STRINGSTRING
ENSGAGP00000018492 ENSGAGP00000018492 ENSGAGP00000001654 ENSGAGP00000001654 ENSGAGP00000001758 ENSGAGP00000001758 REM1 REM1 CALM3 CALM3 MAPK3 MAPK3 ENSGAGP00000002581 ENSGAGP00000002581 ITPR1 ITPR1 ENSGAGP00000003377 ENSGAGP00000003377 ENSGAGP00000003418 ENSGAGP00000003418 ENSGAGP00000003443 ENSGAGP00000003443 ENSGAGP00000003498 ENSGAGP00000003498 ELK3 ELK3 PLA2G4F PLA2G4F HBEGF HBEGF ENSGAGP00000003930 ENSGAGP00000003930 MAP3K4 MAP3K4 MMP2 MMP2 MAP2K1 MAP2K1 MAPK10 MAPK10 ENSGAGP00000005774 ENSGAGP00000005774 ENSGAGP00000005967 ENSGAGP00000005967 ENSGAGP00000006624 ENSGAGP00000006624 ELK1 ELK1 ENSGAGP00000007093 ENSGAGP00000007093 MAPK7 MAPK7 GRB2 GRB2 MAPK13 MAPK13 PVALEF PVALEF PRKCA PRKCA GNRH1 GNRH1 ENSGAGP00000009134 ENSGAGP00000009134 MMP14 MMP14 ENSGAGP00000010073 ENSGAGP00000010073 ENSGAGP00000010139 ENSGAGP00000010139 ENSGAGP00000010433 ENSGAGP00000010433 PLCB4 PLCB4 ENSGAGP00000011178 ENSGAGP00000011178 MAPK11 MAPK11 MAPK12 MAPK12 MAPK14 MAPK14 MAP3K3 MAP3K3 PLA2G4A PLA2G4A MAP2K3 MAP2K3 ENSGAGP00000013368 ENSGAGP00000013368 CDC42 CDC42 ENSGAGP00000013836 ENSGAGP00000013836 CALML4 CALML4 KRAS KRAS ENSGAGP00000014602 ENSGAGP00000014602 MAP3K1 MAP3K1 ENSGAGP00000015025 ENSGAGP00000015025 SOS2 SOS2 ENSGAGP00000015213 ENSGAGP00000015213 ENSGAGP00000015430 ENSGAGP00000015430 ENSGAGP00000015633 ENSGAGP00000015633 ENSGAGP00000016145 ENSGAGP00000016145 MAPK9 MAPK9 ENSGAGP00000016352 ENSGAGP00000016352 ATF4 ATF4 CAMK2D CAMK2D CAMK2B CAMK2B ADCY8 ADCY8 ADCY1 ADCY1 ENSGAGP00000019829 ENSGAGP00000019829 PLCB1 PLCB1 ENSGAGP00000020334 ENSGAGP00000020334 PLCB2 PLCB2 SRC SRC SOS1 SOS1 PLD1 PLD1 ENSGAGP00000021093 ENSGAGP00000021093 ADCY9 ADCY9 PRKCD PRKCD ENSGAGP00000023042 ENSGAGP00000023042 PTX3 PTX3 CALML6 CALML6 ENSGAGP00000023351 ENSGAGP00000023351 CALM1 CALM1 CACNA1D CACNA1D ENSGAGP00000023811 ENSGAGP00000023811 ITPR2 ITPR2 ENSGAGP00000024034 ENSGAGP00000024034 ENSGAGP00000024038 ENSGAGP00000024038 NRAS NRAS CSDE1 CSDE1 ENSGAGP00000024279 ENSGAGP00000024279 MAP3K2 MAP3K2 PTK2B PTK2B PLCB3 PLCB3 ITPR3 ITPR3 GNA11 GNA11 ENSGAGP00000027018 ENSGAGP00000027018 ENSGAGP00000027029 ENSGAGP00000027029 ENSGAGP00000027353 ENSGAGP00000027353 ENSGAGP00000028199 ENSGAGP00000028199 MAPK1 MAPK1 MAP2K7 MAP2K7 ENSGAGP00000029623 ENSGAGP00000029623 RRAD RRAD FSHB FSHB RAF1 RAF1 ENSGAGP00000031727 ENSGAGP00000031727 JUN JUN MAP2K4 MAP2K4 MAPK8 MAPK8 ENSGAGP00000032760 ENSGAGP00000032760 CACNA1C CACNA1C ENSGAGP00000033336 ENSGAGP00000033336 JMJD7 JMJD7 ADCY3 ADCY3 PTRHD1 PTRHD1 ADCY2 ADCY2 ADCY6 ADCY6 EGR1 EGR1 GNAQ GNAQ GNAS GNAS MAP2K6 MAP2K6 CAMK2G CAMK2G
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSGAGP00000018492Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (287 aa)
ENSGAGP00000001654Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (353 aa)
ENSGAGP00000001758Uncharacterized protein. (339 aa)
REM1RRAD and GEM like GTPase 1. (303 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (217 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (460 aa)
ENSGAGP00000002581Uncharacterized protein. (628 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2752 aa)
ENSGAGP00000003377PX domain-containing protein. (201 aa)
ENSGAGP00000003418Uncharacterized protein; Belongs to the calmodulin family. (140 aa)
ENSGAGP00000003443EF-hand domain-containing protein; Belongs to the calmodulin family. (79 aa)
ENSGAGP00000003498C2 domain-containing protein. (128 aa)
ELK3ETS transcription factor ELK3. (425 aa)
PLA2G4FPhospholipase A2. (783 aa)
HBEGFHeparin binding EGF like growth factor. (296 aa)
ENSGAGP00000003930Protein kinase domain-containing protein. (558 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1334 aa)
MMP2Matrix metallopeptidase 2. (658 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (435 aa)
MAPK10Mitogen-activated protein kinase. (461 aa)
ENSGAGP00000005774PLA2c domain-containing protein. (229 aa)
ENSGAGP00000005967Uncharacterized protein. (92 aa)
ENSGAGP00000006624Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (525 aa)
ELK1ETS transcription factor ELK1. (135 aa)
ENSGAGP00000007093G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (374 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (1044 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
PVALEFParvalbumin like EF-hand containing. (134 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
GNRH1Gonadotropin releasing hormone 1. (92 aa)
ENSGAGP00000009134PLA2c domain-containing protein. (248 aa)
MMP14Matrix metallopeptidase 14. (510 aa)
ENSGAGP00000010073Uncharacterized protein. (241 aa)
ENSGAGP00000010139Uncharacterized protein. (415 aa)
ENSGAGP00000010433Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1349 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1093 aa)
ENSGAGP00000011178Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (395 aa)
MAPK11Mitogen-activated protein kinase. (361 aa)
MAPK12Mitogen-activated protein kinase. (361 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (640 aa)
PLA2G4APhospholipase A2. (678 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (348 aa)
ENSGAGP00000013368Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1086 aa)
CDC42Cell division cycle 42. (191 aa)
ENSGAGP00000013836Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (623 aa)
CALML4Calmodulin like 4. (153 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ENSGAGP00000014602Uncharacterized protein. (543 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1497 aa)
ENSGAGP00000015025Protein kinase domain-containing protein. (405 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1331 aa)
ENSGAGP00000015213Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (241 aa)
ENSGAGP00000015430G_PROTEIN_RECEP_F1_2 domain-containing protein. (426 aa)
ENSGAGP00000015633Uncharacterized protein. (186 aa)
ENSGAGP00000016145Uncharacterized protein; Belongs to the calmodulin family. (163 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ENSGAGP00000016352Cys_knot domain-containing protein. (136 aa)
ATF4Activating transcription factor 4. (354 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (472 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1232 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1140 aa)
ENSGAGP00000019829PLA2c domain-containing protein. (586 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1147 aa)
ENSGAGP00000020334Ca_chan_IQ domain-containing protein. (259 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1204 aa)
SRCTyrosine-protein kinase. (539 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1306 aa)
PLD1Phospholipase. (1036 aa)
ENSGAGP00000021093Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (580 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1348 aa)
PRKCDProtein kinase C delta. (350 aa)
ENSGAGP00000023042Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (113 aa)
PTX3Pentraxin 3. (430 aa)
CALML6Calmodulin like 6. (156 aa)
ENSGAGP00000023351Protein kinase domain-containing protein. (69 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2170 aa)
ENSGAGP00000023811annotation not available (149 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2699 aa)
ENSGAGP00000024034Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (98 aa)
ENSGAGP00000024038Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (91 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CSDE1Cold shock domain containing E1. (843 aa)
ENSGAGP00000024279PLA2c domain-containing protein. (491 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (613 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1014 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1171 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2663 aa)
GNA11G protein subunit alpha 11. (359 aa)
ENSGAGP00000027018Phospholipase A2. (730 aa)
ENSGAGP00000027029Phospholipase A2. (709 aa)
ENSGAGP00000027353Uncharacterized protein. (189 aa)
ENSGAGP00000028199Phospholipase A2. (687 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (419 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (438 aa)
ENSGAGP00000029623BZIP domain-containing protein. (367 aa)
RRADRRAD, Ras related glycolysis inhibitor and calcium channel regulator. (311 aa)
FSHBFollicle stimulating hormone subunit beta. (131 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (667 aa)
ENSGAGP00000031727Uncharacterized protein; Belongs to the calmodulin family. (178 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (313 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (450 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ENSGAGP00000032760Uncharacterized protein; Belongs to the protein kinase superfamily. (398 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2117 aa)
ENSGAGP00000033336G_PROTEIN_RECEP_F1_2 domain-containing protein. (411 aa)
JMJD7Jumonji domain containing 7. (310 aa)
ADCY3Adenylate cyclase 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (893 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (127 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (885 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (507 aa)
GNAQG protein subunit alpha q. (301 aa)
GNASGNAS complex locus. (379 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (394 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (629 aa)
Your Current Organism:
Gopherus agassizii
NCBI taxonomy Id: 38772
Other names: G. agassizii, Gopherus agassizi, Gopherus polyphemus agassizii, USNM 7888, desert tortoise
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