STRINGSTRING
Sare_3040 Sare_3040 rpsN rpsN rpmG1 rpmG1 rpmB-2 rpmB-2 rpmE2 rpmE2 Sare_2694 Sare_2694 rpmF-2 rpmF-2 Sare_2356 Sare_2356 Sare_2302 Sare_2302 Sare_1924 Sare_1924 Sare_1916 Sare_1916 rplT rplT rpmI rpmI priA priA Sare_1815 Sare_1815 Sare_1769 Sare_1769 Sare_1753 Sare_1753 Sare_1675 Sare_1675 Sare_1674 Sare_1674 Sare_1582 Sare_1582 Sare_1401 Sare_1401 rpsO rpsO Sare_1288 Sare_1288 rpsB rpsB Sare_1212 Sare_1212 rplS rplS rimM rimM rpsP rpsP smc smc rpmF rpmF rpmB rpmB clpS clpS Sare_0934 Sare_0934 rplY rplY Sare_0455 Sare_0455 Sare_0279 Sare_0279 recR recR Sare_0253 Sare_0253 Sare_0155 Sare_0155 gyrA gyrA gyrB gyrB rplP rplP rpsC rpsC rplV rplV rpsS rpsS rplB rplB rplW rplW rplD rplD rplC rplC rpsJ rpsJ rpsG rpsG rpsL rpsL rplL rplL rplJ rplJ rplA rplA rplK rplK rpmG2 rpmG2 Sare_4641 Sare_4641 rpsD-2 rpsD-2 Sare_4826 Sare_4826 Sare_4831 Sare_4831 Sare_4842 Sare_4842 Sare_4997 Sare_4997 Sare_5028 Sare_5028 Sare_5064 Sare_5064 rplI rplI rpsR rpsR rpsF rpsF Sare_5104 Sare_5104 Sare_5105 Sare_5105 rpmH rpmH Sare_3982 Sare_3982 rpmE rpmE Sare_4098 Sare_4098 Sare_4120 Sare_4120 rpsI rpsI rplM rplM rplQ rplQ rpsD rpsD rpsK rpsK rpsM rpsM rpmJ rpmJ rplO rplO rpmD rpmD rpsE rpsE rplR rplR rplF rplF rpsH rpsH rpsZ rpsZ rplE rplE rplX rplX rplN rplN rpsQ rpsQ rpmC rpmC Sare_3931 Sare_3931 rplU rplU rpmA rpmA rpsT rpsT recO recO dnaG dnaG Sare_3801 Sare_3801 Sare_3369 Sare_3369 Sare_3336 Sare_3336
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Sare_3040KEGG: stp:Strop_2864 hypothetical protein. (117 aa)
rpsNRibosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa)
rpmG1PFAM: ribosomal protein L33; KEGG: stp:Strop_2854 ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (55 aa)
rpmB-2PFAM: ribosomal protein L28; KEGG: stp:Strop_2855 ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (78 aa)
rpmE2PFAM: ribosomal protein L31; KEGG: stp:Strop_2857 ribosomal protein L31. (87 aa)
Sare_2694KEGG: stp:Strop_2510 hypothetical protein. (249 aa)
rpmF-2TIGRFAM: ribosomal protein L32; PFAM: ribosomal L32p protein; KEGG: nfa:nfa41850 putative ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (59 aa)
Sare_2356KEGG: stp:Strop_2239 hypothetical protein. (190 aa)
Sare_2302PFAM: Cupin 4 family protein; SMART: transcription factor jumonji jmjC domain protein; KEGG: stp:Strop_2151 cupin 4 family protein. (432 aa)
Sare_1924KEGG: pna:Pnap_0963 hypothetical protein. (616 aa)
Sare_1916PFAM: Cobyrinic acid ac-diamide synthase; KEGG: stp:Strop_1925 cobyrinic acid a,c-diamide synthase. (307 aa)
rplTRibosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (130 aa)
rpmIPFAM: ribosomal protein L35; KEGG: stp:Strop_1883 ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (64 aa)
priAConserved hypothetical protein; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (625 aa)
Sare_1815PFAM: AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; SMART: AAA ATPase; KEGG: stp:Strop_1824 AAA ATPase, central domain protein. (502 aa)
Sare_1769PFAM: ADP-ribosylation/Crystallin J1; KEGG: stp:Strop_1782 ADP-ribosylation/crystallin J1. (306 aa)
Sare_1753KEGG: stp:Strop_1767 hypothetical protein. (327 aa)
Sare_1675PFAM: DNA gyrase/topoisomerase IV subunit A; DNA gyrase repeat beta-propeller; KEGG: stp:Strop_1681 DNA topoisomerase (ATP-hydrolyzing). (827 aa)
Sare_1674PFAM: DNA gyrase subunit B domain protein; ATP-binding region ATPase domain protein; TOPRIM domain protein; DNA topoisomerase type IIA subunit B region 2 domain protein; SMART: DNA topoisomerase II; KEGG: stp:Strop_1680 DNA topoisomerase, type IIA, subunit B, region 2 domain protein. (730 aa)
Sare_1582KEGG: stp:Strop_4126 hypothetical protein. (151 aa)
Sare_1401PFAM: protein of unknown function DUF349; KEGG: stp:Strop_1443 protein of unknown function DUF349. (402 aa)
rpsORibosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (89 aa)
Sare_1288KEGG: bja:blr2149 hypothetical protein. (531 aa)
rpsBPFAM: ribosomal protein S2; KEGG: stp:Strop_1322 ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (279 aa)
Sare_1212KEGG: sen:SACE_7030 possible phiRv2 prophage protein. (410 aa)
rplSRibosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (118 aa)
rimM16S rRNA processing protein RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (180 aa)
rpsPPFAM: ribosomal protein S16; KEGG: stp:Strop_1305 ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (158 aa)
smcChromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1198 aa)
rpmFTIGRFAM: ribosomal protein L32; PFAM: ribosomal L32p protein; KEGG: stp:Strop_1285 ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (57 aa)
rpmBPFAM: ribosomal protein L28; KEGG: stp:Strop_1277 ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (63 aa)
clpSATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (96 aa)
Sare_0934Hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection; Belongs to the YbaB/EbfC family. (163 aa)
rplYRibosomal 5S rRNA E-loop binding protein Ctc/L25/TL5; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (234 aa)
Sare_0455KEGG: stp:Strop_0384 hypothetical protein. (311 aa)
Sare_0279KEGG: stp:Strop_0239 hypothetical protein. (162 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (197 aa)
Sare_0253Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (117 aa)
Sare_0155PFAM: protein of unknown function DUF74; KEGG: stp:Strop_0148 protein of unknown function DUF74; Belongs to the UPF0145 family. (154 aa)
gyrADNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (839 aa)
gyrBDNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (648 aa)
rplPRibosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (141 aa)
rpsCRibosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (288 aa)
rplVRibosomal protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (152 aa)
rpsSRibosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa)
rplBRibosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (279 aa)
rplWRibosomal protein L25/L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (100 aa)
rplDRibosomal protein L4/L1e; Forms part of the polypeptide exit tunnel. (216 aa)
rplCRibosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (219 aa)
rpsJRibosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
rpsGRibosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rpsLRibosomal protein S12; With S4 and S5 plays an important role in translational accuracy. (124 aa)
rplLRibosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (129 aa)
rplJRibosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (181 aa)
rplARibosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (238 aa)
rplKRibosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (143 aa)
rpmG2PFAM: ribosomal protein L33; KEGG: stp:Strop_3942 ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (55 aa)
Sare_4641PFAM: ADP-ribosylation/Crystallin J1; KEGG: stp:Strop_4210 ADP-ribosylation/crystallin J1. (335 aa)
rpsD-2RNA-binding S4 domain protein; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (202 aa)
Sare_4826KEGG: sen:SACE_5480 hypothetical protein. (174 aa)
Sare_4831Hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection; Belongs to the YbaB/EbfC family. (138 aa)
Sare_4842Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (99 aa)
Sare_4997KEGG: stp:Strop_4483 hypothetical protein. (289 aa)
Sare_5028KEGG: stp:Strop_4518 hypothetical protein. (245 aa)
Sare_5064Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (844 aa)
rplIRibosomal protein L9; Binds to the 23S rRNA. (148 aa)
rpsRRibosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (79 aa)
rpsFRibosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (96 aa)
Sare_5104TIGRFAM: parB-like partition protein; PFAM: ParB domain protein nuclease; KEGG: stp:Strop_4586 ParB-like partition protein; Belongs to the ParB family. (335 aa)
Sare_5105PFAM: Cobyrinic acid ac-diamide synthase; KEGG: stp:Strop_4587 cobyrinic acid a,c-diamide synthase. (437 aa)
rpmHPFAM: ribosomal protein L34; KEGG: stp:Strop_4593 ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (45 aa)
Sare_3982KEGG: stp:Strop_3601 hypothetical protein. (127 aa)
rpmERibosomal protein L31; Binds the 23S rRNA. (74 aa)
Sare_4098PFAM: protein of unknown function DUF159; KEGG: stp:Strop_3717 protein of unknown function DUF159; Belongs to the SOS response-associated peptidase family. (239 aa)
Sare_4120PFAM: UvrD/REP helicase; HRDC domain protein; KEGG: stp:Strop_3739 UvrD/REP helicase. (719 aa)
rpsIPFAM: ribosomal protein S9; KEGG: stp:Strop_3863 ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (154 aa)
rplMRibosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (147 aa)
rplQPFAM: ribosomal protein L17; KEGG: stp:Strop_3894 ribosomal protein L17. (190 aa)
rpsDRNA-binding S4 domain protein; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (208 aa)
rpsKRibosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (135 aa)
rpsMRibosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (126 aa)
rpmJPFAM: ribosomal protein L36; KEGG: stp:Strop_3899 ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (37 aa)
rplORibosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (147 aa)
rpmDPFAM: ribosomal protein L30; KEGG: stp:Strop_3905 ribosomal protein L30. (60 aa)
rpsERibosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (204 aa)
rplRRibosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (129 aa)
rplFRibosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (180 aa)
rpsHRibosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (135 aa)
rpsZRibosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rplERibosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (189 aa)
rplXRibosomal protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (106 aa)
rplNRibosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rpsQRibosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (91 aa)
rpmCPFAM: ribosomal protein L29; KEGG: stp:Strop_3915 ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (78 aa)
Sare_3931KEGG: stp:Strop_3557 hypothetical protein. (129 aa)
rplURibosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (104 aa)
rpmAPFAM: ribosomal protein L27; KEGG: stp:Strop_3480 ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (84 aa)
rpsTRibosomal protein S20; Binds directly to 16S ribosomal RNA. (88 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (300 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (627 aa)
Sare_3801KEGG: stp:Strop_3424 hypothetical protein. (178 aa)
Sare_3369PFAM: RNA binding S1 domain protein; KEGG: stp:Strop_3140 RNA binding S1 domain protein. (493 aa)
Sare_3336KEGG: stp:Strop_3105 ATP-dependent DNA helicase RecQ; TIGRFAM: ATP-dependent DNA helicase, RecQ family; ATP-dependent DNA helicase RecQ; PFAM: helicase domain protein; HRDC domain protein; DEAD/DEAH box helicase domain protein; Helicase superfamily 1 and 2 ATP-binding; SMART: DEAD-like helicases. (616 aa)
Your Current Organism:
Salinispora arenicola
NCBI taxonomy Id: 391037
Other names: S. arenicola CNS-205, Salinispora arenicola CNS-205, Salinispora arenicola str. CNS-205, Salinispora arenicola strain CNS-205
Server load: low (16%) [HD]