(35 nodes) Glycosaminoglycan degradation network (Gopherus agassizii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSGAGP00000022164	Sulfatase domain-containing protein. (525 aa)
	NAGLU	N-acetyl-alpha-glucosaminidase. (620 aa)
	ENSGAGP00000023438	Beta-galactosidase. (636 aa)
	SULF1	Sulfatase 1. (1121 aa)
	HYAL3	Hyaluronidase. (508 aa)
	ENSGAGP00000017857	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. (504 aa)
	HEXB	Beta-hexosaminidase. (539 aa)
	ENSGAGP00000015183	Beta-hexosaminidase. (506 aa)
	GUSB	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (480 aa)
	IDUA	Iduronidase alpha-L-. (626 aa)
	GALNS	Galactosamine (N-acetyl)-6-sulfatase. (483 aa)
	HPSE2	Heparanase 2 (inactive). (614 aa)
	SGSH	N-sulfoglucosamine sulfohydrolase. (415 aa)
	ARSK	Arylsulfatase family member K. (578 aa)
	HYAL4	Hyaluronidase. (500 aa)
	FAM149A	Family with sequence similarity 149 member A. (620 aa)
	ENSGAGP00000007738	Hyaluronidase. (380 aa)
	GLB1L	Galactosidase beta 1 like. (640 aa)
	ENSGAGP00000005873	Uncharacterized protein. (256 aa)
	ENSGAGP00000005867	Uncharacterized protein. (332 aa)
	GET4	Guided entry of tail-anchored proteins factor 4. (330 aa)
	ARSI	Arylsulfatase family member I. (573 aa)
	FAM149B1	Family with sequence similarity 149 member B1. (527 aa)
	SULF2	Sulfatase 2. (817 aa)
	ENSGAGP00000000813	Uncharacterized protein. (186 aa)
	ARSB	Arylsulfatase B. (522 aa)
	HYAL2	Hyaluronidase. (419 aa)
	GNS	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. (540 aa)
	ARSJ	Arylsulfatase family member J. (590 aa)
	RABGGTB	Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX. (289 aa)
	BOD1L1	Biorientation of chromosomes in cell division 1 like 1. (2970 aa)
	ENSGAGP00000019898	Hyaluronidase. (562 aa)
	HPSE	Heparanase. (526 aa)
	GLB1	Beta-galactosidase. (658 aa)
	HYAL1	Hyaluronidase. (443 aa)

Your Current Organism:

Gopherus agassizii

NCBI taxonomy Id: 38772
Other names: G. agassizii, Gopherus agassizi, Gopherus polyphemus agassizii, USNM 7888, desert tortoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARSB	ARSK	ENSGAGP00000000019	ENSGAGP00000011740	Arylsulfatase B.	Arylsulfatase family member K.	0.745
ARSB	BOD1L1	ENSGAGP00000000019	ENSGAGP00000023460	Arylsulfatase B.	Biorientation of chromosomes in cell division 1 like 1.	0.525
ARSB	ENSGAGP00000000813	ENSGAGP00000000019	ENSGAGP00000000813	Arylsulfatase B.	Uncharacterized protein.	0.525
ARSB	ENSGAGP00000005867	ENSGAGP00000000019	ENSGAGP00000005867	Arylsulfatase B.	Uncharacterized protein.	0.617
ARSB	ENSGAGP00000005873	ENSGAGP00000000019	ENSGAGP00000005873	Arylsulfatase B.	Uncharacterized protein.	0.617
ARSB	ENSGAGP00000007738	ENSGAGP00000000019	ENSGAGP00000007738	Arylsulfatase B.	Hyaluronidase.	0.809
ARSB	ENSGAGP00000015183	ENSGAGP00000000019	ENSGAGP00000015183	Arylsulfatase B.	Beta-hexosaminidase.	0.526
ARSB	ENSGAGP00000017857	ENSGAGP00000000019	ENSGAGP00000017857	Arylsulfatase B.	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family.	0.494
ARSB	ENSGAGP00000019898	ENSGAGP00000000019	ENSGAGP00000019898	Arylsulfatase B.	Hyaluronidase.	0.813
ARSB	ENSGAGP00000022164	ENSGAGP00000000019	ENSGAGP00000022164	Arylsulfatase B.	Sulfatase domain-containing protein.	0.400
ARSB	ENSGAGP00000023438	ENSGAGP00000000019	ENSGAGP00000023438	Arylsulfatase B.	Beta-galactosidase.	0.525
ARSB	FAM149A	ENSGAGP00000000019	ENSGAGP00000009638	Arylsulfatase B.	Family with sequence similarity 149 member A.	0.473
ARSB	FAM149B1	ENSGAGP00000000019	ENSGAGP00000002273	Arylsulfatase B.	Family with sequence similarity 149 member B1.	0.473
ARSB	GLB1	ENSGAGP00000000019	ENSGAGP00000021387	Arylsulfatase B.	Beta-galactosidase.	0.551
ARSB	GLB1L	ENSGAGP00000000019	ENSGAGP00000007257	Arylsulfatase B.	Galactosidase beta 1 like.	0.551
ARSB	GNS	ENSGAGP00000000019	ENSGAGP00000032110	Arylsulfatase B.	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family.	0.498
ARSB	GUSB	ENSGAGP00000000019	ENSGAGP00000015146	Arylsulfatase B.	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.	0.726
ARSB	HEXB	ENSGAGP00000000019	ENSGAGP00000016500	Arylsulfatase B.	Beta-hexosaminidase.	0.536
ARSB	HYAL1	ENSGAGP00000000019	ENSGAGP00000021653	Arylsulfatase B.	Hyaluronidase.	0.768
ARSB	HYAL2	ENSGAGP00000000019	ENSGAGP00000033250	Arylsulfatase B.	Hyaluronidase.	0.811