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ruvC ruvC EHF_0994 EHF_0994 xseA xseA EHF_0976 EHF_0976 EHF_0975 EHF_0975 EHF_0974 EHF_0974 EHF_0947 EHF_0947 holA holA EHF_0914 EHF_0914 EHF_0911 EHF_0911 EHF_0889 EHF_0889 EHF_0881 EHF_0881 EHF_0878 EHF_0878 pheS pheS sucD sucD sucC sucC EHF_0840 EHF_0840 rplK rplK rplA rplA rpoB rpoB rpoC rpoC pyrD pyrD dnaE1 dnaE1 sdhC sdhC clpX clpX EHF_0754 EHF_0754 EHF_0752 EHF_0752 sucA sucA mutS mutS nadE nadE fabI fabI EHF_0706 EHF_0706 rpoZ rpoZ nuoC nuoC nuoB nuoB uvrA uvrA ribH ribH EHF_0678 EHF_0678 EHF_0670 EHF_0670 dnaG dnaG sigA sigA nuoI nuoI dgt dgt EHF_0593 EHF_0593 EHF_0584 EHF_0584 EHF_0579 EHF_0579 hscB hscB EHF_0560 EHF_0560 nifU nifU pyrB pyrB nuoE nuoE EHF_0537 EHF_0537 nuoK nuoK nuoF nuoF eno eno EHF_0475 EHF_0475 dnaQ dnaQ petB petB carA carA pccA pccA EHF_0421 EHF_0421 EHF_0402 EHF_0402 rnpA rnpA pheT pheT rpoA rpoA EHF_0338 EHF_0338 carB carB EHF_0326 EHF_0326 EHF_0314 EHF_0314 folK folK EHF_0296 EHF_0296 EHF_0294 EHF_0294 EHF_0284 EHF_0284 ruvA ruvA ruvB ruvB sdhA sdhA EHF_0190 EHF_0190 EHF_0179 EHF_0179 thiS thiS hslV hslV hslU hslU dnaN dnaN prs prs EHF_0124 EHF_0124 sucB sucB dnaX dnaX glyQ glyQ glyS glyS
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (156 aa)
EHF_09944Fe-4S binding domain protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (94 aa)
xseAExodeoxyribonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (388 aa)
EHF_0976Flavofamily protein. (183 aa)
EHF_0975Helicase conserved C-terminal domain protein. (680 aa)
EHF_0974NAD dependent epimerase/dehydratase family protein. (320 aa)
EHF_0947Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (402 aa)
holADNA polymerase III, delta subunit. (302 aa)
EHF_0914Transketolase, pyrimidine binding domain protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (332 aa)
EHF_0911Modulator of DNA gyrase family protein. (477 aa)
EHF_0889Phage integrase family protein; Belongs to the 'phage' integrase family. (309 aa)
EHF_0881NADH-Ubiquinone/plastoquinone (complex I), various chains family protein. (491 aa)
EHF_0878Hypothetical protein. (97 aa)
pheSphenylalanine--tRNA ligase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (347 aa)
sucDsuccinate-CoA ligase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (295 aa)
sucCsuccinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (387 aa)
EHF_0840Metallo-beta-lactamase superfamily protein. (540 aa)
rplKRibosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (147 aa)
rplARibosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (220 aa)
rpoBDNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1380 aa)
rpoCDNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1410 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (350 aa)
dnaE1DNA polymerase III subunit alpha. (1120 aa)
sdhCSuccinate dehydrogenase, cytochrome b556 subunit. (128 aa)
clpXATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (406 aa)
EHF_0754uvrD-like helicase C-terminal domain protein. (194 aa)
EHF_0752uvrD/REP helicase N-terminal domain protein. (639 aa)
sucAOxoglutarate dehydrogenase (succinyl-transferring), E1 component. (912 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (804 aa)
nadENAD+ synthetase. (505 aa)
fabIEnoyl-[acyl-carrier-protein] reductase. (266 aa)
EHF_0706ATPase associated with various cellular activities family protein. (295 aa)
rpoZDNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (140 aa)
nuoCNADH-quinone oxidoreductase, subunit C; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 30 kDa subunit family. (192 aa)
nuoBNADH-quinone oxidoreductase, B subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (177 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (959 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (148 aa)
EHF_0678Inositol monophosphatase family protein. (254 aa)
EHF_0670Ribonucleotide reductase, small chain family protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (327 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (588 aa)
sigARNA polymerase sigma factor rpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (622 aa)
nuoINADH-quinone oxidoreductase, chain I family protein; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (143 aa)
dgtdGTPase family protein; Belongs to the dGTPase family. Type 2 subfamily. (397 aa)
EHF_0593Terminase-like family protein. (469 aa)
EHF_0584RNA polymerase sigma factor, sigma-70 family protein. (295 aa)
EHF_0579Modulator of DNA gyrase family protein. (448 aa)
hscBfe-S protein assembly co-chaperone HscB. (145 aa)
EHF_0560Iron-sulfur cluster assembly accessory family protein; Belongs to the HesB/IscA family. (143 aa)
nifUnifU-like protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. (137 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (298 aa)
nuoENADH-quinone oxidoreductase, E subunit. (181 aa)
EHF_0537Carboxyl transferase domain protein. (510 aa)
nuoKNADH-ubiquinone/plastoquinone oxidoreductase chain 4L family protein; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (108 aa)
nuoFNADH oxidoreductase (quinone), F subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (420 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (421 aa)
EHF_0475Sigma-54 interaction domain protein. (500 aa)
dnaQDNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (242 aa)
petBCytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (377 aa)
carACarbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (374 aa)
pccApropionyl-CoA carboxylase, alpha subunit. (656 aa)
EHF_0421Putative 3'-5' exonuclease related to the exonuclease domain of PolB family protein. (275 aa)
EHF_0402Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (595 aa)
rnpARibonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (119 aa)
pheTphenylalanine--tRNA ligase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (788 aa)
rpoADNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (372 aa)
EHF_0338uvrD/REP helicase N-terminal domain protein. (857 aa)
carBCarbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1023 aa)
EHF_0326DNA / pantothenate metabolism flavofamily protein. (212 aa)
EHF_0314DNA repair RadC family protein; Belongs to the UPF0758 family. (230 aa)
folK2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase. (176 aa)
EHF_0296Phage integrase family protein; Belongs to the 'phage' integrase family. (310 aa)
EHF_0294NAD-dependent glycerol-3-phosphate dehydrogenase family protein; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (308 aa)
EHF_0284NADH-Ubiquinone/plastoquinone (complex I), various chains family protein. (494 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (190 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (329 aa)
sdhASuccinate dehydrogenase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (598 aa)
EHF_0190Exonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (62 aa)
EHF_0179Thiazole biosynthesis ThiG family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (261 aa)
thiSThiamine biosynthesis protein ThiS. (68 aa)
hslVATP-dependent protease HslVU, peptidase subunit; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. (189 aa)
hslUATP-dependent protease HslVU, ATPase subunit; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. (492 aa)
dnaNDNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (375 aa)
prsRibose-phosphate diphosphokinase family protein. (318 aa)
EHF_0124Peptidase M16 inactive domain protein. (451 aa)
sucBDihydrolipoyllysine-residue succinyltransferase, E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (400 aa)
dnaXDNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (500 aa)
glyQglycine--tRNA ligase, alpha subunit. (280 aa)
glySglycine--tRNA ligase, beta subunit. (703 aa)
Your Current Organism:
Ehrlichia sp. HF
NCBI taxonomy Id: 391036
Other names: E. sp. HF
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