STRINGSTRING
Sare_0054 Sare_0054 leuA leuA Sare_0265 Sare_0265 Sare_0266 Sare_0266 Sare_0305 Sare_0305 Sare_0361 Sare_0361 Sare_0418 Sare_0418 Sare_0486 Sare_0486 Sare_0510 Sare_0510 Sare_0567 Sare_0567 Sare_0588 Sare_0588 Sare_0777 Sare_0777 Sare_0865 Sare_0865 Sare_1100 Sare_1100 Sare_1117 Sare_1117 ilvD ilvD Sare_1123 Sare_1123 Sare_1124 Sare_1124 ilvC ilvC Sare_1126 Sare_1126 Sare_1129 Sare_1129 Sare_1130 Sare_1130 Sare_1133 Sare_1133 leuC leuC leuD leuD Sare_1274 Sare_1274 dapB dapB dapA dapA dapF dapF Sare_1822 Sare_1822 aroC aroC aroK aroK aroB aroB aroQ-2 aroQ-2 Sare_1872 Sare_1872 hisG hisG Sare_2067 Sare_2067 Sare_2452 Sare_2452 Sare_2453 Sare_2453 Sare_2513 Sare_2513 Sare_2955 Sare_2955 Sare_3058 Sare_3058 Sare_3182 Sare_3182 aroA aroA Sare_3238 Sare_3238 trpA trpA trpB trpB trpC trpC trpE trpE hisI hisI hisF hisF hisA hisA hisH hisH hisB hisB hisC hisC hisD hisD Sare_3482 Sare_3482 Sare_3483 Sare_3483 trpD trpD Sare_3922 Sare_3922 asd asd Sare_3950 Sare_3950 thrB thrB Sare_4032 Sare_4032 Sare_4033 Sare_4033 lysA lysA aroA-2 aroA-2 Sare_4134 Sare_4134 dapD dapD Sare_4139 Sare_4139 Sare_4208 Sare_4208 Sare_4251 Sare_4251 Sare_4432 Sare_4432 Sare_4527 Sare_4527 pat pat pheA pheA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Sare_0054TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: stp:Strop_0049 glutamine amidotransferase of anthranilate synthase. (216 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (584 aa)
Sare_0265KEGG: stp:Strop_0226 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (421 aa)
Sare_0266KEGG: stp:Strop_0227 aspartate-semialdehyde dehydrogenase; TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase NAD - binding; Semialdehyde dehydrogenase dimerisation region; Belongs to the aspartate-semialdehyde dehydrogenase family. (353 aa)
Sare_0305TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: stp:Strop_0263 threonine synthase. (428 aa)
Sare_0361Hypothetical protein; KEGG: sen:SACE_0282 aspartate kinase. (171 aa)
Sare_0418TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); HAD-superfamily subfamily IB hydrolase, TIGR01490; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: stp:Strop_0348 HAD-superfamily subfamily IB hydrolase, TIGR01490. (312 aa)
Sare_0486PFAM: Orn/DAP/Arg decarboxylase 2; KEGG: atc:AGR_C_3079 hypothetical protein. (417 aa)
Sare_0510Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (375 aa)
Sare_0567PFAM: D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: mka:MK0297 predicted dehydrogenase related to phosphoglycerate dehydrogenase. (345 aa)
Sare_0588ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (217 aa)
Sare_0777Amidohydrolase; KEGG: stp:Strop_0833 amidohydrolase; TIGRFAM: amidohydrolase; PFAM: peptidase M20. (467 aa)
Sare_0865TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; amino acid-binding ACT domain protein; KEGG: stp:Strop_0922 threonine dehydratase. (406 aa)
Sare_1100PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: stp:Strop_1207 thiamine pyrophosphate enzyme domain protein TPP-binding; Belongs to the TPP enzyme family. (540 aa)
Sare_1117PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: stp:Strop_1225 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (306 aa)
ilvDKEGG: stp:Strop_1231 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (615 aa)
Sare_1123TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: stp:Strop_1233 acetolactate synthase, large subunit, biosynthetic type. (629 aa)
Sare_1124TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: stp:Strop_1234 acetolactate synthase, small subunit. (171 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa)
Sare_1126TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: stp:Strop_1236 D-3-phosphoglycerate dehydrogenase. (531 aa)
Sare_1129PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: stp:Strop_1239 3-isopropylmalate dehydrogenase. (343 aa)
Sare_1130TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV; KEGG: stp:Strop_1240 branched-chain amino acid aminotransferase. (365 aa)
Sare_1133TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: stp:Strop_1243 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (527 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (481 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (195 aa)
Sare_1274PFAM: UBA/THIF-type NAD/FAD binding protein; Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: fal:FRAAL0918 aminoquinate/shkimate dehydrogenase. (270 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (256 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (308 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (278 aa)
Sare_1822TIGRFAM: shikimate-5-dehydrogenase; PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: stp:Strop_1831 shikimate-5-dehydrogenase; Belongs to the shikimate dehydrogenase family. (275 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (402 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (167 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (357 aa)
aroQ-23-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (143 aa)
Sare_1872PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: stp:Strop_1879 phosphoribosyl-ATP pyrophosphohydrolase; Belongs to the PRA-PH family. (100 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (294 aa)
Sare_2067PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: sma:SAV1372 acetolactate synthase; Belongs to the TPP enzyme family. (568 aa)
Sare_2452PFAM: aminotransferase class I and II; KEGG: stp:Strop_2329 aminotransferase, class I and II. (386 aa)
Sare_2453Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; KEGG: stp:Strop_2330 helix-turn-helix domain protein. (175 aa)
Sare_2513PFAM: Chorismate binding-like; KEGG: stp:Strop_2375 anthranilate synthase component I and chorismate binding protein. (408 aa)
Sare_2955PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: bbr:BB0923 putative acetolactate synthase large subunit; Belongs to the TPP enzyme family. (565 aa)
Sare_3058PFAM: Orn/DAP/Arg decarboxylase 2; KEGG: stp:Strop_0681 Orn/DAP/Arg decarboxylase 2; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (418 aa)
Sare_3182PFAM: glutamine amidotransferase class-I; Chorismate binding-like; KEGG: stp:Strop_2960 glutamine amidotransferase class-I. (651 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (414 aa)
Sare_3238PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mxa:MXAN_3857 pyruvate dehydrogenase; Belongs to the TPP enzyme family. (614 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (410 aa)
trpCPFAM: Indole-3-glycerol phosphate synthase; KEGG: stp:Strop_3172 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (267 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (517 aa)
hisIPhosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (147 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (255 aa)
hisAKEGG: stp:Strop_3190 bifunctional HisA/TrpF protein; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis protein. (241 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (210 aa)
hisBPFAM: imidazoleglycerol-phosphate dehydratase; KEGG: stp:Strop_3194 imidazoleglycerol-phosphate dehydratase. (203 aa)
hisCTIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: stp:Strop_3195 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (358 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (440 aa)
Sare_3482Threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: stp:Strop_3255 threonine aldolase. (343 aa)
Sare_3483KEGG: stp:Strop_3256 phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase class II; Belongs to the class-II DAHP synthase family. (468 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (353 aa)
Sare_3922PFAM: aminotransferase class I and II; KEGG: stp:Strop_3547 aminotransferase, class I and II. (366 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (341 aa)
Sare_3950Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (362 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (314 aa)
Sare_4032Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (349 aa)
Sare_4033PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; KEGG: stp:Strop_3651 homoserine dehydrogenase. (437 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (470 aa)
aroA-23-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (433 aa)
Sare_4134TIGRFAM: succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: stp:Strop_3752 succinyl-diaminopimelate desuccinylase. (357 aa)
dapDConserved hypothetical protein; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (319 aa)
Sare_4139PFAM: Prephenate dehydrogenase; 6-phosphogluconate dehydrogenase NAD-binding; KEGG: stp:Strop_3757 prephenate dehydrogenase. (348 aa)
Sare_4208TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; KEGG: stp:Strop_3818 chorismate mutase. (112 aa)
Sare_4251Aminotransferase class I and II; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class I and II; KEGG: stp:Strop_3861 aminotransferase, class I and II. (397 aa)
Sare_4432TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); HAD-superfamily subfamily IB hydrolase, TIGR01490; KEGG: stp:Strop_4041 HAD-superfamily subfamily IB hydrolase, TIGR01490. (270 aa)
Sare_4527PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: stp:Strop_4106 pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (314 aa)
patHistidinol-phosphate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (367 aa)
pheAPFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: stp:Strop_4522 prephenate dehydratase. (318 aa)
Your Current Organism:
Salinispora arenicola
NCBI taxonomy Id: 391037
Other names: S. arenicola CNS-205, Salinispora arenicola CNS-205, Salinispora arenicola str. CNS-205, Salinispora arenicola strain CNS-205
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.