STRINGSTRING
ENSGAGP00000029685 ENSGAGP00000029685 CCNG2 CCNG2 IGF1R IGF1R BNIP3 BNIP3 IL7R IL7R STK11 STK11 IGF1 IGF1 PIK3R1 PIK3R1 BRAF BRAF CDKN1A CDKN1A GADD45G GADD45G GABARAPL2 GABARAPL2 LDLRAD4 LDLRAD4 ENSGAGP00000033365 ENSGAGP00000033365 FOXO1 FOXO1 TSSK3 TSSK3 TGFBR2 TGFBR2 S1PR1 S1PR1 CAT CAT SMAD3 SMAD3 MAPK8 MAPK8 SUCO SUCO FASLG FASLG ENSGAGP00000031652 ENSGAGP00000031652 ENSGAGP00000031650 ENSGAGP00000031650 RAF1 RAF1 ENSGAGP00000031386 ENSGAGP00000031386 AKT2 AKT2 ENSGAGP00000030885 ENSGAGP00000030885 ENSGAGP00000030724 ENSGAGP00000030724 ENSGAGP00000030722 ENSGAGP00000030722 RRAD RRAD PTEN PTEN G6PC3 G6PC3 SGK1 SGK1 CCNB2 CCNB2 RNF111 RNF111 INSR INSR MYO9B MYO9B PDPK1 PDPK1 AKT3 AKT3 ENSGAGP00000029318 ENSGAGP00000029318 RNF6 RNF6 SKP2 SKP2 MAPK1 MAPK1 AGAP2 AGAP2 PLK3 PLK3 ENSGAGP00000027353 ENSGAGP00000027353 G6PC2 G6PC2 ENSGAGP00000027011 ENSGAGP00000027011 CHUK CHUK FOXO4 FOXO4 TGFB1 TGFB1 RASGEF1B RASGEF1B ENSGAGP00000024577 ENSGAGP00000024577 ENSGAGP00000024557 ENSGAGP00000024557 CSDE1 CSDE1 NRAS NRAS ENSGAGP00000024017 ENSGAGP00000024017 PRKAB1 PRKAB1 PLK4 PLK4 SLC35E3 SLC35E3 IRS4 IRS4 PRKAG2 PRKAG2 ENSGAGP00000022266 ENSGAGP00000022266 SLC2A4 SLC2A4 ENSGAGP00000021878 ENSGAGP00000021878 FBXO25 FBXO25 ENSGAGP00000021179 ENSGAGP00000021179 ENSGAGP00000021177 ENSGAGP00000021177 ENSGAGP00000021175 ENSGAGP00000021175 ENSGAGP00000021093 ENSGAGP00000021093 SOS1 SOS1 ENSGAGP00000020307 ENSGAGP00000020307 ENSGAGP00000020230 ENSGAGP00000020230 PLK2 PLK2 ENSGAGP00000019592 ENSGAGP00000019592 STK4 STK4 GADD45B GADD45B GABARAPL1 GABARAPL1 FBXO32 FBXO32 TGFB2 TGFB2 ENSGAGP00000017120 ENSGAGP00000017120 SNAPIN SNAPIN ENSGAGP00000016607 ENSGAGP00000016607 TGFB3 TGFB3 PIK3CD PIK3CD MAPK9 MAPK9 ENSGAGP00000016192 ENSGAGP00000016192 ENSGAGP00000015996 ENSGAGP00000015996 ENSGAGP00000015633 ENSGAGP00000015633 CDKN1B CDKN1B CCND1 CCND1 GADD45A GADD45A SOS2 SOS2 EP300 EP300 TGFBR1 TGFBR1 ENSGAGP00000014734 ENSGAGP00000014734 ENSGAGP00000014602 ENSGAGP00000014602 KRAS KRAS IL6 IL6 IRS1 IRS1 FOXG1 FOXG1 ENSGAGP00000013787 ENSGAGP00000013787 ENSGAGP00000013677 ENSGAGP00000013677 PRKAG1 PRKAG1 ENSGAGP00000013269 ENSGAGP00000013269 IKBKB IKBKB IRS2 IRS2 CDK3 CDK3 PIK3CA PIK3CA ENSGAGP00000011982 ENSGAGP00000011982 ENSGAGP00000011981 ENSGAGP00000011981 MAPK14 MAPK14 MAPK12 MAPK12 MAPK11 MAPK11 SMAD4 SMAD4 IL10 IL10 SGK3 SGK3 PRKAA1 PRKAA1 ENSGAGP00000010364 ENSGAGP00000010364 ENSGAGP00000010339 ENSGAGP00000010339 ENSGAGP00000010337 ENSGAGP00000010337 CREBBP CREBBP ENSGAGP00000009699 ENSGAGP00000009699 RASL11B RASL11B RAG1 RAG1 RAG2 RAG2 PIK3CB PIK3CB ENSGAGP00000009032 ENSGAGP00000009032 ENSGAGP00000008575 ENSGAGP00000008575 ENSGAGP00000008401 ENSGAGP00000008401 PRMT1 PRMT1 ENSGAGP00000008157 ENSGAGP00000008157 MAPK13 MAPK13 ENSGAGP00000007472 ENSGAGP00000007472 INSRR INSRR GRB2 GRB2 ENSGAGP00000006937 ENSGAGP00000006937 TNFSF10 TNFSF10 MAPK10 MAPK10 MAP2K1 MAP2K1 ENSGAGP00000005562 ENSGAGP00000005562 USP7 USP7 EGF EGF ENSGAGP00000005130 ENSGAGP00000005130 REM2 REM2 PRMT3 PRMT3 HOMER2 HOMER2 CDK2 CDK2 ENSGAGP00000004436 ENSGAGP00000004436 CCNB1 CCNB1 ENSGAGP00000004317 ENSGAGP00000004317 RASGEF1A RASGEF1A SGK2 SGK2 NLK NLK ENSGAGP00000003851 ENSGAGP00000003851 ENSGAGP00000003796 ENSGAGP00000003796 ENSGAGP00000003720 ENSGAGP00000003720 ENSGAGP00000003677 ENSGAGP00000003677 SETD7 SETD7 PRKAA2 PRKAA2 PLK1 PLK1 ENSGAGP00000002879 ENSGAGP00000002879 PRMT8 PRMT8 CDKN2D CDKN2D ENSGAGP00000002241 ENSGAGP00000002241 ENSGAGP00000002115 ENSGAGP00000002115 MAPK3 MAPK3 REM1 REM1 ENSGAGP00000001654 ENSGAGP00000001654 BCL6 BCL6 PCK1 PCK1 ATG12 ATG12 PMEPA1 PMEPA1 RBL2 RBL2 PRKAB2 PRKAB2 ENSGAGP00000000687 ENSGAGP00000000687 GRM1 GRM1 FOXJ2 FOXJ2 HOMER1 HOMER1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSGAGP00000029685Uncharacterized protein. (218 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (299 aa)
IGF1RTyrosine-protein kinase receptor. (1251 aa)
BNIP3BCL2 interacting protein 3. (205 aa)
IL7RInterleukin 7 receptor. (461 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (440 aa)
IGF1Insulin like growth factor 1. (153 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (805 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (155 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (233 aa)
ENSGAGP00000033365Uncharacterized protein. (437 aa)
FOXO1Forkhead box O1. (650 aa)
TSSK3Testis specific serine kinase 3. (268 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (380 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (529 aa)
SMAD3Mothers against decapentaplegic homolog. (457 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
SUCOSUN domain containing ossification factor. (1160 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (242 aa)
ENSGAGP00000031652ANK_REP_REGION domain-containing protein. (93 aa)
ENSGAGP00000031650ANK_REP_REGION domain-containing protein. (142 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (667 aa)
ENSGAGP00000031386Uncharacterized protein. (463 aa)
AKT2Non-specific serine/threonine protein kinase. (673 aa)
ENSGAGP00000030885WH1 domain-containing protein. (356 aa)
ENSGAGP00000030724Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (275 aa)
ENSGAGP00000030722Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (274 aa)
RRADRRAD, Ras related glycolysis inhibitor and calcium channel regulator. (311 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
G6PC3Glucose-6-phosphatase catalytic subunit 3. (387 aa)
SGK1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (400 aa)
RNF111Ring finger protein 111. (993 aa)
INSRTyrosine-protein kinase receptor. (1325 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2217 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (555 aa)
AKT3Non-specific serine/threonine protein kinase. (524 aa)
ENSGAGP00000029318Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
RNF6Ring finger protein 6. (688 aa)
SKP2S-phase kinase associated protein 2. (427 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (419 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (786 aa)
PLK3Serine/threonine-protein kinase PLK. (667 aa)
ENSGAGP00000027353Uncharacterized protein. (189 aa)
G6PC2Glucose-6-phosphatase catalytic subunit 2. (295 aa)
ENSGAGP00000027011FOXO-TAD domain-containing protein. (455 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (785 aa)
FOXO4Forkhead box O4. (566 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
RASGEF1BRasGEF domain family member 1B. (478 aa)
ENSGAGP00000024577Fork-head domain-containing protein. (293 aa)
ENSGAGP00000024557Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2094 aa)
CSDE1Cold shock domain containing E1. (843 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ENSGAGP00000024017RanBP2-type domain-containing protein. (524 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (274 aa)
PLK4Polo like kinase 4. (993 aa)
SLC35E3Solute carrier family 35 member E3. (272 aa)
IRS4Insulin receptor substrate 4. (1174 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (336 aa)
ENSGAGP00000022266Uncharacterized protein. (117 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (475 aa)
ENSGAGP00000021878Uncharacterized protein. (217 aa)
FBXO25F-box protein 25. (370 aa)
ENSGAGP00000021179Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (364 aa)
ENSGAGP00000021177Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (361 aa)
ENSGAGP00000021175Protein kinase domain-containing protein. (328 aa)
ENSGAGP00000021093Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (580 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1306 aa)
ENSGAGP00000020307Uncharacterized protein. (348 aa)
ENSGAGP00000020230Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (385 aa)
PLK2Serine/threonine-protein kinase PLK. (668 aa)
ENSGAGP00000019592RING-type domain-containing protein. (169 aa)
STK4Serine/threonine kinase 4. (502 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (169 aa)
GABARAPL1GABA type A receptor associated protein like 1. (117 aa)
FBXO32F-box protein 32. (355 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
ENSGAGP00000017120Protein kinase domain-containing protein. (377 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (132 aa)
ENSGAGP00000016607MH2 domain-containing protein. (251 aa)
TGFB3Transforming growth factor beta 3. (456 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ENSGAGP00000016192Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (291 aa)
ENSGAGP00000015996Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (75 aa)
ENSGAGP00000015633Uncharacterized protein. (186 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (292 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (159 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1331 aa)
EP300E1A binding protein p300. (2459 aa)
TGFBR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (440 aa)
ENSGAGP00000014734Fork-head domain-containing protein. (659 aa)
ENSGAGP00000014602Uncharacterized protein. (543 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
IL6Interleukin 6. (214 aa)
IRS1Insulin receptor substrate 1. (1191 aa)
FOXG1Forkhead box G1. (463 aa)
ENSGAGP00000013787Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (226 aa)
ENSGAGP00000013677Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (158 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (286 aa)
ENSGAGP00000013269Uncharacterized protein. (184 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (754 aa)
IRS2Insulin receptor substrate 2. (1113 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (291 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSGAGP00000011982Uncharacterized protein. (358 aa)
ENSGAGP00000011981Uncharacterized protein. (238 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK12Mitogen-activated protein kinase. (361 aa)
MAPK11Mitogen-activated protein kinase. (361 aa)
SMAD4Mothers against decapentaplegic homolog. (551 aa)
IL10Interleukin 10. (177 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (490 aa)
PRKAA1Non-specific serine/threonine protein kinase. (659 aa)
ENSGAGP00000010364Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
ENSGAGP00000010339Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (352 aa)
ENSGAGP00000010337Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (351 aa)
CREBBPCREB binding protein. (2347 aa)
ENSGAGP00000009699Protein kinase domain-containing protein. (82 aa)
RASL11BRAS like family 11 member B. (248 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1049 aa)
RAG2Recombination activating 2. (526 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
ENSGAGP00000009032Uncharacterized protein. (378 aa)
ENSGAGP00000008575Uncharacterized protein. (182 aa)
ENSGAGP00000008401Uncharacterized protein. (131 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (296 aa)
ENSGAGP00000008157Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (466 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
ENSGAGP00000007472TAN domain-containing protein. (303 aa)
INSRRTyrosine-protein kinase receptor. (1153 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ENSGAGP00000006937BTB domain-containing protein. (59 aa)
TNFSF10TNF superfamily member 10; Belongs to the tumor necrosis factor family. (289 aa)
MAPK10Mitogen-activated protein kinase. (461 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (435 aa)
ENSGAGP00000005562Uncharacterized protein. (345 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1101 aa)
EGFEpidermal growth factor. (1261 aa)
ENSGAGP00000005130Protein kinase domain-containing protein. (219 aa)
REM2RRAD and GEM like GTPase 2. (258 aa)
PRMT3Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (526 aa)
HOMER2Homer scaffold protein 2. (378 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
ENSGAGP00000004436SWIB domain-containing protein. (125 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (410 aa)
ENSGAGP00000004317Endo/exonuclease/phosphatase domain-containing protein. (546 aa)
RASGEF1ARasGEF domain family member 1A. (491 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (387 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
ENSGAGP00000003851Fork-head domain-containing protein. (191 aa)
ENSGAGP00000003796Protein kinase domain-containing protein. (361 aa)
ENSGAGP00000003720Deacetylase sirtuin-type domain-containing protein. (742 aa)
ENSGAGP00000003677Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (301 aa)
SETD7SET domain containing 7, histone lysine methyltransferase. (372 aa)
PRKAA2Non-specific serine/threonine protein kinase. (551 aa)
PLK1Serine/threonine-protein kinase PLK. (552 aa)
ENSGAGP00000002879Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (476 aa)
PRMT8Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (394 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (153 aa)
ENSGAGP00000002241Uncharacterized protein. (475 aa)
ENSGAGP00000002115Uncharacterized protein. (97 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (460 aa)
REM1RRAD and GEM like GTPase 1. (303 aa)
ENSGAGP00000001654Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (353 aa)
BCL6BCL6 transcription repressor. (709 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (161 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (286 aa)
RBL2RB transcriptional corepressor like 2. (1136 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (274 aa)
ENSGAGP00000000687Endo/exonuclease/phosphatase domain-containing protein. (481 aa)
GRM1Glutamate metabotropic receptor 1. (1192 aa)
FOXJ2Forkhead box J2. (545 aa)
HOMER1Homer scaffold protein 1. (290 aa)
Your Current Organism:
Gopherus agassizii
NCBI taxonomy Id: 38772
Other names: G. agassizii, Gopherus agassizi, Gopherus polyphemus agassizii, USNM 7888, desert tortoise
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