(20 nodes) CARD domain network (Gopherus agassizii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSGAGP00000010489	Uncharacterized protein; Belongs to the peptidase C14A family. (380 aa)
	CARD14	Caspase recruitment domain family member 14. (864 aa)
	CARD10	Caspase recruitment domain family member 10. (967 aa)
	ENSGAGP00000016992	Uncharacterized protein. (173 aa)
	ENSGAGP00000016995	Uncharacterized protein. (330 aa)
	ENSGAGP00000018924	Uncharacterized protein. (457 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (562 aa)
	ENSGAGP00000019795	Uncharacterized protein. (611 aa)
	ENSGAGP00000021520	Uncharacterized protein. (174 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1251 aa)
	ENSGAGP00000022945	Uncharacterized protein. (553 aa)
	ENSGAGP00000023224	CARD domain-containing protein. (116 aa)
	ENSGAGP00000023734	CARD domain-containing protein. (239 aa)
	ENSGAGP00000025909	CARD domain-containing protein. (239 aa)
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (428 aa)
	ENSGAGP00000028876	Uncharacterized protein. (401 aa)
	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (423 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (951 aa)
	CARD9	Caspase recruitment domain family member 9. (562 aa)

Your Current Organism:

Gopherus agassizii

NCBI taxonomy Id: 38772
Other names: G. agassizii, Gopherus agassizi, Gopherus polyphemus agassizii, USNM 7888, desert tortoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	CASP2	ENSGAGP00000022750	ENSGAGP00000027404	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 2; Belongs to the peptidase C14A family.	0.981
APAF1	CASP9	ENSGAGP00000022750	ENSGAGP00000009292	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.997
APAF1	ENSGAGP00000010489	ENSGAGP00000022750	ENSGAGP00000010489	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.945
APAF1	ENSGAGP00000019795	ENSGAGP00000022750	ENSGAGP00000019795	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.801
APAF1	ENSGAGP00000028876	ENSGAGP00000022750	ENSGAGP00000028876	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.942
APAF1	NOD1	ENSGAGP00000022750	ENSGAGP00000008131	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Nucleotide binding oligomerization domain containing 1.	0.567
CARD10	CARD14	ENSGAGP00000014416	ENSGAGP00000012792	Caspase recruitment domain family member 10.	Caspase recruitment domain family member 14.	0.847
CARD10	ENSGAGP00000023734	ENSGAGP00000014416	ENSGAGP00000023734	Caspase recruitment domain family member 10.	CARD domain-containing protein.	0.906
CARD14	CARD10	ENSGAGP00000012792	ENSGAGP00000014416	Caspase recruitment domain family member 14.	Caspase recruitment domain family member 10.	0.847
CARD14	ENSGAGP00000022945	ENSGAGP00000012792	ENSGAGP00000022945	Caspase recruitment domain family member 14.	Uncharacterized protein.	0.475
CARD14	ENSGAGP00000023734	ENSGAGP00000012792	ENSGAGP00000023734	Caspase recruitment domain family member 14.	CARD domain-containing protein.	0.903
CARD14	RIPK2	ENSGAGP00000012792	ENSGAGP00000019235	Caspase recruitment domain family member 14.	Receptor interacting serine/threonine kinase 2.	0.475
CARD9	CASP2	ENSGAGP00000001521	ENSGAGP00000027404	Caspase recruitment domain family member 9.	Caspase 2; Belongs to the peptidase C14A family.	0.531
CARD9	CASP9	ENSGAGP00000001521	ENSGAGP00000009292	Caspase recruitment domain family member 9.	Caspase 9; Belongs to the peptidase C14A family.	0.542
CARD9	ENSGAGP00000010489	ENSGAGP00000001521	ENSGAGP00000010489	Caspase recruitment domain family member 9.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.694
CARD9	ENSGAGP00000022945	ENSGAGP00000001521	ENSGAGP00000022945	Caspase recruitment domain family member 9.	Uncharacterized protein.	0.845
CARD9	ENSGAGP00000023734	ENSGAGP00000001521	ENSGAGP00000023734	Caspase recruitment domain family member 9.	CARD domain-containing protein.	0.980
CARD9	ENSGAGP00000028876	ENSGAGP00000001521	ENSGAGP00000028876	Caspase recruitment domain family member 9.	Uncharacterized protein.	0.515
CARD9	NOD1	ENSGAGP00000001521	ENSGAGP00000008131	Caspase recruitment domain family member 9.	Nucleotide binding oligomerization domain containing 1.	0.678
CARD9	RIPK2	ENSGAGP00000001521	ENSGAGP00000019235	Caspase recruitment domain family member 9.	Receptor interacting serine/threonine kinase 2.	0.855