STRINGSTRING
EHF_0503 EHF_0503 nuoK nuoK EHF_0500 EHF_0500 yihY yihY petA petA EHF_0460 EHF_0460 EHF_0454 EHF_0454 EHF_0436 EHF_0436 EHF_0423 EHF_0423 era era EHF_0418 EHF_0418 EHF_0413 EHF_0413 pstB pstB EHF_0383 EHF_0383 EHF_0382 EHF_0382 secY secY sppA sppA ccmC ccmC EHF_0274 EHF_0274 EHF_0272 EHF_0272 EHF_0263 EHF_0263 EHF_0255 EHF_0255 ccmA ccmA EHF_0223 EHF_0223 EHF_0219 EHF_0219 EHF_0204 EHF_0204 EHF_0187 EHF_0187 yajC yajC EHF_0148 EHF_0148 hflC hflC lspA lspA EHF_0112 EHF_0112 rseP rseP ftsA ftsA EHF_0089 EHF_0089 hflB hflB ftsH ftsH lgt lgt secD secD ftsY ftsY secA secA EHF_0031 EHF_0031 plsY plsY EHF_0002 EHF_0002 EHF_0682 EHF_0682 EHF_0683 EHF_0683 agcS agcS nuoA nuoA nuoB nuoB EHF_0693 EHF_0693 dnaA dnaA EHF_0717 EHF_0717 EHF_0718 EHF_0718 EHF_0735 EHF_0735 znuC znuC EHF_0741 EHF_0741 EHF_0763 EHF_0763 EHF_0773 EHF_0773 EHF_0776 EHF_0776 EHF_0777 EHF_0777 EHF_0778 EHF_0778 EHF_0792 EHF_0792 sdhD sdhD EHF_0823 EHF_0823 secE secE EHF_0842 EHF_0842 EHF_0843 EHF_0843 EHF_0844 EHF_0844 pstC pstC EHF_0869 EHF_0869 EHF_0879 EHF_0879 EHF_0881 EHF_0881 lnt lnt EHF_0884 EHF_0884 lolD lolD EHF_0891 EHF_0891 EHF_0897 EHF_0897 EHF_0917 EHF_0917 EHF_0924 EHF_0924 EHF_0936 EHF_0936 secF secF EHF_0959 EHF_0959 EHF_0970 EHF_0970 EHF_0972 EHF_0972 nuoN nuoN tatC tatC EHF_0509 EHF_0509 EHF_0513 EHF_0513 nuoE nuoE nuoH nuoH EHF_0565 EHF_0565 EHF_0595 EHF_0595 lepB lepB nuoI nuoI lepA lepA EHF_0675 EHF_0675
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EHF_0503Proton-translocating NADH-quinone oxidoreductase, chain M family protein. (478 aa)
nuoKNADH-ubiquinone/plastoquinone oxidoreductase chain 4L family protein; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (108 aa)
EHF_0500NADH-ubiquinone/plastoquinone oxidoreductase chain 6 family protein; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (200 aa)
yihYyihY family inner membrane domain protein. (278 aa)
petAUbiquinol-cytochrome c reductase, iron-sulfur subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (187 aa)
EHF_0460ABC 3 transport family protein. (267 aa)
EHF_0454Efflux transporter, RND family, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (357 aa)
EHF_0436Binding--dependent transport system inner membrane component family protein. (106 aa)
EHF_0423Metallopeptidase M24 family protein. (573 aa)
eraGTP-binding protein Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (287 aa)
EHF_0418NADH-Ubiquinone/plastoquinone (complex I), various chains family protein. (529 aa)
EHF_0413Ribonuclease, Rne/Rng family domain protein. (614 aa)
pstBPhosphate ABC transporter, ATP-binding protein; Belongs to the ABC transporter superfamily. (253 aa)
EHF_0383Alanine symporter family protein. (437 aa)
EHF_0382comEC/Rec2-related domain protein. (672 aa)
secYPreprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (432 aa)
sppASignal peptide peptidase SppA, 36K type. (288 aa)
ccmCHeme exporter CcmC family protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. (206 aa)
EHF_0274Drug resistance transporter, Bcr/CflA subfamily protein. (403 aa)
EHF_0272Succinate dehydrogenase and fumarate reductase iron-sulfur family protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (258 aa)
EHF_0263Colicin V production family protein. (202 aa)
EHF_0255HAMP domain protein. (713 aa)
ccmAHeme ABC exporter, ATP-binding protein CcmA; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. (217 aa)
EHF_0223Cytidylyltransferase family protein; Belongs to the CDS family. (218 aa)
EHF_0219Hypothetical protein. (995 aa)
EHF_0204Major Facilitator Superfamily protein. (412 aa)
EHF_0187Membrane transport family protein. (305 aa)
yajCPreprotein translocase, YajC subunit; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (123 aa)
EHF_0148cobQ/CobB/MinD/ParA nucleotide binding domain protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (353 aa)
hflChflC protein; HflC and HflK could regulate a protease. (290 aa)
lspASignal peptidase II; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. (128 aa)
EHF_0112Cytochrome C biogenesis transmembrane region family protein. (405 aa)
rsePRIP metalloprotease RseP. (355 aa)
ftsACell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (415 aa)
EHF_0089Cation transport family protein; Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA; Belongs to the TrkH potassium transport family. (485 aa)
hflBATP-dependent metallopeptidase HflB family protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (466 aa)
ftsHATP-dependent zinc metalloprotease FtsH domain protein. (77 aa)
lgtProlipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (261 aa)
secDProtein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (505 aa)
ftsYSignal recognition particle-docking protein FtsY. (319 aa)
secAPreprotein translocase, SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. (862 aa)
EHF_0031cobQ/CobB/MinD/ParA nucleotide binding domain protein. (260 aa)
plsYAcyl-phosphate glycerol 3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (196 aa)
EHF_0002Cytochrome c oxidase subunit 3. (274 aa)
EHF_0682Phosphatidylserine decarboxylase family protein. (146 aa)
EHF_0683CDP-alcohol phosphatidyltransferase family protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (259 aa)
agcSAmino acid carrier family protein. (460 aa)
nuoANADH-ubiquinone/plastoquinone oxidoreductase, chain 3 family protein; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 3 family. (123 aa)
nuoBNADH-quinone oxidoreductase, B subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (177 aa)
EHF_0693ccmE family protein; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. (116 aa)
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (464 aa)
EHF_0717Sugar (and other) transporter family protein. (411 aa)
EHF_0718Sugar (and other) transporter family protein. (412 aa)
EHF_0735Major Facilitator Superfamily protein. (401 aa)
znuCABC transporter family protein; Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family. (242 aa)
EHF_0741ABC transporter family protein; Belongs to the ABC transporter superfamily. (340 aa)
EHF_0763Disulfide bond formation DsbB family protein. (159 aa)
EHF_0773His Kinase A domain protein. (436 aa)
EHF_0776ftsK/SpoIIIE family protein. (834 aa)
EHF_0777YGGT family protein. (64 aa)
EHF_0778Transporter associated domain protein. (430 aa)
EHF_0792Phosphatidylglycerophosphatase A family protein; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). (163 aa)
sdhDSuccinate dehydrogenase, hydrophobic membrane anchor protein. (118 aa)
EHF_0823Putative membrane protein. (138 aa)
secEPreprotein translocase, SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. (65 aa)
EHF_0842Type I secretion membrane fusion, HlyD family protein. (505 aa)
EHF_0843Binding--dependent transport system inner membrane component family protein. (521 aa)
EHF_0844Prokaryotic cytochrome b561 family protein. (176 aa)
pstCPhosphate ABC transporter, permease protein PstC; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (292 aa)
EHF_0869Sugar (and other) transporter family protein. (422 aa)
EHF_0879Mce related family protein. (149 aa)
EHF_0881NADH-Ubiquinone/plastoquinone (complex I), various chains family protein. (491 aa)
lntApolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. (489 aa)
EHF_0884asmA family protein. (882 aa)
lolDABC transporter family protein; Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner. Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family. (225 aa)
EHF_0891Preprotein translocase SecG subunit. (70 aa)
EHF_0897Putative immunodominant surface protein gp36. (255 aa)
EHF_0917Sodium/hydrogen exchanger family protein; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. (568 aa)
EHF_0924Cytochrome C assembly family protein. (635 aa)
EHF_0936Liporeleasing system, transmembrane, LolC/E family protein. (403 aa)
secFProtein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (293 aa)
EHF_0959Permease family protein. (265 aa)
EHF_0970Cation diffusion facilitator transporter family protein. (306 aa)
EHF_0972ccmB family protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family. (220 aa)
nuoNProton-translocating NADH-quinone oxidoreductase, chain N family protein; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (475 aa)
tatCTwin arginine-targeting protein translocase TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (249 aa)
EHF_0509acrB/AcrD/AcrF family protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1032 aa)
EHF_0513Integral membrane TerC family protein. (219 aa)
nuoENADH-quinone oxidoreductase, E subunit. (181 aa)
nuoHNADH-ubiquinone oxidoreductase chain 1; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. (367 aa)
EHF_0565Cytochrome C biogenesis family protein; Possible subunit of a heme lyase. (133 aa)
EHF_0595Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1043 aa)
lepBSignal peptidase I; Belongs to the peptidase S26 family. (235 aa)
nuoINADH-quinone oxidoreductase, chain I family protein; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (143 aa)
lepAGTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (597 aa)
EHF_0675Hypothetical protein. (75 aa)
Your Current Organism:
Ehrlichia sp. HF
NCBI taxonomy Id: 391036
Other names: E. sp. HF
Server load: low (30%) [HD]