(42 nodes) RNA Polymerase II Transcription Elongation network (Enhydra lutris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111140117	RNA polymerase-associated protein LEO1-like. (298 aa)
	LOC111141477	Transcription elongation factor A protein 2 isoform X1. (317 aa)
	LOC111145930	Uroplakin-3b-like protein 1. (266 aa)
	LOC111145948	DNA-directed RNA polymerase II subunit RPB11-a isoform X1. (128 aa)
	LOC111146668	DNA-directed RNA polymerases I, II, and III subunit RPABC4. (58 aa)
	LOC111145130	DNA excision repair protein ERCC-6. (1482 aa)
	LOC111147490	DNA-directed RNA polymerases I, II, and III subunit RPABC5-like. (86 aa)
	LOC111145838	DNA-directed RNA polymerase II subunit RPB11-a-like. (133 aa)
	LOC111148194	DNA-directed RNA polymerases I, II, and III subunit RPABC5-like. (67 aa)
	LOC111148606	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
	LOC111148436	SID1 transmembrane family member 1 isoform X2. (834 aa)
	LOC111149241	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
	LOC111149491	FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (709 aa)
	LOC111148672	Cyclin-dependent kinase 2-interacting protein. (212 aa)
	LOC111150095	DNA-directed RNA polymerases I, II, and III subunit RPABC5. (67 aa)
	LOC111149297	UV-stimulated scaffold protein A. (712 aa)
	LOC111151037	Parafibromin. (531 aa)
	LOC111149658	DNA-directed RNA polymerase II subunit RPB7. (172 aa)
	LOC111152159	LOW QUALITY PROTEIN: uncharacterized protein C6orf15 homolog. (328 aa)
	LOC111151321	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa)
	LOC111153155	FACT complex subunit SPT16. (1047 aa)
	LOC111154232	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (960 aa)
	LOC111151754	Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II; Belongs to the SPT4 family. (132 aa)
	LOC111154743	elongin-A. (800 aa)
	LOC111155444	Transcription elongation factor A protein 1. (301 aa)
	LOC111154764	Transcription elongation factor A protein 3. (348 aa)
	LOC111156946	DNA excision repair protein ERCC-8 isoform X1. (400 aa)
	LOC111157687	DNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform X1. (130 aa)
	LOC111157404	DNA-directed RNA polymerase II subunit RPB3. (275 aa)
	LOC111158153	Uncharacterized protein C17orf53 homolog. (648 aa)
	LOC111160865	Protein IWS1 homolog. (821 aa)
	LOC111161378	RNA polymerase II-associated factor 1 homolog isoform X2. (536 aa)
	LOC111160866	DNA-directed RNA polymerase II subunit RPB4. (142 aa)
	LOC111161337	RNA polymerase-associated protein RTF1 homolog. (710 aa)
	LOC111161572	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
	LOC111161116	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1970 aa)
	LOC111161893	DNA-directed RNA polymerases I, II, and III subunit RPABC1. (210 aa)
	LOC111159484	RNA polymerase-associated protein CTR9 homolog isoform X1. (1173 aa)
	LOC111161088	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1697 aa)
	LOC111161423	Transcription elongation factor SPT5. (1087 aa)
	LOC111160609	RNA polymerase-associated protein LEO1 isoform X1. (665 aa)
	LOC111162561	Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. (83 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111140117	LOC111141477	A0A2Y9IIW4	A0A2Y9INJ1	RNA polymerase-associated protein LEO1-like.	Transcription elongation factor A protein 2 isoform X1.	0.617
LOC111140117	LOC111145130	A0A2Y9IIW4	A0A2Y9JCL6	RNA polymerase-associated protein LEO1-like.	DNA excision repair protein ERCC-6.	0.712
LOC111140117	LOC111145838	A0A2Y9IIW4	A0A2Y9JGB7	RNA polymerase-associated protein LEO1-like.	DNA-directed RNA polymerase II subunit RPB11-a-like.	0.714
LOC111140117	LOC111145930	A0A2Y9IIW4	A0A2Y9J7M4	RNA polymerase-associated protein LEO1-like.	Uroplakin-3b-like protein 1.	0.714
LOC111140117	LOC111145948	A0A2Y9IIW4	A0A2Y9J8Q0	RNA polymerase-associated protein LEO1-like.	DNA-directed RNA polymerase II subunit RPB11-a isoform X1.	0.714
LOC111140117	LOC111146668	A0A2Y9IIW4	A0A2Y9JAH9	RNA polymerase-associated protein LEO1-like.	DNA-directed RNA polymerases I, II, and III subunit RPABC4.	0.967
LOC111140117	LOC111147490	A0A2Y9IIW4	A0A2Y9JDY0	RNA polymerase-associated protein LEO1-like.	DNA-directed RNA polymerases I, II, and III subunit RPABC5-like.	0.739
LOC111140117	LOC111148194	A0A2Y9IIW4	A0A2Y9JH79	RNA polymerase-associated protein LEO1-like.	DNA-directed RNA polymerases I, II, and III subunit RPABC5-like.	0.739
LOC111140117	LOC111148436	A0A2Y9IIW4	A0A2Y9JJB1	RNA polymerase-associated protein LEO1-like.	SID1 transmembrane family member 1 isoform X2.	0.596
LOC111140117	LOC111148606	A0A2Y9IIW4	A0A2Y9JJ45	RNA polymerase-associated protein LEO1-like.	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.	0.968
LOC111140117	LOC111148672	A0A2Y9IIW4	A0A2Y9JNI2	RNA polymerase-associated protein LEO1-like.	Cyclin-dependent kinase 2-interacting protein.	0.994
LOC111140117	LOC111149241	A0A2Y9IIW4	A0A2Y9JMS8	RNA polymerase-associated protein LEO1-like.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.978
LOC111140117	LOC111149297	A0A2Y9IIW4	A0A2Y9JR25	RNA polymerase-associated protein LEO1-like.	UV-stimulated scaffold protein A.	0.765
LOC111140117	LOC111149491	A0A2Y9IIW4	A0A2Y9JMW3	RNA polymerase-associated protein LEO1-like.	FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]	0.993
LOC111140117	LOC111149658	A0A2Y9IIW4	A0A2Y9JYD0	RNA polymerase-associated protein LEO1-like.	DNA-directed RNA polymerase II subunit RPB7.	0.972
LOC111140117	LOC111150095	A0A2Y9IIW4	A0A2Y9JQ60	RNA polymerase-associated protein LEO1-like.	DNA-directed RNA polymerases I, II, and III subunit RPABC5.	0.739
LOC111140117	LOC111151037	A0A2Y9IIW4	A0A2Y9JTS6	RNA polymerase-associated protein LEO1-like.	Parafibromin.	0.999
LOC111140117	LOC111151321	A0A2Y9IIW4	A0A2Y9JZL8	RNA polymerase-associated protein LEO1-like.	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family.	0.979
LOC111140117	LOC111151754	A0A2Y9IIW4	A0A2Y9K804	RNA polymerase-associated protein LEO1-like.	Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II; Belongs to the SPT4 family.	0.979
LOC111140117	LOC111152159	A0A2Y9IIW4	A0A2Y9JYK2	RNA polymerase-associated protein LEO1-like.	LOW QUALITY PROTEIN: uncharacterized protein C6orf15 homolog.	0.945