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| | Sare_0135 | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (340 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (584 aa) |
| | Sare_0265 | KEGG: stp:Strop_0226 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (421 aa) |
| | Sare_0266 | KEGG: stp:Strop_0227 aspartate-semialdehyde dehydrogenase; TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase NAD - binding; Semialdehyde dehydrogenase dimerisation region; Belongs to the aspartate-semialdehyde dehydrogenase family. (353 aa) |
| | Sare_0305 | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: stp:Strop_0263 threonine synthase. (428 aa) |
| | Sare_0354 | Diaminobutyrate--2-oxoglutarate aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (430 aa) |
| | Sare_0355 | PFAM: aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; KEGG: sma:SAV3641 putative ornithine carbamoyltransferase. (310 aa) |
| | gpmA | Phosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (255 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (413 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (369 aa) |
| | Sare_0486 | PFAM: Orn/DAP/Arg decarboxylase 2; KEGG: atc:AGR_C_3079 hypothetical protein. (417 aa) |
| | Sare_0510 | Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (375 aa) |
| | Sare_0511 | PFAM: Citrate synthase; KEGG: stp:Strop_0423 citrate (Si)-synthase; Belongs to the citrate synthase family. (368 aa) |
| | Sare_0518 | KEGG: stp:Strop_0430 L-serine dehydratase 1; TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (465 aa) |
| | Sare_0567 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: mka:MK0297 predicted dehydrogenase related to phosphoglycerate dehydrogenase. (345 aa) |
| | Sare_0588 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (217 aa) |
| | Sare_0630 | Quorum-sensing autoinducer 2 (AI-2), LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (165 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa) |
| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa) |
| | Sare_0836 | PFAM: GCN5-related N-acetyltransferase; KEGG: stp:Strop_0893 GCN5-related N-acetyltransferase; Belongs to the acetyltransferase family. (170 aa) |
| | Sare_0855 | TIGRFAM: cystathionine beta-synthase; PFAM: CBS domain containing protein; Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: stp:Strop_0912 cystathionine beta-synthase. (456 aa) |
| | Sare_0860 | TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase class-II; asparagine synthase; KEGG: stp:Strop_0917 asparagine synthase (glutamine-hydrolyzing). (594 aa) |
| | Sare_0863 | Cystathionine gamma-synthase; PFAM: aminotransferase class V; Cys/Met metabolism pyridoxal-phosphate-dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: stp:Strop_0920 cystathionine gamma-synthase. (380 aa) |
| | Sare_0865 | TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; amino acid-binding ACT domain protein; KEGG: stp:Strop_0922 threonine dehydratase. (406 aa) |
| | Sare_1048 | PFAM: alanine dehydrogenase/PNT domain protein; KEGG: sma:SAV1788 saccharopine dehydrogenase. (359 aa) |
| | Sare_1100 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: stp:Strop_1207 thiamine pyrophosphate enzyme domain protein TPP-binding; Belongs to the TPP enzyme family. (540 aa) |
| | ilvD | KEGG: stp:Strop_1231 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (615 aa) |
| | Sare_1123 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: stp:Strop_1233 acetolactate synthase, large subunit, biosynthetic type. (629 aa) |
| | Sare_1124 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: stp:Strop_1234 acetolactate synthase, small subunit. (171 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa) |
| | Sare_1126 | TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: stp:Strop_1236 D-3-phosphoglycerate dehydrogenase. (531 aa) |
| | Sare_1129 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: stp:Strop_1239 3-isopropylmalate dehydrogenase. (343 aa) |
| | Sare_1130 | TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV; KEGG: stp:Strop_1240 branched-chain amino acid aminotransferase. (365 aa) |
| | Sare_1133 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: stp:Strop_1243 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (527 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (481 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (195 aa) |
| | Sare_1158 | PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: stp:Strop_1267 Cys/Met metabolism pyridoxal-phosphate-dependent enzyme. (373 aa) |
| | Sare_1272 | PFAM: Transketolase domain protein; KEGG: sen:SACE_5763 putative transketolase. (245 aa) |
| | Sare_1273 | PFAM: Transketolase central region; KEGG: sen:SACE_5762 transketolase B subunit. (303 aa) |
| | Sare_1274 | PFAM: UBA/THIF-type NAD/FAD binding protein; Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: fal:FRAAL0918 aminoquinate/shkimate dehydrogenase. (270 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (256 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (308 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (278 aa) |
| | Sare_1618 | TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase class-II; asparagine synthase; KEGG: stp:Strop_1632 asparagine synthase (glutamine-hydrolyzing). (920 aa) |
| | Sare_1822 | TIGRFAM: shikimate-5-dehydrogenase; PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: stp:Strop_1831 shikimate-5-dehydrogenase; Belongs to the shikimate dehydrogenase family. (275 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (402 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (167 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (357 aa) |
| | aroQ-2 | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (143 aa) |
| | metK | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (399 aa) |
| | Sare_1865 | PFAM: ribulose-phosphate 3-epimerase; KEGG: stp:Strop_1872 ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (226 aa) |
| | Sare_1872 | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: stp:Strop_1879 phosphoribosyl-ATP pyrophosphohydrolase; Belongs to the PRA-PH family. (100 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (294 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (333 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (389 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (295 aa) |
| | argD | TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class-III; KEGG: stp:Strop_1891 acetylornithine and succinylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (429 aa) |
| | Sare_1885 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (323 aa) |
| | argG | PFAM: argininosuccinate synthase; KEGG: stp:Strop_1894 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (403 aa) |
| | argH | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: stp:Strop_1895 argininosuccinate lyase. (487 aa) |
| | Sare_2059 | PFAM: purine or other phosphorylase family 1; KEGG: stp:Strop_4371 purine or other phosphorylase, family 1. (384 aa) |
| | Sare_2067 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: sma:SAV1372 acetolactate synthase; Belongs to the TPP enzyme family. (568 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (478 aa) |
| | Sare_2284 | KEGG: stp:Strop_2136 citrate synthase I; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family. (427 aa) |
| | Sare_2325 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1171 aa) |
| | Sare_2728 | KEGG: stp:Strop_2541 asparagine synthase (glutamine-hydrolyzing); TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase class-II; asparagine synthase. (593 aa) |
| | Sare_2784 | PFAM: aminotransferase class I and II; KEGG: stp:Strop_2586 aminotransferase, class I and II. (421 aa) |
| | Sare_2955 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: bbr:BB0923 putative acetolactate synthase large subunit; Belongs to the TPP enzyme family. (565 aa) |
| | Sare_2956 | TIGRFAM: cystathionine beta-synthase; PFAM: CBS domain containing protein; Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: tfu:Tfu_0438 cystathionine beta-synthase. (465 aa) |
| | Sare_3058 | PFAM: Orn/DAP/Arg decarboxylase 2; KEGG: stp:Strop_0681 Orn/DAP/Arg decarboxylase 2; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (418 aa) |
| | Sare_3061 | Pyridoxal-5'-phosphate-dependent protein beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (447 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (414 aa) |
| | Sare_3283 | KEGG: stp:Strop_3057 asparagine synthase (glutamine-hydrolyzing); TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase class-II; asparagine synthase. (653 aa) |
| | Sare_3289 | TIGRFAM: aconitate hydratase 1; PFAM: aconitate hydratase domain protein; KEGG: stp:Strop_3062 aconitate hydratase 1. (948 aa) |
| | Sare_3316 | TIGRFAM: transketolase; PFAM: Transketolase domain protein; Transketolase central region; KEGG: stp:Strop_3089 transketolase; Belongs to the transketolase family. (712 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (392 aa) |
| | Sare_3318 | PFAM: phosphoglucose isomerase (PGI); KEGG: stp:Strop_3091 phosphoglucose isomerase (PGI); Belongs to the GPI family. (559 aa) |
| | tpiA | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (263 aa) |
| | pgk | PFAM: phosphoglycerate kinase; KEGG: stp:Strop_3097 phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (399 aa) |
| | Sare_3325 | KEGG: stp:Strop_3098 glyceraldehyde-3-phosphate dehydrogenase, type I; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa) |
| | Sare_3385 | KEGG: stp:Strop_3160 pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (482 aa) |
| | Sare_3391 | TIGRFAM: glutamate synthase, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: stp:Strop_3166 glutamate synthase, NADH/NADPH, small subunit. (501 aa) |
| | Sare_3392 | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: stp:Strop_3167 ferredoxin-dependent glutamate synthase. (1573 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (410 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: stp:Strop_3172 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (267 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (517 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (147 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (255 aa) |
| | hisA | KEGG: stp:Strop_3190 bifunctional HisA/TrpF protein; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis protein. (241 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (210 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: stp:Strop_3194 imidazoleglycerol-phosphate dehydratase. (203 aa) |
| | hisC | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: stp:Strop_3195 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (358 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (440 aa) |
| | Sare_3482 | Threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: stp:Strop_3255 threonine aldolase. (343 aa) |
| | Sare_3483 | KEGG: stp:Strop_3256 phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase class II; Belongs to the class-II DAHP synthase family. (468 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (272 aa) |
| | pfp | Diphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (342 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (353 aa) |
| | Sare_3568 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: stp:Strop_3332 glutamine synthetase, type I. (474 aa) |
| | Sare_3584 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: stp:Strop_3339 glutamine synthetase, type I. (451 aa) |
| | Sare_3889 | Ribose 5-phosphate isomerase; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase; PFAM: Ribose/galactose isomerase; KEGG: stp:Strop_3514 ribose 5-phosphate isomerase. (155 aa) |
| | Sare_3922 | PFAM: aminotransferase class I and II; KEGG: stp:Strop_3547 aminotransferase, class I and II. (366 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (341 aa) |
| | Sare_3950 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (362 aa) |
| | Sare_3987 | PFAM: Arginase/agmatinase/formiminoglutamase; KEGG: stp:Strop_3606 arginase/agmatinase/formiminoglutamase; Belongs to the arginase family. (395 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (314 aa) |
| | Sare_4032 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (349 aa) |
| | Sare_4033 | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; KEGG: stp:Strop_3651 homoserine dehydrogenase. (437 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (470 aa) |
| | aroA-2 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (433 aa) |
| | Sare_4101 | TIGRFAM: histidinol-phosphate phosphatase, putative; PFAM: inositol monophosphatase; KEGG: stp:Strop_3720 histidinol-phosphate phosphatase, putative. (272 aa) |
| | Sare_4106 | KEGG: stp:Strop_3725 ribose-phosphate pyrophosphokinase; TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase. (312 aa) |
| | Sare_4134 | TIGRFAM: succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: stp:Strop_3752 succinyl-diaminopimelate desuccinylase. (357 aa) |
| | dapD | Conserved hypothetical protein; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (319 aa) |
| | Sare_4139 | PFAM: Prephenate dehydrogenase; 6-phosphogluconate dehydrogenase NAD-binding; KEGG: stp:Strop_3757 prephenate dehydrogenase. (348 aa) |
| | Sare_4142 | PFAM: GCN5-related N-acetyltransferase; KEGG: stp:Strop_3760 GCN5-related N-acetyltransferase. (320 aa) |
| | Sare_4173 | KEGG: stp:Strop_3793 isocitrate dehydrogenase, NADP-dependent; TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa) |
| | Sare_4208 | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; KEGG: stp:Strop_3818 chorismate mutase. (112 aa) |
| | Sare_4251 | Aminotransferase class I and II; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class I and II; KEGG: stp:Strop_3861 aminotransferase, class I and II. (397 aa) |
| | Sare_4509 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: stp:Strop_4089 pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (363 aa) |
| | pat | Histidinol-phosphate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (367 aa) |
| | Sare_4985 | PFAM: Transketolase domain protein; KEGG: stp:Strop_4472 transketolase domain protein. (242 aa) |
| | Sare_4986 | PFAM: Transketolase central region; KEGG: stp:Strop_4473 transketolase, central region. (296 aa) |
| | pheA | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: stp:Strop_4522 prephenate dehydratase. (318 aa) |
