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| | Sare_3064 | PFAM: protein of unknown function DUF201; KEGG: sco:SCO6437 hypothetical protein. (441 aa) |
| | Sare_3061 | Pyridoxal-5'-phosphate-dependent protein beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (447 aa) |
| | Sare_3014 | SMART: nucleoside diphosphate kinase; KEGG: stp:Strop_4148 nucleoside diphosphate kinase; Belongs to the NDK family. (326 aa) |
| | Sare_2980 | KEGG: sen:SACE_1035 phosphoribulokinase / uridine kinase family. (250 aa) |
| | Sare_2943 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: aau:AAur_0949 hypothetical protein. (193 aa) |
| | Sare_2937 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; RNA polymerase sigma-G type; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: mlo:mlr2184 probable RNA polymerase sigma subunit; Belongs to the sigma-70 factor family. ECF subfamily. (357 aa) |
| | Sare_2923 | KEGG: stp:Strop_1717 hypothetical protein. (444 aa) |
| | Sare_2917 | Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: stp:Strop_4402 sigma-70 region 2 domain protein; Belongs to the sigma-70 factor family. (381 aa) |
| | Sare_2902 | PFAM: cobalamin synthesis CobW domain protein; KEGG: stp:Strop_4195 cobalamin synthesis CobW domain protein. (427 aa) |
| | Sare_2851 | PFAM: flavoprotein; KEGG: stp:Strop_2580 flavoprotein. (191 aa) |
| | Sare_2797 | KEGG: sen:SACE_4666 hypothetical protein. (137 aa) |
| | cbiM | Cobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (226 aa) |
| | cbiN | Cobalt transport protein; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (105 aa) |
| | Sare_2785 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: stp:Strop_2587 sigma-70, region 4 type 2; Belongs to the sigma-70 factor family. ECF subfamily. (188 aa) |
| | Sare_2750 | KEGG: stp:Strop_2563 hypothetical protein. (132 aa) |
| | Sare_2710 | KEGG: stp:Strop_2528 cobaltochelatase, CobN subunit; TIGRFAM: cobaltochelatase, CobN subunit; PFAM: CobN/magnesium chelatase. (1222 aa) |
| | Sare_2709 | KEGG: stp:Strop_2527 magnesium chelatase; PFAM: magnesium chelatase ChlI subunit; von Willebrand factor type A; ATPase associated with various cellular activities AAA_5; SMART: AAA ATPase. (730 aa) |
| | Sare_2708 | TIGRFAM: cob(I)alamin adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; KEGG: stp:Strop_2526 cob(I)alamin adenosyltransferase. (203 aa) |
| | cobB | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (452 aa) |
| | Sare_2706 | TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: stp:Strop_2524 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. (247 aa) |
| | Sare_2705 | TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: stp:Strop_2523 precorrin-4 C11-methyltransferase. (308 aa) |
| | cbiD | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (380 aa) |
| | Sare_2703 | TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: stp:Strop_2521 precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit. (426 aa) |
| | Sare_2702 | TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; cobalamin (vitamin B12) biosynthesis CbiG protein; KEGG: stp:Strop_2520 precorrin-3B C17-methyltransferase. (574 aa) |
| | Sare_2700 | PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: stp:Strop_2518 precorrin-8X methylmutase CbiC/CobH. (196 aa) |
| | Sare_2699 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: stp:Strop_2517 uroporphyrin-III C-methyltransferase. (550 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA (By similarity). In the N-terminal section; belongs to the AccD/PCCB family. (566 aa) |
| | Sare_2670 | PFAM: dehydrogenase E1 component; KEGG: stp:Strop_2487 dehydrogenase, E1 component. (323 aa) |
| | Sare_2647 | TIGRFAM: pyridoxal kinase; KEGG: stp:Strop_2472 pyridoxal kinase; Belongs to the pyridoxine kinase family. (283 aa) |
| | Sare_2646 | Putative nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (450 aa) |
| | Sare_2614 | PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein; KEGG: stp:Strop_3014 cobalamin synthesis protein, P47K. (410 aa) |
| | Sare_2549 | PFAM: GCN5-related N-acetyltransferase; KEGG: stp:Strop_2400 hypothetical protein. (200 aa) |
| | Sare_2513 | PFAM: Chorismate binding-like; KEGG: stp:Strop_2375 anthranilate synthase component I and chorismate binding protein. (408 aa) |
| | Sare_2486 | PFAM: thymidine kinase; KEGG: stp:Strop_2343 thymidine kinase. (234 aa) |
| | Sare_2441 | KEGG: mav:MAV_0635 hypothetical protein. (133 aa) |
| | Sare_2338 | PFAM: dTDP-4-dehydrorhamnose 35-epimerase related; KEGG: sma:SAV949 dTDP-4-keto-6-deoxyhexose 3,5-epimerase. (200 aa) |
| | Sare_2294 | Anti-sigma-factor antagonist; TIGRFAM: RNA polymerase sigma-70; RNA polymerase sigma-B/F/G type; PFAM: Sulfate transporter/antisigma-factor antagonist STAS; sigma-70 region 3 domain protein; sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: stp:Strop_2142 sigma-70 region 2 domain protein. (374 aa) |
| | Sare_2238 | PFAM: dehydrogenase E1 component; KEGG: stp:Strop_2097 pyruvate dehydrogenase (acetyl-transferring). (382 aa) |
| | Sare_2236 | PFAM: DNA primase small subunit; KEGG: stp:Strop_2095 DNA primase, small subunit. (323 aa) |
| | Sare_2148 | PFAM: protein of unknown function DUF201; KEGG: plu:plu0116 hypothetical protein. (414 aa) |
| | Sare_2144 | PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; KEGG: sco:SCO6898 carboxylase. (416 aa) |
| | Sare_2131 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; RNA polymerase sigma-E type; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: ace:Acel_1494 RNA polymerase, sigma-24 subunit, ECF subfamily; Belongs to the sigma-70 factor family. ECF subfamily. (166 aa) |
| | Sare_2018 | PFAM: dTDP-4-dehydrorhamnose 35-epimerase related; KEGG: sen:SACE_0714 dTDP-4-deoxyglucose 3,5-epimerase. (187 aa) |
| | Sare_2017 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (297 aa) |
| | Sare_1999 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase. (133 aa) |
| | tmk | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (227 aa) |
| | Sare_1926 | PFAM: Bifunctional DNA primase/polymerase; KEGG: stp:Strop_0062 hypothetical protein. (377 aa) |
| | Sare_1924 | KEGG: pna:Pnap_0963 hypothetical protein. (616 aa) |
| | cmk | KEGG: stp:Strop_1929 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region. (226 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (581 aa) |
| | Sare_1905 | PFAM: Thiamin pyrophosphokinase catalytic region; KEGG: stp:Strop_1914 thiamin pyrophosphokinase, catalytic region. (392 aa) |
| | nadK-2 | NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (295 aa) |
| | Sare_1859 | KEGG: stp:Strop_1866 hypothetical protein. (327 aa) |
| | priA | Conserved hypothetical protein; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (625 aa) |
| | Sare_1856 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (404 aa) |
| | rpoZ | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (88 aa) |
| | Sare_1854 | SMART: guanylate kinase/L-type calcium channel region; KEGG: stp:Strop_1861 guanylate kinase/L-type calcium channel region. (177 aa) |
| | pyrF | TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: stp:Strop_1859 orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (278 aa) |
| | pyrD | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (338 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; KEGG: stp:Strop_1856 carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1115 aa) |
| | carA | KEGG: stp:Strop_1855 carbamoyl-phosphate synthase, small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (386 aa) |
| | pyrC | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (425 aa) |
| | pyrB | KEGG: stp:Strop_1853 aspartate carbamoyltransferase; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (308 aa) |
| | nusB | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (136 aa) |
| | aroQ-2 | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (143 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (357 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (167 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (402 aa) |
| | Sare_1822 | TIGRFAM: shikimate-5-dehydrogenase; PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: stp:Strop_1831 shikimate-5-dehydrogenase; Belongs to the shikimate dehydrogenase family. (275 aa) |
| | Sare_1805 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (827 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (188 aa) |
| | Sare_1784 | KEGG: stp:Strop_1798 DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; DNA polymerase III alpha subunit; SMART: phosphoesterase PHP domain protein. (1177 aa) |
| | pdxT | SNO glutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (201 aa) |
| | pdxS | Pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (306 aa) |
| | Sare_1750 | Cytidyltransferase-related domain; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (502 aa) |
| | nadK | NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (309 aa) |
| | Sare_1643 | PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: stp:Strop_1658 adenylyl cyclase class-3/4/guanylyl cyclase. (536 aa) |
| | Sare_1629 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: stp:Strop_1705 bifunctional deaminase-reductase domain protein. (185 aa) |
| | Sare_1493 | Hypothetical protein. (98 aa) |
| | Sare_1486 | TIGRFAM: DNA polymerase LigD polymerase domain; PFAM: DNA primase small subunit; KEGG: stp:Strop_1543 DNA primase, small subunit. (341 aa) |
| | Sare_1479 | PFAM: GCN5-related N-acetyltransferase; KEGG: stp:Strop_1537 GCN5-related N-acetyltransferase. (149 aa) |
| | Sare_1476 | PFAM: Chlorite dismutase; KEGG: stp:Strop_1534 chlorite dismutase. (233 aa) |
| | Sare_1475 | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (469 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (365 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (660 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (167 aa) |
| | sigA | RNA polymerase, sigma 70 subunit, RpoD family; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (532 aa) |
| | Sare_1424 | RNA polymerase, sigma 70 subunit, RpoD family; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (328 aa) |
| | Sare_1356 | PFAM: CinA domain protein; KEGG: stp:Strop_1398 CinA domain protein; Belongs to the CinA family. (177 aa) |
| | thyX | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (247 aa) |
| | Sare_1337 | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; KEGG: stp:Strop_1379 riboflavin biosynthesis protein RibF; Belongs to the ribF family. (309 aa) |
| | nusA | NusA antitermination factor; Participates in both transcription termination and antitermination. (347 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (143 aa) |
| | Sare_1274 | PFAM: UBA/THIF-type NAD/FAD binding protein; Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: fal:FRAAL0918 aminoquinate/shkimate dehydrogenase. (270 aa) |
| | Sare_1254 | 3-deoxy-7-phosphoheptulonate synthase; PFAM: DAHP synthetase class II; KEGG: sen:SACE_1708 phospho-2-dehydro-3-deoxyheptonate aldolase; Belongs to the class-II DAHP synthase family. (446 aa) |
| | Sare_1253 | PFAM: 3-dehydroquinate synthase; KEGG: sen:SACE_2868 3-dehydroquinate synthase. (353 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (251 aa) |
| | Sare_1212 | KEGG: sen:SACE_7030 possible phiRv2 prophage protein. (410 aa) |
| | Sare_1206 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: stp:Strop_2683 bifunctional deaminase-reductase domain protein. (221 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (158 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (317 aa) |
| | Sare_1127 | KEGG: stp:Strop_1237 hypothetical protein. (96 aa) |
| | Sare_1101 | KEGG: stp:Strop_1208 hypothetical protein. (135 aa) |
| | Sare_1071 | dTDP-4-dehydrorhamnose reductase; PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; dTDP-4-dehydrorhamnose reductase; KEGG: stp:Strop_1177 dTDP-4-dehydrorhamnose reductase. (279 aa) |
| | Sare_1007 | KEGG: stp:Strop_1117 hypothetical protein. (130 aa) |
| | Sare_1006 | PFAM: cobalamin (vitamin B12) biosynthesis CbiM protein; KEGG: stp:Strop_1116 cobalamin (vitamin B12) biosynthesis CbiM protein. (238 aa) |
| | Sare_0986 | Putative nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (428 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (192 aa) |
| | Sare_0002 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (377 aa) |
| | folD1 | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (279 aa) |
| | Sare_0079 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; RNA polymerase sigma-G type; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: rha:RHA1_ro05361 sigma factor, sigma 70 type, group 4; Belongs to the sigma-70 factor family. ECF subfamily. (338 aa) |
| | Sare_0083 | PFAM: phosphoribosyltransferase; KEGG: stp:Strop_0086 phosphoribosyltransferase. (183 aa) |
| | Sare_0109 | PFAM: dehydrogenase E1 component; KEGG: stp:Strop_0109 pyruvate dehydrogenase (acetyl-transferring). (391 aa) |
| | pyrE | Phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (179 aa) |
| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa) |
| | purD | KEGG: stp:Strop_0134 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; Belongs to the GARS family. (416 aa) |
| | Sare_0154 | KEGG: stp:Strop_0147 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (474 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (87 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (226 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (849 aa) |
| | Sare_0160 | KEGG: rso:RSc1273 putative lipoprotein. (251 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (526 aa) |
| | purM | KEGG: stp:Strop_0155 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein. (381 aa) |
| | Sare_0252 | KEGG: stp:Strop_0213 DNA polymerase III, subunits gamma and tau; TIGRFAM: DNA polymerase III, subunits gamma and tau; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase. (834 aa) |
| | Sare_0272 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; RNA polymerase sigma-70 ECF type; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: stp:Strop_0232 RNA polymerase, sigma-24 subunit, ECF subfamily; Belongs to the sigma-70 factor family. (314 aa) |
| | Sare_0373 | Domain of unknown function DUF1794; May play a role in the intracellular transport of hydrophobic ligands. (196 aa) |
| | Sare_0420 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; RNA polymerase sigma-X type; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: stp:Strop_0350 RNA polymerase, sigma-24 subunit, ECF subfamily; Belongs to the sigma-70 factor family. ECF subfamily. (310 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (455 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (322 aa) |
| | Sare_0428 | Uroporphyrinogen III synthase HEM4; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; KEGG: stp:Strop_0358 uroporphyrinogen III synthase HEM4. (526 aa) |
| | Sare_0429 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: stp:Strop_0359 porphobilinogen synthase; Belongs to the ALAD family. (327 aa) |
| | Sare_0485 | PFAM: protein of unknown function DUF201; KEGG: cac:CA_P0138 hypothetical protein. (453 aa) |
| | Sare_0510 | Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (375 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (221 aa) |
| | Sare_0565 | PFAM: MGS domain protein; KEGG: rrs:RoseRS_0206 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (190 aa) |
| | purA-2 | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (422 aa) |
| | Sare_0568 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: rxy:Rxyl_2365 RNA polymerase, sigma-24 subunit, ECF subfamily; Belongs to the sigma-70 factor family. (199 aa) |
| | Sare_0569 | PFAM: aminotransferase class-III; KEGG: rpd:RPD_2366 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (435 aa) |
| | Sare_0573 | PFAM: phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; KEGG: rha:RHA1_ro08658 possible dehydrogenase. (420 aa) |
| | Sare_0578 | PFAM: SAICAR synthetase; KEGG: hal:VNG1939G phosphoribosylaminoimidazole-succinocarboxamide synthase. (322 aa) |
| | Sare_0580 | KEGG: sen:SACE_7153 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (476 aa) |
| | Sare_0582 | PFAM: SAICAR synthetase; KEGG: mth:MTH170 phosphoribosylaminoimidazole-succinocarboxamide synthase. (236 aa) |
| | Sare_0649 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (289 aa) |
| | Sare_0655 | Transcriptional regulator, PaaX family; PFAM: PaaX domain protein; PaaX domain protein domain; KEGG: stp:Strop_0708 transcriptional regulator, PaaX family. (272 aa) |
| | Sare_0696 | PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; KEGG: stp:Strop_1607 metal-dependent phosphohydrolase, HD sub domain. (193 aa) |
| | Sare_0717 | KEGG: stp:Strop_0775 hypothetical protein. (460 aa) |
| | Sare_0719 | PFAM: 4'-phosphopantetheinyl transferase; KEGG: stp:Strop_0777 4'-phosphopantetheinyl transferase; Belongs to the P-Pant transferase superfamily. (347 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (512 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa) |
| | add | KEGG: stp:Strop_0815 adenosine deaminase; TIGRFAM: adenosine deaminase; PFAM: adenosine/AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (364 aa) |
| | Sare_0773 | TIGRFAM: uracil phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: stp:Strop_0829 uracil phosphoribosyltransferase; Belongs to the UPRTase family. (210 aa) |
| | Sare_0791 | KEGG: stp:Strop_0848 IMP dehydrogenase family protein; TIGRFAM: IMP dehydrogenase family protein; PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase. (479 aa) |
| | Sare_0800 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; RNA polymerase sigma-E type; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: stp:Strop_0854 sigma-70, region 4 type 2; Belongs to the sigma-70 factor family. ECF subfamily. (166 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (393 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (163 aa) |
| | Sare_0875 | PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; KEGG: stp:Strop_0933 UDP-glucose 6-dehydrogenase. (475 aa) |
| | Sare_0879 | TIGRFAM: acetoacetyl-CoA synthase; PFAM: AMP-dependent synthetase and ligase; KEGG: stp:Strop_0937 acetoacetyl-CoA synthase. (664 aa) |
| | Sare_0902 | TIGRFAM: mannose-6-phosphate isomerase, class I; PFAM: mannose-6-phosphate isomerase type I; KEGG: stp:Strop_0965 mannose-6-phosphate isomerase, class I. (387 aa) |
| | Sare_0922 | Methylthioadenosine phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. (267 aa) |
| | Sare_0923 | PFAM: protein of unknown function DUF179; KEGG: stp:Strop_0987 protein of unknown function DUF179; Belongs to the UPF0301 (AlgH) family. (196 aa) |
| | Sare_0952 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; RNA polymerase sigma-G type; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: stp:Strop_3152 sigma-70 region 2 domain protein; Belongs to the sigma-70 factor family. ECF subfamily. (331 aa) |
| | Sare_0956 | Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: stp:Strop_2313 sigma-70 region 2 domain protein; Belongs to the sigma-70 factor family. (366 aa) |
| | Sare_0985 | PFAM: isochorismatase hydrolase; KEGG: stp:Strop_1096 isochorismatase hydrolase. (193 aa) |
| | Sare_5095 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: stp:Strop_4577 sigma-70 region 2 domain protein; Belongs to the sigma-70 factor family. ECF subfamily. (246 aa) |
| | Sare_5089 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; RNA polymerase sigma-E type; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: stp:Strop_4572 sigma-70, region 4 type 2; Belongs to the sigma-70 factor family. ECF subfamily. (187 aa) |
| | Sare_5064 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (844 aa) |
| | pheA | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: stp:Strop_4522 prephenate dehydratase. (318 aa) |
| | Sare_5014 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: stp:Strop_4502 sigma-70, region 4 type 2; Belongs to the sigma-70 factor family. ECF subfamily. (184 aa) |
| | kmo-2 | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily. (454 aa) |
| | Sare_4876 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (350 aa) |
| | Sare_4787 | Adenylate/guanylate cyclase with TPR repeats; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein; KEGG: stp:Strop_4346 adenylyl cyclase class-3/4/guanylyl cyclase. (1190 aa) |
| | Sare_4745 | KEGG: stp:Strop_4309 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (190 aa) |
| | folE | PFAM: GTP cyclohydrolase I; KEGG: stp:Strop_4307 GTP cyclohydrolase I. (219 aa) |
| | Sare_4732 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (291 aa) |
| | Sare_4730 | TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; KEGG: stp:Strop_4295 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. (175 aa) |
| | Sare_4731 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (120 aa) |
| | Sare_4715 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (572 aa) |
| | Sare_4714 | TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; KEGG: stp:Strop_4279 nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (298 aa) |
| | coaX | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (252 aa) |
| | Sare_4692 | Transcriptional regulator, CarD family; PFAM: transcription factor CarD; KEGG: stp:Strop_4262 transcription factor CarD. (161 aa) |
| | Sare_4666 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: nfa:nfa45840 putative sigma factor; Belongs to the sigma-70 factor family. ECF subfamily. (170 aa) |
| | Sare_4650 | Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: stp:Strop_4217 sigma-70 region 2 domain protein; Belongs to the sigma-70 factor family. (409 aa) |
| | Sare_4631 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: stp:Strop_3142 bifunctional deaminase-reductase domain protein. (192 aa) |
| | Sare_4627 | PFAM: protein of unknown function DUF1486; KEGG: sco:SCO4364 hypothetical protein. (125 aa) |
| | Sare_4554 | TIGRFAM: methyltransferase FkbM family; KEGG: sma:SAV3646 methyltransferase. (263 aa) |
| | hemL | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: stp:Strop_4100 glutamate-1-semialdehyde-2,1-aminomutase. (444 aa) |
| | Sare_4446 | Transcriptional regulator, LuxR family; TIGRFAM: RNA polymerase sigma-70; PFAM: regulatory protein LuxR; sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: kra:Krad_1800 RNA polymerase, sigma-24 subunit, ECF subfamily; Belongs to the sigma-70 factor family. ECF subfamily. (165 aa) |
| | acsA | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (661 aa) |
| | tmk-3 | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (703 aa) |
| | Sare_4403 | KEGG: stp:Strop_4022 DNA polymerase III, delta prime subunit; TIGRFAM: DNA polymerase III, delta prime subunit; SMART: AAA ATPase. (424 aa) |
| | Sare_4360 | rfaE bifunctional protein; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (643 aa) |
| | Sare_4351 | TIGRFAM: DNA polymerase LigD polymerase domain; PFAM: DNA primase small subunit; KEGG: stp:Strop_3967 DNA primase, small subunit. (303 aa) |
| | nusG | NusG antitermination factor; Participates in transcription elongation, termination and antitermination. (242 aa) |
| | rpoB | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1143 aa) |
| | rpoC | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1297 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa) |
| | rpoA | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (340 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (208 aa) |
| | Sare_4279 | TIGRFAM: glycine oxidase ThiO; PFAM: FAD dependent oxidoreductase; KEGG: stp:Strop_3888 glycine oxidase ThiO. (398 aa) |
| | Sare_4278 | TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: stp:Strop_3887 thiamine biosynthesis protein ThiS. (66 aa) |
| | thiG | Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (259 aa) |
| | Sare_4276 | PFAM: thiamine monophosphate synthase; KEGG: stp:Strop_3885 thiamine monophosphate synthase. (232 aa) |
| | Sare_4275 | KEGG: stp:Strop_3884 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. (261 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (530 aa) |
| | Sare_4262 | PFAM: transcriptional regulator domain protein; Uroporphyrinogen III synthase HEM4; KEGG: stp:Strop_3871 uroporphyrinogen III synthase HEM4. (362 aa) |
| | Sare_4233 | KEGG: stp:Strop_3843 hypothetical protein. (411 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (520 aa) |
| | Sare_4226 | TIGRFAM: IMP dehydrogenase family protein; KEGG: stp:Strop_3836 IMP dehydrogenase family protein. (387 aa) |
| | guaA | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (517 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (206 aa) |
| | purH | KEGG: stp:Strop_3806 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. (522 aa) |
| | folD2 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa) |
| | Sare_4153 | KEGG: stp:Strop_3771 hypothetical protein. (101 aa) |
| | Sare_4139 | PFAM: Prephenate dehydrogenase; 6-phosphogluconate dehydrogenase NAD-binding; KEGG: stp:Strop_3757 prephenate dehydrogenase. (348 aa) |
| | Sare_4137 | KEGG: stp:Strop_3755 hypothetical protein. (215 aa) |
| | Sare_4109 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: stp:Strop_3728 bifunctional deaminase-reductase domain protein. (195 aa) |
| | purC | KEGG: stp:Strop_3726 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (277 aa) |
| | Sare_4106 | KEGG: stp:Strop_3725 ribose-phosphate pyrophosphokinase; TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase. (312 aa) |
| | aroA-2 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (433 aa) |
| | Sare_4095 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: stp:Strop_3714 sigma-70 region 2 domain protein; Belongs to the sigma-70 factor family. ECF subfamily. (268 aa) |
| | Sare_4082 | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: stp:Strop_3702 cobalamin (vitamin B12) biosynthesis CbiX protein. (250 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (375 aa) |
| | Sare_4072 | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (689 aa) |
| | Sare_4055 | PFAM: transcriptional coactivator/pterin dehydratase; KEGG: ace:Acel_1862 transcriptional coactivator/pterin dehydratase. (97 aa) |
| | Sare_4039 | TIGRFAM: DNA polymerase LigD polymerase domain; PFAM: DNA primase small subunit; KEGG: stp:Strop_3663 DNA primase, small subunit. (319 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (688 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (265 aa) |
| | atpE | H+transporting two-sector ATPase C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (77 aa) |
| | atpF | ATP synthase F0, B subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (179 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (274 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (550 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (309 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (485 aa) |
| | atpC | H+transporting two-sector ATPase delta/epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (94 aa) |
| | Sare_4008 | TIGRFAM: ATP--cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase; KEGG: stp:Strop_3626 ATP--cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (190 aa) |
| | Sare_3999 | KEGG: stp:Strop_3617 hypothetical protein. (95 aa) |
| | Sare_3975 | PFAM: von Willebrand factor type A; KEGG: stp:Strop_3594 von Willebrand factor, type A. (583 aa) |
| | tmk-2 | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (237 aa) |
| | Sare_3959 | RNA polymerase, sigma 70 subunit, RpoD family; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (329 aa) |
| | Sare_3950 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (362 aa) |
| | Sare_3935 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: stp:Strop_3561 bifunctional deaminase-reductase domain protein. (181 aa) |
| | cobD | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (332 aa) |
| | cobQ | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (575 aa) |
| | Sare_3927 | KEGG: stp:Strop_3552 hypothetical protein. (340 aa) |
| | cobT | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (363 aa) |
| | Sare_3920 | TIGRFAM: uroporphyrin-III C-methyltransferase; siroheme synthase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: stp:Strop_3545 uroporphyrin-III C-methyltransferase. (419 aa) |
| | kynU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (430 aa) |
| | kmo | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily. (446 aa) |
| | Sare_3871 | TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein; KEGG: stp:Strop_3492 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. (444 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | nadD | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (198 aa) |
| | Sare_3838 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (407 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (627 aa) |
| | Sare_3795 | PFAM: amine oxidase; KEGG: stp:Strop_3418 amine oxidase. (413 aa) |
| | Sare_3780 | TIGRFAM: phage/plasmid primase, P4 family; PFAM: primase P4; KEGG: sco:SCP1.196 putative dna primase/helicase. (874 aa) |
| | Sare_3729 | TIGRFAM: phage/plasmid primase, P4 family; PFAM: primase P4; KEGG: sco:SCP1.196 putative dna primase/helicase. (874 aa) |
| | Sare_3676 | KEGG: nfa:nfa47330 hypothetical protein. (180 aa) |
| | Sare_3640 | KEGG: stp:Strop_3397 seryl-tRNA synthetase; TIGRFAM: seryl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Seryl-tRNA synthetase, class IIa-like. (427 aa) |
| | Sare_3598 | KEGG: stp:Strop_3358 hypothetical protein. (198 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (586 aa) |
| | Sare_3581 | PFAM: glutamine amidotransferase class-I; KEGG: stp:Strop_3336 glutamine amidotransferase class-I. (255 aa) |
| | cobS | Cobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (257 aa) |
| | Sare_3545 | Cobalbumin biosynthesis protein; PFAM: Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; cobalbumin biosynthesis protein; KEGG: stp:Strop_3313 cobalbumin biosynthesis protein. (665 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (399 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (353 aa) |
| | Sare_3518 | KEGG: stp:Strop_3286 DNA polymerase III, epsilon subunit; TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Excinuclease ABC C subunit domain protein; Exonuclease RNase T and DNA polymerase III; SMART: Exonuclease. (585 aa) |
| | Sare_3483 | KEGG: stp:Strop_3256 phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase class II; Belongs to the class-II DAHP synthase family. (468 aa) |
| | Sare_3471 | KEGG: stp:Strop_3244 hypothetical protein. (252 aa) |
| | dnaE2 | DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1124 aa) |
| | dinB | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (419 aa) |
| | Sare_3449 | PFAM: CobB/CobQ domain protein glutamine amidotransferase; KEGG: stp:Strop_3223 CobB/CobQ domain protein glutamine amidotransferase. (240 aa) |
| | hisA | KEGG: stp:Strop_3190 bifunctional HisA/TrpF protein; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis protein. (241 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (517 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: stp:Strop_3172 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (267 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (410 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (899 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (392 aa) |
| | ctaB | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (317 aa) |
| | Sare_3312 | PFAM: cytochrome oxidase assembly; KEGG: stp:Strop_3085 cytochrome oxidase assembly. (325 aa) |
| | Sare_3277 | PFAM: FAD dependent oxidoreductase; KEGG: stp:Strop_3051 FAD dependent oxidoreductase. (367 aa) |
| | Sare_3265 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; KEGG: stp:Strop_3039 sigma-70 region 2 domain protein; Belongs to the sigma-70 factor family. ECF subfamily. (187 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (343 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (414 aa) |
| | Sare_3204 | PFAM: DNA-directed DNA polymerase; KEGG: stp:Strop_2980 DNA-directed DNA polymerase. (566 aa) |
| | Sare_3172 | KEGG: stp:Strop_2948 hypothetical protein. (194 aa) |
| | Sare_3159 | Transcriptional regulator, SARP family; PFAM: transcriptional regulator domain protein; transcriptional activator domain; KEGG: sco:SCO6280 regulatory protein. (968 aa) |
| | Sare_3126 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: stp:Strop_3776 sigma-70, region 4 type 2; Belongs to the sigma-70 factor family. (295 aa) |
