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sdhC sdhC pdxH pdxH pyrD pyrD EHF_0844 EHF_0844 dapB dapB EHF_0397 EHF_0397 EHF_0402 EHF_0402 tkt tkt EHF_0418 EHF_0418 sodB sodB ispH ispH EHF_0453 EHF_0453 petA petA petB petB petC petC EHF_0482 EHF_0482 nuoF nuoF EHF_0500 EHF_0500 nuoK nuoK EHF_0502 EHF_0502 EHF_0503 EHF_0503 nuoN nuoN dxr dxr ispG ispG EHF_0528 EHF_0528 EHF_0531 EHF_0531 nuoE nuoE nuoD nuoD nuoH nuoH nuoG nuoG mdh mdh EHF_0578 EHF_0578 EHF_0595 EHF_0595 fabG fabG EHF_0002 EHF_0002 EHF_0011 EHF_0011 asd asd proC proC gap gap icd icd EHF_0095 EHF_0095 EHF_0098 EHF_0098 EHF_0112 EHF_0112 grxC grxC argC argC ctaD ctaD coxB coxB EHF_0189 EHF_0189 trxA trxA pdhA pdhA guaB guaB EHF_0209 EHF_0209 EHF_0248 EHF_0248 ctaA ctaA grxD grxD EHF_0260 EHF_0260 sdhA sdhA sdhD sdhD EHF_0272 EHF_0272 folD folD EHF_0283 EHF_0283 EHF_0284 EHF_0284 EHF_0294 EHF_0294 EHF_0318 EHF_0318 EHF_0320 EHF_0320 EHF_0336 EHF_0336 EHF_0386 EHF_0386 EHF_0845 EHF_0845 EHF_0860 EHF_0860 EHF_0867 EHF_0867 EHF_0878 EHF_0878 EHF_0881 EHF_0881 tme tme ribD ribD EHF_0902 EHF_0902 EHF_0914 EHF_0914 EHF_0915 EHF_0915 EHF_0916 EHF_0916 EHF_0974 EHF_0974 EHF_0994 EHF_0994 nuoI nuoI EHF_0644 EHF_0644 trxB trxB EHF_0664 EHF_0664 EHF_0670 EHF_0670 EHF_0674 EHF_0674 EHF_0680 EHF_0680 nuoA nuoA nuoB nuoB nuoC nuoC fabI fabI sucA sucA ubiB ubiB EHF_0762 EHF_0762 EHF_0763 EHF_0763 EHF_0782 EHF_0782
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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sdhCSuccinate dehydrogenase, cytochrome b556 subunit. (128 aa)
pdxHPyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (197 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (350 aa)
EHF_0844Prokaryotic cytochrome b561 family protein. (176 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (267 aa)
EHF_0397FAD dependent oxidoreductase family protein. (354 aa)
EHF_0402Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (595 aa)
tktTransketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (663 aa)
EHF_0418NADH-Ubiquinone/plastoquinone (complex I), various chains family protein. (529 aa)
sodBSuperoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (205 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (319 aa)
EHF_0453Dihydrolipoyl dehydrogenase. (465 aa)
petAUbiquinol-cytochrome c reductase, iron-sulfur subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (187 aa)
petBCytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (377 aa)
petCCytochrome c1. (251 aa)
EHF_0482Putative peroxiredoxin bcp. (145 aa)
nuoFNADH oxidoreductase (quinone), F subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (420 aa)
EHF_0500NADH-ubiquinone/plastoquinone oxidoreductase chain 6 family protein; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (200 aa)
nuoKNADH-ubiquinone/plastoquinone oxidoreductase chain 4L family protein; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (108 aa)
EHF_0502Proton-translocating NADH-quinone oxidoreductase, chain L family protein. (621 aa)
EHF_0503Proton-translocating NADH-quinone oxidoreductase, chain M family protein. (478 aa)
nuoNProton-translocating NADH-quinone oxidoreductase, chain N family protein; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (475 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (372 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (422 aa)
EHF_05283-hydroxyacyl-CoA dehydrogenase, C-terminal domain protein. (401 aa)
EHF_0531Coproporphyrinogen III oxidase family protein; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (284 aa)
nuoENADH-quinone oxidoreductase, E subunit. (181 aa)
nuoDNADH dehydrogenase (quinone), D subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 49 kDa subunit family. (384 aa)
nuoHNADH-ubiquinone oxidoreductase chain 1; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. (367 aa)
nuoGNADH dehydrogenase (quinone), G subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (684 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (313 aa)
EHF_0578Pyridine nucleotide-disulfide oxidoreductase family protein. (337 aa)
EHF_0595Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1043 aa)
fabG3-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (248 aa)
EHF_0002Cytochrome c oxidase subunit 3. (274 aa)
EHF_0011Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family protein. (392 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (336 aa)
proCNADP oxidoreductase coenzyme F420-dependent family protein; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (269 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase, type I; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
icdIsocitrate dehydrogenase. (482 aa)
EHF_0095Iron-containing alcohol dehydrogenase family protein. (420 aa)
EHF_0098Cytochrome C and Quinol oxidase polypeptide I family protein. (333 aa)
EHF_0112Cytochrome C biogenesis transmembrane region family protein. (405 aa)
grxCGlutaredoxin 3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. (81 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa)
ctaDCytochrome c oxidase, subunit I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (518 aa)
coxBCytochrome c oxidase, subunit II; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). (232 aa)
EHF_0189ETC complex I subunit conserved region family protein. (97 aa)
trxAThioredoxin; Belongs to the thioredoxin family. (107 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (319 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (485 aa)
EHF_0209Nitronate monooxygenase family protein. (467 aa)
EHF_0248DSBA-like thioredoxin domain protein. (246 aa)
ctaACytochrome oxidase assembly family protein; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. (344 aa)
grxDMonothiol glutaredoxin, Grx4 family; Belongs to the glutaredoxin family. Monothiol subfamily. (110 aa)
EHF_0260ahpC/TSA family protein. (149 aa)
sdhASuccinate dehydrogenase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (598 aa)
sdhDSuccinate dehydrogenase, hydrophobic membrane anchor protein. (118 aa)
EHF_0272Succinate dehydrogenase and fumarate reductase iron-sulfur family protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (258 aa)
folDTetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (298 aa)
EHF_0283Cytochrome c family protein. (172 aa)
EHF_0284NADH-Ubiquinone/plastoquinone (complex I), various chains family protein. (494 aa)
EHF_0294NAD-dependent glycerol-3-phosphate dehydrogenase family protein; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (308 aa)
EHF_0318Short chain dehydrogenase family protein. (242 aa)
EHF_0320Dioxygenase family protein. (224 aa)
EHF_0336Zinc-binding dehydrogenase family protein. (324 aa)
EHF_0386Flavin reductase like domain protein. (164 aa)
EHF_0845Nitronate monooxygenase family protein. (342 aa)
EHF_0860Dihydrolipoyl dehydrogenase. (471 aa)
EHF_0867Short chain dehydrogenase family protein. (232 aa)
EHF_0878Hypothetical protein. (97 aa)
EHF_0881NADH-Ubiquinone/plastoquinone (complex I), various chains family protein. (491 aa)
tmeNADP-dependent malic enzyme. (759 aa)
ribDRiboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (359 aa)
EHF_0902Thioredoxin-like family protein. (182 aa)
EHF_0914Transketolase, pyrimidine binding domain protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (332 aa)
EHF_0915Hypothetical protein. (144 aa)
EHF_0916ahpC/TSA family protein. (193 aa)
EHF_0974NAD dependent epimerase/dehydratase family protein. (320 aa)
EHF_09944Fe-4S binding domain protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (94 aa)
nuoINADH-quinone oxidoreductase, chain I family protein; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (143 aa)
EHF_0644ahpC/TSA family protein. (205 aa)
trxBThioredoxin-disulfide reductase. (318 aa)
EHF_0664TIM-barrel, nifR3 family protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (317 aa)
EHF_0670Ribonucleotide reductase, small chain family protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (327 aa)
EHF_0674Bacterial NAD-glutamate dehydrogenase family protein. (1583 aa)
EHF_0680Pyridine nucleotide-disulfide oxidoreductase family protein. (1128 aa)
nuoANADH-ubiquinone/plastoquinone oxidoreductase, chain 3 family protein; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 3 family. (123 aa)
nuoBNADH-quinone oxidoreductase, B subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (177 aa)
nuoCNADH-quinone oxidoreductase, subunit C; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 30 kDa subunit family. (192 aa)
fabIEnoyl-[acyl-carrier-protein] reductase. (266 aa)
sucAOxoglutarate dehydrogenase (succinyl-transferring), E1 component. (912 aa)
ubiB2-polyprenylphenol 6-hydroxylase. (480 aa)
EHF_0762Ubiquinone biosynthesis COQ7 family protein; Belongs to the COQ7 family. (170 aa)
EHF_0763Disulfide bond formation DsbB family protein. (159 aa)
EHF_0782Rhodanese-like domain protein; Belongs to the UPF0176 family. (275 aa)
Your Current Organism:
Ehrlichia sp. HF
NCBI taxonomy Id: 391036
Other names: E. sp. HF
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