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cysN cysN ABI63056.1 ABI63056.1 ABI62984.1 ABI62984.1 ABI62978.1 ABI62978.1 sucD-2 sucD-2 ABI62966.1 ABI62966.1 ABI62965.1 ABI62965.1 ppk ppk accD accD ABI62856.1 ABI62856.1 ABI62855.1 ABI62855.1 ABI62832.1 ABI62832.1 ABI62831.1 ABI62831.1 ABI62830.1 ABI62830.1 ABI62790.1 ABI62790.1 cysD cysD ABI62635.1 ABI62635.1 leuC leuC leuD leuD ABI62412.1 ABI62412.1 ABI62253.1 ABI62253.1 clpX clpX ABI62196.1 ABI62196.1 ABI62195.1 ABI62195.1 uvrA uvrA ABI62083.1 ABI62083.1 ABI62082.1 ABI62082.1 eno eno ruvB ruvB ruvA ruvA ABI61974.1 ABI61974.1 ribH ribH rpoZ rpoZ ABI61785.1 ABI61785.1 ABI61732.1 ABI61732.1 ABI61662.1 ABI61662.1 ABI61602.1 ABI61602.1 ABI61594.1 ABI61594.1 cobQ cobQ ABI61541.1 ABI61541.1 accA accA rpoA rpoA rpoC rpoC rpoB rpoB ABI61401.1 ABI61401.1 ABI61217.1 ABI61217.1 dnaX dnaX ssuD ssuD ABI61123.1 ABI61123.1 xseB xseB ABI61055.1 ABI61055.1 ABI60953.1 ABI60953.1 sucD sucD ABI60905.1 ABI60905.1 gpsA gpsA ABI63318.1 ABI63318.1 trmB trmB ABI63285.1 ABI63285.1 ABI63284.1 ABI63284.1 glgC glgC xseA xseA carA carA dnaG dnaG hslU hslU hslV hslV uvrC uvrC uvrB uvrB ABI63101.1 ABI63101.1 ureB ureB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
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textmining
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cysNSulfate adenylyltransferase subunit 1; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (625 aa)
ABI63056.1Hypothetical protein. (736 aa)
ABI62984.1Molybdopterin converting factor, small subunit. (87 aa)
ABI62978.1Succinate dehydrogenase cytochrome b556 subunit. (197 aa)
sucD-2succinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (291 aa)
ABI62966.12-oxoglutarate dehydrogenase E1 component. (963 aa)
ABI62965.1Dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (470 aa)
ppkPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (760 aa)
accDAcetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (305 aa)
ABI62856.1Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (161 aa)
ABI62855.1Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (456 aa)
ABI62832.1NAD-dependent formate dehydrogenase alpha subunit (fdsA). (947 aa)
ABI62831.1NAD-dependent formate dehydrogenase beta subunit (fdsB). (518 aa)
ABI62830.1NAD-dependent formate dehydrogenase gamma subunit (fdsG). (159 aa)
ABI62790.1Ethanolamine ammonia-lyase light chain; Belongs to the EutC family. (266 aa)
cysDSulfate adenylyltransferase subunit 2. (308 aa)
ABI62635.1Vitamin B12-dependent ribonucleotide reductase. (516 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (471 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (208 aa)
ABI62412.1traI protein (DNA helicase I). (571 aa)
ABI62253.1Hypothetical secreted protein. (171 aa)
clpXATP-dependent endopeptidase clp ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (420 aa)
ABI62196.1NADH-quinone oxidoreductase chain E. (227 aa)
ABI62195.1NADH-quinone oxidoreductase chain F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (438 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (987 aa)
ABI62083.1Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (416 aa)
ABI62082.1Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (455 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (425 aa)
ruvBHolliday junction DNA helicase ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (359 aa)
ruvAHolliday junction DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (204 aa)
ABI61974.1DNA polymerase III, delta' subunit. (342 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (168 aa)
rpoZDNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (136 aa)
ABI61785.1Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (650 aa)
ABI61732.1ATP-dependent DNA helicase recG. (685 aa)
ABI61662.1Flavoprotein. (198 aa)
ABI61602.1Glutamate synthase [NADPH] large chain. (1524 aa)
ABI61594.1RNA polymerase sigma-54 factor rpoN; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (537 aa)
cobQAdenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (481 aa)
ABI61541.1Alkanesulfonate monooxygenase. (359 aa)
accAAcetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (327 aa)
rpoADNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (339 aa)
rpoCDNA-directed RNA polymerase beta' chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1387 aa)
rpoBDNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1391 aa)
ABI61401.1Hypothetical protein. (879 aa)
ABI61217.1DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] (387 aa)
dnaXDNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (686 aa)
ssuDAlkanesulfonate monooxygenase; Catalyzes the desulfonation of aliphatic sulfonates. Belongs to the SsuD family. (394 aa)
ABI61123.1Enoyl-[acyl-carrier protein] reductase (NADH). (277 aa)
xseBExodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (88 aa)
ABI61055.1Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (420 aa)
ABI60953.1malyl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. (331 aa)
sucDsuccinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (298 aa)
ABI60905.1DNA polymerase III, delta subunit. (351 aa)
gpsAGlycerol-3-phosphate dehydrogenase (NAD(P)+); Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (323 aa)
ABI63318.1Dibenzothiophene sulfone monooxygenase. (460 aa)
trmBtRNA (m(7)G46) methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (227 aa)
ABI63285.1Formate hydrogenlyase subunit 7. (174 aa)
ABI63284.1Formate hydrogenlyase subunit 5. (517 aa)
glgCGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (444 aa)
xseAExodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (543 aa)
carACarbamoyl-phosphate synthase small chain; Belongs to the CarA family. (478 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. (616 aa)
hslUATP-dependent endopeptidase hsl ATP-binding subunit hslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (438 aa)
hslVATP-dependent endopeptidase hsl proteolytic subunit hslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. (212 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (644 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (746 aa)
ABI63101.1DNA polymerase III, chi subunit. (149 aa)
ureBUrease beta subunit; Belongs to the urease beta subunit family. (101 aa)
Your Current Organism:
Granulibacter bethesdensis
NCBI taxonomy Id: 391165
Other names: G. bethesdensis CGDNIH1, Granulibacter bethesdensis CGDNIH1, Granulibacter bethesdensis str. CGDNIH1, Granulibacter bethesdensis strain CGDNIH1
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