aa)
	ENSGAGP00000013462	Uncharacterized protein. (96 aa)
	HELLS	Helicase, lymphoid specific. (701 aa)
	ENSGAGP00000012318	Uncharacterized protein. (131 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1390 aa)
	ENSGAGP00000008338	Uncharacterized protein. (874 aa)
	SIRT6	Sirtuin 6. (333 aa)
	LMNB2	Lamin B2; Belongs to the intermediate filament family. (601 aa)
	MBD2	Methyl-CpG binding domain protein 2. (212 aa)
	ENSGAGP00000001249	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (211 aa)
	ENSGAGP00000001518	MBD domain-containing protein. (287 aa)
	ZNFX1	Zinc finger NFX1-type containing 1. (1915 aa)
	ENSGAGP00000003479	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1064 aa)
	ENSGAGP00000003720	Deacetylase sirtuin-type domain-containing protein. (742 aa)
	ENSGAGP00000004083	GFA domain-containing protein. (227 aa)
	DOT1L	Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1496 aa)
	PPM1D	Protein phosphatase, Mg2+/Mn2+ dependent 1D. (601 aa)
	SMCHD1	Structural maintenance of chromosomes flexible hinge domain containing 1. (1800 aa)
	FAM172A	Family with sequence similarity 172 member A. (416 aa)
	MECP2	Methyl-CpG binding protein 2. (459 aa)
	ENSGAGP00000006370	CBFD_NFYB_HMF domain-containing protein. (142 aa)

Your Current Organism:

Gopherus agassizii

NCBI taxonomy Id: 38772
Other names: G. agassizii, Gopherus agassizi, Gopherus polyphemus agassizii, USNM 7888, desert tortoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAHD1	EZH2	ENSGAGP00000024683	ENSGAGP00000020898	Bromo adjacent homology domain containing 1.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.490
DNMT1	ENSGAGP00000001518	ENSGAGP00000012312	ENSGAGP00000001518	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	MBD domain-containing protein.	0.549
DNMT1	ENSGAGP00000003720	ENSGAGP00000012312	ENSGAGP00000003720	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Deacetylase sirtuin-type domain-containing protein.	0.563
DNMT1	ENSGAGP00000013462	ENSGAGP00000012312	ENSGAGP00000013462	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Uncharacterized protein.	0.401
DNMT1	ENSGAGP00000022670	ENSGAGP00000012312	ENSGAGP00000022670	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	PHD-type domain-containing protein.	0.502
DNMT1	EZH1	ENSGAGP00000012312	ENSGAGP00000022835	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	0.896
DNMT1	EZH2	ENSGAGP00000012312	ENSGAGP00000020898	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.896
DNMT1	HELLS	ENSGAGP00000012312	ENSGAGP00000013456	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Helicase, lymphoid specific.	0.401
DNMT1	MBD2	ENSGAGP00000012312	ENSGAGP00000001052	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Methyl-CpG binding domain protein 2.	0.549
DNMT1	MECP2	ENSGAGP00000012312	ENSGAGP00000005808	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Methyl-CpG binding protein 2.	0.651
DNMT1	RB1	ENSGAGP00000012312	ENSGAGP00000016309	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	RB transcriptional corepressor 1.	0.444
DOT1L	ENSGAGP00000003720	ENSGAGP00000004266	ENSGAGP00000003720	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	Deacetylase sirtuin-type domain-containing protein.	0.681
DOT1L	EZH1	ENSGAGP00000004266	ENSGAGP00000022835	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	0.888
DOT1L	EZH2	ENSGAGP00000004266	ENSGAGP00000020898	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.888
DOT1L	SIRT6	ENSGAGP00000004266	ENSGAGP00000008021	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	Sirtuin 6.	0.454
ENSGAGP00000001249	ENSGAGP00000003479	ENSGAGP00000001249	ENSGAGP00000003479	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	0.899
ENSGAGP00000001518	DNMT1	ENSGAGP00000001518	ENSGAGP00000012312	MBD domain-containing protein.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.549
ENSGAGP00000001518	ENSGAGP00000012318	ENSGAGP00000001518	ENSGAGP00000012318	MBD domain-containing protein.	Uncharacterized protein.	0.549
ENSGAGP00000001518	ENSGAGP00000013462	ENSGAGP00000001518	ENSGAGP00000013462	MBD domain-containing protein.	Uncharacterized protein.	0.508
ENSGAGP00000001518	HELLS	ENSGAGP00000001518	ENSGAGP00000013456	MBD domain-containing protein.	Helicase, lymphoid specific.	0.508