STRINGSTRING
PNK_2321 PNK_2321 PNK_2275 PNK_2275 pbp2 pbp2 PNK_2238 PNK_2238 pal pal tolR tolR tolQ tolQ PNK_2190 PNK_2190 panF panF PNK_2155 PNK_2155 yajC yajC mdtA mdtA lnt lnt atkC atkC atkB atkB atkA atkA PNK_1418 PNK_1418 mscL mscL PNK_1470 PNK_1470 dacA dacA PNK_1616 PNK_1616 acrA acrA PNK_1838 PNK_1838 lepB lepB uppP uppP metI metI secY secY trkA trkA PNK_2344 PNK_2344 PNK_2348 PNK_2348 kdpC kdpC kdpB kdpB PNK_0017 PNK_0017 PNK_0042 PNK_0042 napA napA secA secA rodA rodA kdpA kdpA PNK_0181 PNK_0181 wza wza PNK_0278 PNK_0278 folK folK PNK_0413 PNK_0413 acrb1 acrb1 PNK_0424 PNK_0424 corA corA pbp1 pbp1 PNK_0581 PNK_0581 mraY mraY ftsW ftsW PNK_0665 PNK_0665 PNK_0666 PNK_0666 cyoD cyoD PNK_0748 PNK_0748 lgt lgt yidC yidC PNK_0876 PNK_0876 PNK_0882 PNK_0882 PNK_0899 PNK_0899 potA potA potB potB PNK_1102 PNK_1102 PNK_1133 PNK_1133 crcB crcB PNK_1275 PNK_1275 PNK_1330 PNK_1330 PNK_1340 PNK_1340 PNK_1415 PNK_1415 PNK_1416 PNK_1416
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PNK_2321Hypothetical protein. (547 aa)
PNK_2275ABC-type transporter, permease protein. (411 aa)
pbp2Penicillin-binding protein. (1158 aa)
PNK_2238Hypothetical protein. (205 aa)
palPeptidoglycan-associated lipoprotein precursor; Belongs to the Pal lipoprotein family. (260 aa)
tolRPutative biopolymer transport protein TolR. (142 aa)
tolQProtein TolQ. (250 aa)
PNK_2190Conserved hypothetical protein. (349 aa)
panFSodium/pantothenate symporter (pantothenate permease); Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (375 aa)
PNK_2155ABC-type transporter, ATPase subunit. (251 aa)
yajCPutative preprotein translocase subunit YajC; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (132 aa)
mdtAPutative multidrug resistance protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (386 aa)
lntApolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. (570 aa)
atkCPotassium-transporting ATPase, subunit C; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (180 aa)
atkBPotassium-transporting ATPase, subunit B; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (692 aa)
atkAPotassium-transporting ATPase, subunit A; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. (557 aa)
PNK_1418Hypothetical protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (272 aa)
mscLLarge-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. (143 aa)
PNK_1470Putative serine/threonine PP2C protein phosphatase. (254 aa)
dacAConserved hypothetical membrane protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (267 aa)
PNK_1616Hypothetical protein. (438 aa)
acrAMultidrug-efflux transport protein acrA; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (380 aa)
PNK_1838Conserved hypothetical membrane protein. (159 aa)
lepBPutative signal peptidase I; Belongs to the peptidase S26 family. (635 aa)
uppPUndecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (257 aa)
metID-methionine transport system permease protein. (228 aa)
secYPreprotein translocase subunit secY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (456 aa)
trkAPotassium uptake system, Trk family. (453 aa)
PNK_2344ABC-type transporter, permease subunit. (256 aa)
PNK_2348Conserved hypothetical protein. (205 aa)
kdpCPotassium-transporting ATPase C chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (184 aa)
kdpBPotassium-transporting ATPase B chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (692 aa)
PNK_0017Hypothetical protein. (400 aa)
PNK_0042Conserved putative secreted protein. (245 aa)
napASodium:proton antiporter. (409 aa)
secAPreprotein translocase subunit secA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (1024 aa)
rodASeptum-peptidoglycan biosynthetic protein; Belongs to the SEDS family. (378 aa)
kdpAPotassium-transporting ATPase A chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. (560 aa)
PNK_0181ABC-2 type transporter family protein. (279 aa)
wzaPutative polysaccharide export protein. (381 aa)
PNK_0278Putative ABC-type transporter, ATPase subunit. (287 aa)
folKPutative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. (189 aa)
PNK_0413Putative ABC-type transporter, ATPase subunit. (246 aa)
acrb1Multidrug-efflux transport protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1072 aa)
PNK_0424HlyD family secretion protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (407 aa)
corAMagnesium and cobalt transporter family protein; Mediates influx of magnesium ions. Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. (354 aa)
pbp1Penicillin-binding protein. (675 aa)
PNK_0581Hypothetical protein. (59 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (412 aa)
ftsWCell division protein FtsW; Belongs to the SEDS family. (372 aa)
PNK_0665Hypothetical protein. (412 aa)
PNK_0666Conserved hypothetical secreted protein. (193 aa)
cyoDPutative cytochrome o ubiquinol oxidase, subunit IV. (119 aa)
PNK_0748Conserved putative membrane protein. (136 aa)
lgtProlipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (388 aa)
yidCInner membrane protein translocase component YidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (829 aa)
PNK_0876Hypothetical protein; Belongs to the MlaE permease family. (270 aa)
PNK_0882ABC-type transporter, permease subunit; Belongs to the binding-protein-dependent transport system permease family. (292 aa)
PNK_0899Putative phosphoprotein phosphatase. (451 aa)
potASpermidine/putrescine import ATP-binding protein PotA; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family. (373 aa)
potBPutative ABC-type spermidine/putrescine transport system, permease subunit I. (306 aa)
PNK_1102Hypothetical protein. (282 aa)
PNK_1133ABC-type transporter, permease subunit; Belongs to the binding-protein-dependent transport system permease family. (286 aa)
crcBcrcB Protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family. (129 aa)
PNK_1275Hypothetical membrane protein. (168 aa)
PNK_1330Conserved putative membrane protein. (228 aa)
PNK_1340Hypothetical protein. (608 aa)
PNK_1415Putative permease, YjgP/YjgQ family. (383 aa)
PNK_1416Putative permease, YjgP/YjgQ family. (364 aa)
Your Current Organism:
Protochlamydia naegleriophila
NCBI taxonomy Id: 389348
Other names: C. Protochlamydia naegleriophila, Candidatus Protochlamydia naegleriophila, strain KNic
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