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asd asd gap gap icd icd sucB sucB acnA acnA prs prs EHF_0167 EHF_0167 gltX gltX pdhA pdhA glyA glyA sdhA sdhA EHF_0272 EHF_0272 folD folD ppdK ppdK glpX glpX EHF_0320 EHF_0320 fumC fumC dapB dapB tkt tkt EHF_0424 EHF_0424 lysA lysA pccA pccA gpmI gpmI EHF_0453 EHF_0453 eno eno fsa fsa EHF_0528 EHF_0528 EHF_0537 EHF_0537 gltX-2 gltX-2 rpiB rpiB mdh mdh tpiA tpiA EHF_0622 EHF_0622 hemC hemC EHF_0674 EHF_0674 hemB hemB dapA dapA sucA sucA argD argD sdhD sdhD sdhC sdhC pdxH pdxH sucC sucC sucD sucD EHF_0854 EHF_0854 EHF_0860 EHF_0860 tme tme EHF_0914 EHF_0914 dapE dapE gltA gltA EHF_0947 EHF_0947 glnA glnA rpe rpe dapD dapD pgk pgk dapF dapF
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Your Input:
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (336 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase, type I; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
icdIsocitrate dehydrogenase. (482 aa)
sucBDihydrolipoyllysine-residue succinyltransferase, E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (400 aa)
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (877 aa)
prsRibose-phosphate diphosphokinase family protein. (318 aa)
EHF_0167Aspartate kinase domain protein; Belongs to the aspartokinase family. (417 aa)
gltXglutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (443 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (319 aa)
glyASerine hydroxymethyltransferase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (421 aa)
sdhASuccinate dehydrogenase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (598 aa)
EHF_0272Succinate dehydrogenase and fumarate reductase iron-sulfur family protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (258 aa)
folDTetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (298 aa)
ppdKPyruvate, phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (875 aa)
glpXFructose-1,6-bisphosphatase, class II. (307 aa)
EHF_0320Dioxygenase family protein. (224 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (267 aa)
tktTransketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (663 aa)
EHF_0424uroporphyrinogen-III synthase HemD family protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (229 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (423 aa)
pccApropionyl-CoA carboxylase, alpha subunit. (656 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (501 aa)
EHF_0453Dihydrolipoyl dehydrogenase. (465 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (421 aa)
fsaFructose-6-phosphate aldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (221 aa)
EHF_05283-hydroxyacyl-CoA dehydrogenase, C-terminal domain protein. (401 aa)
EHF_0537Carboxyl transferase domain protein. (510 aa)
gltX-2glutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (469 aa)
rpiBRibose 5-phosphate isomerase B. (146 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (313 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (240 aa)
EHF_0622Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (210 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (298 aa)
EHF_0674Bacterial NAD-glutamate dehydrogenase family protein. (1583 aa)
hemBDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (331 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (314 aa)
sucAOxoglutarate dehydrogenase (succinyl-transferring), E1 component. (912 aa)
argDTransaminase, acetylornithine/succinylornithine family protein. (390 aa)
sdhDSuccinate dehydrogenase, hydrophobic membrane anchor protein. (118 aa)
sdhCSuccinate dehydrogenase, cytochrome b556 subunit. (128 aa)
pdxHPyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (197 aa)
sucCsuccinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (387 aa)
sucDsuccinate-CoA ligase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (295 aa)
EHF_0854Glutamine synthetase, catalytic domain protein. (271 aa)
EHF_0860Dihydrolipoyl dehydrogenase. (471 aa)
tmeNADP-dependent malic enzyme. (759 aa)
EHF_0914Transketolase, pyrimidine binding domain protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (332 aa)
dapESuccinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (381 aa)
gltACitrate (Si)-synthase; Belongs to the citrate synthase family. (416 aa)
EHF_0947Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (402 aa)
glnAGlutamine synthetase, type I. (469 aa)
rpeRibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (270 aa)
pgkPhosphoglycerate kinase family protein; Belongs to the phosphoglycerate kinase family. (394 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (268 aa)
Your Current Organism:
Ehrlichia sp. HF
NCBI taxonomy Id: 391036
Other names: E. sp. HF
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