STRINGSTRING
SSA_0065 SSA_0065 secY secY rpoA rpoA rpoB rpoB rpoC rpoC tpx tpx SSA_0357 SSA_0357 SSA_0362 SSA_0362 SSA_0393 SSA_0393 SSA_0461 SSA_0461 SSA_0462 SSA_0462 SSA_0493 SSA_0493 SSA_0497 SSA_0497 SSA_0498 SSA_0498 SSA_0499 SSA_0499 SSA_0500 SSA_0500 SSA_0502 SSA_0502 secA secA SSA_0558 SSA_0558 mefE mefE sodA sodA SSA_0724 SSA_0724 SSA_0798 SSA_0798 SSA_0813 SSA_0813 secY2 secY2 secA2 secA2 SSA_0928 SSA_0928 SSA_0929 SSA_0929 pstS pstS SSA_1018 SSA_1018 SSA_1107 SSA_1107 SSA_1109 SSA_1109 SSA_1117 SSA_1117 SSA_1122 SSA_1122 pdhC pdhC acoC acoC bta bta SSA_1286 SSA_1286 SSA_1288 SSA_1288 phpA phpA SSA_1346 SSA_1346 SSA_1374 SSA_1374 SSA_1375 SSA_1375 pmrB pmrB SSA_1402 SSA_1402 SSA_1403 SSA_1403 tuf tuf secG secG pmrA pmrA rpoZ rpoZ SSA_1865 SSA_1865 mip mip SSA_1946 SSA_1946 SSA_1947 SSA_1947 phtA phtA SSA_2050 SSA_2050 SSA_2052 SSA_2052 SSA_2060 SSA_2060 SSA_2076 SSA_2076 SSA_2106 SSA_2106 SSA_2166 SSA_2166 SSA_2167 SSA_2167 secE secE SSA_2283 SSA_2283 SSA_2320 SSA_2320
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SSA_0065Low molecular weight phosphotyrosine protein phosphatase, putative; GC: 44.68%; Codon Adaptation Index (CAI): 0.79. Curator(s): J. Alves; Protein involved in protein amino acid dephosphorylation; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (140 aa)
secYMultispanning membrane protein, translocator of proteins, putative; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may mo [...] (435 aa)
rpoADNA-directed RNA polymerase, alpha chain, putative; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (312 aa)
rpoBDNA-directed RNA polymerase I, beta chain (140 kDa subunit), putative; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1127 aa)
rpoCDNA-directed RNA polymerase I, beta chain (160 kDa subunit), putative; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1215 aa)
tpxThiol peroxidase, putative; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily. (176 aa)
SSA_0357Thioredoxin, putative; GC: 45.71%; Codon Adaptation Index (CAI): 0.802. Curator(s): T. Kitten; Protein involved in electron transport; Belongs to the thioredoxin family. (104 aa)
SSA_0362Thioredoxin, putative; GC: 44.44%; Codon Adaptation Index (CAI): 0.8. Possibly an incomplete product. Curator(s): T. Kitten. (74 aa)
SSA_0393Bacteriocin ABC-type exporter, ATP binding/permease protein, putative; GC: 36.13%; Transporter classification TC:3.A.1.112.3. Transmembrane domains: 5. Codon Adaptation Index (CAI): 0.77. SignalP prediction: Yes (prob. 0.695); Curator(s): T. Kitten, J. Alves; Protein involved in ATPase activity, coupled to transmembrane movement of substances. (524 aa)
SSA_0461ABC-type multidrug transport system, ATPase and permease components, putative; GC: 47.43%; Transporter classification TC:3.A.1.117.1. Transmembrane domains: 6. Codon Adaptation Index (CAI): 0.771. Curator(s): M. Chaplin, J. Alves; Protein involved in ATPase activity, coupled to transmembrane movement of substances. (588 aa)
SSA_0462ATP-binding cassette, subfamily B, bacterial; GC: 47.33%; Transporter classification TC:3.A.1.106.1. Transmembrane domains: 5. Codon Adaptation Index (CAI): 0.777. SignalP prediction: Yes (prob. 0.48); Curator(s): M. Chaplin, J. Alves; Protein involved in ATPase activity, coupled to transmembrane movement of substances. (585 aa)
SSA_0493ABC-type dipeptide/nickel transport system, periplasmic component, putative; GC: 46.81%; Transporter classification TC:3.A.1.5.3. Codon Adaptation Index (CAI): 0.779. LipoP prediction: SpII. SignalP prediction: Yes (prob. 1); Curator(s): M. Chaplin, J. Alves; Protein involved in transport. (511 aa)
SSA_0497Nickel ABC transporter, putative; GC: 49.4%; Transporter classification TC:3.A.1.5.3. Transmembrane domains: 6. Codon Adaptation Index (CAI): 0.764. SignalP prediction: Yes (prob. 0.999); Curator(s): M. Chaplin. (331 aa)
SSA_0498ABC-type dipeptide/oligopeptide/nickel transport systems, permease components, putative; GC: 50%; Transporter classification TC:3.A.1.5.3. Transmembrane domains: 5. Codon Adaptation Index (CAI): 0.755. LipoP prediction: SpI. SignalP prediction: Yes (prob. 1); Curator(s): M. Chaplin, J. Alves. (269 aa)
SSA_0499ABC-type dipeptide transport system, periplasmic component, putative; GC: 45.02%; Transporter classification TC:3.A.1.5.3. Codon Adaptation Index (CAI): 0.803. Curator(s): M. Chaplin, J. Alves; Protein involved in transport. (498 aa)
SSA_0500Peptide ABC transporter, permease protein, putative; GC: 45.75%; Transporter classification TC:3.A.1.5.3. Transmembrane domains: 6. Codon Adaptation Index (CAI): 0.747. LipoP prediction: SpI. SignalP prediction: Yes (prob. 1); Curator(s): D. Akan. (313 aa)
SSA_0502Peptide ABC transporter, permease protein, putative; GC: 45.94%; Transporter classification TC:3.A.1.5.3. Transmembrane domains: 5. Codon Adaptation Index (CAI): 0.782. Curator(s): D. Akan. (229 aa)
secASecA, putative; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (839 aa)
SSA_0558Conserved hypothetical cytosolic protein, putative; GC: 38.73%; Codon Adaptation Index (CAI): 0.798. Curator(s): D. Akan. (104 aa)
mefEMacrolide-efflux protein, putative; GC: 45.79%; Transporter classification TC:2.A.1.21.1. Transmembrane domains: 12. Codon Adaptation Index (CAI): 0.759. Curator(s): D. Akan, J. Alves. (427 aa)
sodAMn/Fe-dependent superoxide dismutase, putative; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (201 aa)
SSA_0724Multidrug ABC transporter ATPase/permease; GC: 42.57%; Transporter classification TC:3.A.1.112.2. Transmembrane domains: 6. Codon Adaptation Index (CAI): 0.784. SignalP prediction: Yes (prob. 0.992); Curator(s): X. Ge, J. Alves; Protein involved in ATPase activity, coupled to transmembrane movement of substances. (526 aa)
SSA_0798ABC transporter membrane-spanning permease-macrolide efflux, putative; GC: 42.47%; Transmembrane domains: 10. Codon Adaptation Index (CAI): 0.763. Curator(s): X. Ge. (393 aa)
SSA_0813Thioredoxin reductase, putative; GC: 47.57%; Codon Adaptation Index (CAI): 0.781. Curator(s): X. Ge; Protein involved in oxidoreductase activity. (322 aa)
secY2SecY-like protein, putative; Part of the accessory SecA2/SecY2 system specifically required for export of possible cell wall proteins. The central subunit of a protein translocation channel. (407 aa)
secA2SecA-like protein, putative; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (793 aa)
SSA_0928ABC-type multidrug transporter, ATPase and permease components, putative; GC: 45.16%; Transporter classification TC:3.A.1.21.1. Transmembrane domains: 5. Codon Adaptation Index (CAI): 0.794. SignalP prediction: Yes (prob. 0.563); Curator(s): T. Kitten, J. Alves; Protein involved in ATPase activity, coupled to transmembrane movement of substances. (588 aa)
SSA_0929ABC-type multidrug transporter, ATPase and permease components, putative; GC: 46.28%; Transporter classification TC:3.A.1.21.1. Transmembrane domains: 6. Codon Adaptation Index (CAI): 0.78. Curator(s): T. Kitten, J. Alves; Protein involved in ATPase activity, coupled to transmembrane movement of substances. (581 aa)
pstSABC-type phosphate transport system, periplasmic component, putative; GC: 45.42%; Transporter classification TC:3.A.1.7.1. Codon Adaptation Index (CAI): 0.781. Curator(s): T. Kitten; Protein involved in transport. (293 aa)
SSA_1018Zinc metalloprotease zmpC precursor, putative; GC: 45.25%; Transmembrane domains: 3. Codon Adaptation Index (CAI): 0.781. LipoP prediction: SpI. SignalP prediction: Yes (prob. 1); Protein involved in metal ion binding. (3047 aa)
SSA_1107Lipid/multidrug/protein-type ABC exporter, ATP binding/membrane-spanning protein, putative; GC: 46.86%; Transporter classification TC:3.A.1.106.1. Transmembrane domains: 6. Codon Adaptation Index (CAI): 0.777; Protein involved in ATPase activity, coupled to transmembrane movement of substances. (578 aa)
SSA_1109ABC transporter ATP binding/permease protein, putative; GC: 44.29%; Transporter classification TC:3.A.1.106.1. Transmembrane domains: 5. Codon Adaptation Index (CAI): 0.802. SignalP prediction: Yes (prob. 0.483); Helix-turn-helix prediction: AraC; Protein involved in ATPase activity, coupled to transmembrane movement of substances. (592 aa)
SSA_1117Conserved hypothetical protein; GC: 40.6%; Codon Adaptation Index (CAI): 0.797. LipoP prediction: SpII. SignalP prediction: Yes (prob. 0.995); Protein involved in electron carrier activity. (187 aa)
SSA_1122Thioredoxin family protein, putative; GC: 43.06%; Codon Adaptation Index (CAI): 0.801. LipoP prediction: SpII. SignalP prediction: Yes (prob. 0.998); Protein involved in electron carrier activity. (191 aa)
pdhCDihydrolipoamide acetyl transferase, E2 component, putative; GC: 46.9%; Codon Adaptation Index (CAI): 0.759; Protein involved in acyltransferase activity and transferase activity. (419 aa)
acoCAcetoin dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase, putative; GC: 44.06%; Codon Adaptation Index (CAI): 0.798; Protein involved in acyltransferase activity and transferase activity. (347 aa)
btaBta, putative; GC: 42.24%; Codon Adaptation Index (CAI): 0.826; Protein involved in electron transport and drug transport. (115 aa)
SSA_1286Conserved hypothetical protein; GC: 29.22%; Codon Adaptation Index (CAI): 0.751. Curator(s): J. Alves. (161 aa)
SSA_1288Conserved hypothetical protein; GC: 30.23%; Codon Adaptation Index (CAI): 0.74. Curator(s): J. Alves. (160 aa)
phpAPneumococcal histidine triad protein D precursor, putative; GC: 47.66%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.769. LipoP prediction: SpI. SignalP prediction: Yes (prob. 0.72); Helix-turn-helix prediction: AraC. (1181 aa)
SSA_1346Conserved hypothetical protein; GC: 40.28%; Transmembrane domains: 6. Codon Adaptation Index (CAI): 0.781. (210 aa)
SSA_1374Multidrug ABC transporter, ATPase and permease components, putative; GC: 47.27%; Transporter classification TC:3.A.1.106.1. Transmembrane domains: 5. Codon Adaptation Index (CAI): 0.752. SignalP prediction: Yes (prob. 0.984); Curator(s): J. Alves; Protein involved in ATPase activity, coupled to transmembrane movement of substances. (578 aa)
SSA_1375Multidrug ABC transporter, ATPase and permease components, putative; GC: 48.48%; Transporter classification TC:3.A.1.117.1. Transmembrane domains: 6. Codon Adaptation Index (CAI): 0.783. Curator(s): J. Alves; Protein involved in ATPase activity, coupled to transmembrane movement of substances. (580 aa)
pmrBTransport protein, putative; GC: 41.92%; Transmembrane domains: 9. Codon Adaptation Index (CAI): 0.769. (395 aa)
SSA_1402ABC-type multidrug transport system, ATPase and permease components, putative; GC: 45.8%; Transporter classification TC:3.A.1.106.1. Transmembrane domains: 5. Codon Adaptation Index (CAI): 0.778. SignalP prediction: Yes (prob. 0.98); Curator(s): J. Alves; Protein involved in ATPase activity, coupled to transmembrane movement of substances. (579 aa)
SSA_1403Multidrug ABC transporter, ATPase and permease components, putative; GC: 47.1%; Transporter classification TC:3.A.1.106.1. Transmembrane domains: 6. Codon Adaptation Index (CAI): 0.775. SignalP prediction: Yes (prob. 0.997); Helix-turn-helix prediction: AraC. Curator(s): J. Alves; Protein involved in ATPase activity, coupled to transmembrane movement of substances. (580 aa)
tufElongation factor Tu, putative; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (398 aa)
secGProtein-export membrane protein secG, putative; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (77 aa)
pmrAMajor facilitator superfamily multi-drug resistance efflux pump pmrA, putative; GC: 48.02%; Transporter classification TC:2.A.1.2.20. Transmembrane domains: 10. Codon Adaptation Index (CAI): 0.739. Helix-turn-helix prediction: AraC. Curator(s): J. Alves. (369 aa)
rpoZDNA-directed RNA polymerase, subunit K/omega, putative; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (104 aa)
SSA_1865Thioredoxin reductase, putative; GC: 48.63%; Codon Adaptation Index (CAI): 0.781; Protein involved in removal of superoxide radicals. (304 aa)
mipMacrophage infectivity potentiator protein, putative; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. (186 aa)
SSA_1946Oligopeptide transport system permease protein, putative; GC: 40.99%; Transporter classification TC:3.A.1.5.2. Transmembrane domains: 6. Codon Adaptation Index (CAI): 0.796. (308 aa)
SSA_1947Oligopeptide transport system permease protein, putative; GC: 41.42%; Transporter classification TC:3.A.1.5.2. Transmembrane domains: 6. Codon Adaptation Index (CAI): 0.816. SignalP prediction: Yes (prob. 0.769). (498 aa)
phtAPneumococcal histidine triad protein A, putative; GC: 39.29%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.789. LipoP prediction: SpI. SignalP prediction: Yes (prob. 0.453). (810 aa)
SSA_2050Arabinose efflux permease, putative; GC: 42.73%; Transporter classification TC:2.A.1.3.4. Transmembrane domains: 14. Codon Adaptation Index (CAI): 0.73. Curator(s): J. Alves; Protein involved in response to antibiotic. (453 aa)
SSA_2052Thioredoxin, putative; GC: 47.62%; Codon Adaptation Index (CAI): 0.792; Protein involved in electron transport; Belongs to the thioredoxin family. (104 aa)
SSA_2060Arabinose efflux permease, putative; GC: 46.24%; Transporter classification TC:2.A.1.15.4. Transmembrane domains: 10. Codon Adaptation Index (CAI): 0.759. LipoP prediction: SpI. SignalP prediction: Yes (prob. 1); Curator(s): J. Alves. (389 aa)
SSA_2076Conserved uncharacterized protein; GC: 45.7%; Codon Adaptation Index (CAI): 0.808. (363 aa)
SSA_2106Flavin monoxygenase, putative; GC: 53.43%; Codon Adaptation Index (CAI): 0.755. Curator(s): J. Alves. (349 aa)
SSA_2166ABC-type multidrug transporter, ATPase and permease components, putative; GC: 47.51%; Transporter classification TC:3.A.1.106.1. Transmembrane domains: 5. Codon Adaptation Index (CAI): 0.772. SignalP prediction: Yes (prob. 0.969); Curator(s): J. Alves; Protein involved in ATPase activity, coupled to transmembrane movement of substances. (589 aa)
SSA_2167ABC-type multidrug transporter, ATPase and permease components, putative; GC: 47.28%; Transporter classification TC:3.A.1.201.1. Transmembrane domains: 6. Codon Adaptation Index (CAI): 0.763. SignalP prediction: Yes (prob. 0.592); Helix-turn-helix prediction: AraC. Curator(s): J. Alves; Protein involved in ATPase activity, coupled to transmembrane movement of substances. (575 aa)
secEPreprotein translocase secE component, putative; GC: 32.22%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.783. Curator(s): J. Alves; Belongs to the SecE/SEC61-gamma family. (59 aa)
SSA_2283Conserved uncharacterized protein; GC: 35.76%; Codon Adaptation Index (CAI): 0.829. Curator(s): J. Alves; Belongs to the WXG100 family. (95 aa)
SSA_2320Hypothetical protein; GC: 39.71%; Transmembrane domains: 3. Codon Adaptation Index (CAI): 0.766. LipoP prediction: SpI. SignalP prediction: Yes (prob. 1); Curator(s): J. Alves. (1164 aa)
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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