(77 nodes) Catalytic step 2 spliceosome network (Gopherus agassizii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CACTIN	Cactin, spliceosome C complex subunit. (705 aa)
	PPIL1	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (166 aa)
	SF3A1	Splicing factor 3a subunit 1. (758 aa)
	SNRPB	Small nuclear ribonucleoprotein-associated protein. (240 aa)
	LSM7	LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (223 aa)
	PPIE	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (244 aa)
	ENSGAGP00000002479	Uncharacterized protein. (89 aa)
	ENSGAGP00000004271	Uncharacterized protein. (54 aa)
	PNN	Pinin, desmosome associated protein. (692 aa)
	HNRNPR	Heterogeneous nuclear ribonucleoprotein R. (643 aa)
	ENSGAGP00000007514	RRM domain-containing protein. (394 aa)
	SF3B3	Splicing factor 3b subunit 3. (1206 aa)
	CDC40	Cell division cycle 40. (524 aa)
	SNRPG	Small nuclear ribonucleoprotein G. (76 aa)
	DDX23	DEAD-box helicase 23. (813 aa)
	ZCCHC8	Zinc finger CCHC-type containing 8. (719 aa)
	TFIP11	Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Belongs to the TFP11/STIP family. (827 aa)
	SLU7	SLU7 homolog, splicing factor. (626 aa)
	PRPF8	Pre-mRNA processing factor 8. (2335 aa)
	SF3A2	Splicing factor 3a subunit 2. (270 aa)
	ENSGAGP00000011024	Uncharacterized protein. (148 aa)
	PRPF6	Pre-mRNA processing factor 6. (977 aa)
	SRRM1	Serine and arginine repetitive matrix 1. (907 aa)
	SNRPA1	Small nuclear ribonucleoprotein polypeptide A. (255 aa)
	SNW1	SNW domain containing 1. (536 aa)
	GPATCH1	G-patch domain containing 1. (934 aa)
	WDR83	WD repeat domain 83. (430 aa)
	ENSGAGP00000013720	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (161 aa)
	SYF2	SYF2 pre-mRNA splicing factor. (248 aa)
	ENSGAGP00000014719	Sm domain-containing protein. (57 aa)
	SNRPD1	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family. (119 aa)
	SF3B6	Splicing factor 3b subunit 6. (125 aa)
	LSM2	U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa)
	ENSGAGP00000017405	Sm domain-containing protein. (109 aa)
	PRPF19	Pre-mRNA processing factor 19. (521 aa)
	CWC22	CWC22 spliceosome associated protein homolog. (902 aa)
	SYNCRIP	Synaptotagmin binding cytoplasmic RNA interacting protein. (562 aa)
	WDR25	WD repeat domain 25. (535 aa)
	ENSGAGP00000019106	Sm domain-containing protein. (83 aa)
	ENSGAGP00000020105	Sm domain-containing protein. (59 aa)
	SF3A3	Splicing factor 3a subunit 3. (501 aa)
	ESS2	Ess-2 splicing factor homolog. (487 aa)
	DHX38	DEAH-box helicase 38. (1237 aa)
	CWC27	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (171 aa)
	DHX35	DEAH-box helicase 35. (703 aa)
	PRPF4B	Pre-mRNA processing factor 4B. (1005 aa)
	EIF4A3	Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. (406 aa)
	SF3B1	Splicing factor 3b subunit 1. (1328 aa)
	SNRPD2	Small nuclear ribonucleoprotein Sm D2. (144 aa)
	DDX41	DEAD-box helicase 41. (577 aa)
	SNRNP200	Small nuclear ribonucleoprotein U5 subunit 200. (2056 aa)
	ENSGAGP00000026203	Uncharacterized protein. (618 aa)
	SNRNP40	Small nuclear ribonucleoprotein U5 subunit 40. (358 aa)
	AQR	Aquarius intron-binding spliceosomal factor. (1460 aa)
	MTREX	Mtr4 exosome RNA helicase. (1034 aa)
	C19orf54	Chromosome 19 open reading frame 54. (322 aa)
	PPWD1	Peptidylprolyl isomerase domain and WD repeat containing 1. (631 aa)
	PPIL2	Peptidylprolyl isomerase like 2. (551 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (602 aa)
	ENSGAGP00000028961	Sm domain-containing protein. (119 aa)
	BCAS2	BCAS2 pre-mRNA processing factor. (225 aa)
	CRNKL1	Crooked neck pre-mRNA splicing factor 1. (653 aa)
	ENSGAGP00000029437	Uncharacterized protein. (286 aa)
	XAB2	XPA binding protein 2. (886 aa)
	BUD31	BUD31 homolog. (144 aa)
	MAGOH	Mago homolog, exon junction complex subunit. (146 aa)
	SART1	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (814 aa)
	ENSGAGP00000032079	Sm domain-containing protein. (85 aa)
	SNRPD3	Small nuclear ribonucleoprotein Sm D3. (126 aa)
	PLRG1	Pleiotropic regulator 1. (516 aa)
	RBM8A	RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (174 aa)
	SF3B2	Splicing factor 3b subunit 2. (859 aa)
	CWC15	CWC15 spliceosome associated protein homolog. (233 aa)
	RBM22	RNA binding motif protein 22. (420 aa)
	DHX8	DEAH-box helicase 8. (1192 aa)
	ENSGAGP00000035189	Uncharacterized protein. (257 aa)
	LSM3	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (102 aa)

Your Current Organism:

Gopherus agassizii

NCBI taxonomy Id: 38772
Other names: G. agassizii, Gopherus agassizi, Gopherus polyphemus agassizii, USNM 7888, desert tortoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQR	BCAS2	ENSGAGP00000026888	ENSGAGP00000029225	Aquarius intron-binding spliceosomal factor.	BCAS2 pre-mRNA processing factor.	0.982
AQR	BUD31	ENSGAGP00000026888	ENSGAGP00000030291	Aquarius intron-binding spliceosomal factor.	BUD31 homolog.	0.999
AQR	CACTIN	ENSGAGP00000026888	ENSGAGP00000000650	Aquarius intron-binding spliceosomal factor.	Cactin, spliceosome C complex subunit.	0.742
AQR	CDC40	ENSGAGP00000026888	ENSGAGP00000008706	Aquarius intron-binding spliceosomal factor.	Cell division cycle 40.	0.991
AQR	CRNKL1	ENSGAGP00000026888	ENSGAGP00000029374	Aquarius intron-binding spliceosomal factor.	Crooked neck pre-mRNA splicing factor 1.	0.999
AQR	CWC15	ENSGAGP00000026888	ENSGAGP00000033728	Aquarius intron-binding spliceosomal factor.	CWC15 spliceosome associated protein homolog.	0.980
AQR	CWC22	ENSGAGP00000026888	ENSGAGP00000018188	Aquarius intron-binding spliceosomal factor.	CWC22 spliceosome associated protein homolog.	0.953
AQR	CWC27	ENSGAGP00000026888	ENSGAGP00000021336	Aquarius intron-binding spliceosomal factor.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.855
AQR	DDX23	ENSGAGP00000026888	ENSGAGP00000009900	Aquarius intron-binding spliceosomal factor.	DEAD-box helicase 23.	0.564
AQR	DHX35	ENSGAGP00000026888	ENSGAGP00000021411	Aquarius intron-binding spliceosomal factor.	DEAH-box helicase 35.	0.767
AQR	DHX38	ENSGAGP00000026888	ENSGAGP00000021242	Aquarius intron-binding spliceosomal factor.	DEAH-box helicase 38.	0.765
AQR	DHX8	ENSGAGP00000026888	ENSGAGP00000034241	Aquarius intron-binding spliceosomal factor.	DEAH-box helicase 8.	0.982
AQR	EIF4A3	ENSGAGP00000026888	ENSGAGP00000022396	Aquarius intron-binding spliceosomal factor.	Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family.	0.979
AQR	ENSGAGP00000004271	ENSGAGP00000026888	ENSGAGP00000004271	Aquarius intron-binding spliceosomal factor.	Uncharacterized protein.	0.726
AQR	ENSGAGP00000013720	ENSGAGP00000026888	ENSGAGP00000013720	Aquarius intron-binding spliceosomal factor.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.731
AQR	ENSGAGP00000014719	ENSGAGP00000026888	ENSGAGP00000014719	Aquarius intron-binding spliceosomal factor.	Sm domain-containing protein.	0.792
AQR	ENSGAGP00000017405	ENSGAGP00000026888	ENSGAGP00000017405	Aquarius intron-binding spliceosomal factor.	Sm domain-containing protein.	0.792
AQR	ENSGAGP00000019106	ENSGAGP00000026888	ENSGAGP00000019106	Aquarius intron-binding spliceosomal factor.	Sm domain-containing protein.	0.792
AQR	ENSGAGP00000020105	ENSGAGP00000026888	ENSGAGP00000020105	Aquarius intron-binding spliceosomal factor.	Sm domain-containing protein.	0.792
AQR	ENSGAGP00000028961	ENSGAGP00000026888	ENSGAGP00000028961	Aquarius intron-binding spliceosomal factor.	Sm domain-containing protein.	0.792