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eno eno deoC deoC Tmel_0676 Tmel_0676 Tmel_0757 Tmel_0757 pfp pfp Tmel_0866 Tmel_0866 Tmel_0922 Tmel_0922 Tmel_1141 Tmel_1141 Tmel_1182 Tmel_1182 tpiA tpiA pgk pgk Tmel_1266 Tmel_1266 Tmel_1272 Tmel_1272 Tmel_1525 Tmel_1525 pfkA pfkA tal tal Tmel_1753 Tmel_1753 Tmel_1834 Tmel_1834 pgi pgi Tmel_1902 Tmel_1902
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (241 aa)
Tmel_0676PFAM: PfkB domain protein; Belongs to the carbohydrate kinase PfkB family. (317 aa)
Tmel_0757PFAM: phosphoglucomutase/phosphomannomutase C terminal; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III. (574 aa)
pfpPhosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (394 aa)
Tmel_0866TIGRFAM: fructose-1,6-bisphosphatase, class II; PFAM: GlpX family protein. (338 aa)
Tmel_0922TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; Belongs to the pyruvate kinase family. (470 aa)
Tmel_1141PFAM: ROK family protein. (308 aa)
Tmel_1182TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase. (145 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (240 aa)
pgkPFAM: phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (402 aa)
Tmel_1266TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
Tmel_1272TIGRFAM: ketose-bisphosphate aldolase; fructose-1,6-bisphosphate aldolase, class II; PFAM: ketose-bisphosphate aldolase, class-II. (311 aa)
Tmel_1525PFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (214 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa)
talPutative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (216 aa)
Tmel_1753PFAM: Transketolase domain protein; Transketolase, central region. (618 aa)
Tmel_1834PFAM: PfkB domain protein; Belongs to the carbohydrate kinase PfkB family. (306 aa)
pgiPFAM: phosphoglucose isomerase (PGI); Belongs to the GPI family. (450 aa)
Tmel_19026-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (335 aa)
Your Current Organism:
Thermosipho melanesiensis
NCBI taxonomy Id: 391009
Other names: T. melanesiensis BI429, Thermosipho melanesiensis BI429, Thermosipho melanesiensis str. BI429, Thermosipho melanesiensis strain BI429
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