STRINGSTRING
LOC111139223 LOC111139223 LOC111141232 LOC111141232 LOC111140259 LOC111140259 LOC111141466 LOC111141466 LOC111142174 LOC111142174 LOC111142104 LOC111142104 LOC111142576 LOC111142576 LOC111142798 LOC111142798 LOC111143222 LOC111143222 LOC111143247 LOC111143247 LOC111142602 LOC111142602 LOC111142182 LOC111142182 LOC111143518 LOC111143518 LOC111144562 LOC111144562 LOC111144619 LOC111144619 LOC111145481 LOC111145481 LOC111145541 LOC111145541 LOC111146214 LOC111146214 LOC111145153 LOC111145153 LOC111146910 LOC111146910 LOC111148133 LOC111148133 LOC111148474 LOC111148474 LOC111148980 LOC111148980 LOC111149679 LOC111149679 LOC111150060 LOC111150060 LOC111149999 LOC111149999 LOC111150422 LOC111150422 LOC111150485 LOC111150485 LOC111150494 LOC111150494 LOC111150863 LOC111150863 LOC111150009 LOC111150009 LOC111151363 LOC111151363 LOC111151490 LOC111151490 LOC111151322 LOC111151322 LOC111151828 LOC111151828 LOC111153007 LOC111153007 LOC111152603 LOC111152603 LOC111152728 LOC111152728 LOC111153791 LOC111153791 LOC111154148 LOC111154148 LOC111154118 LOC111154118 LOC111155230 LOC111155230 LOC111154441 LOC111154441 LOC111156081 LOC111156081 LOC111155943 LOC111155943 LOC111156326 LOC111156326 LOC111156374 LOC111156374 LOC111156402 LOC111156402 LOC111154511 LOC111154511 LOC111155163 LOC111155163 LOC111157035 LOC111157035 LOC111157193 LOC111157193 LOC111159337 LOC111159337 LOC111160461 LOC111160461 LOC111158468 LOC111158468 LOC111160374 LOC111160374
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC111139223Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (453 aa)
LOC111141232Pterin-4-alpha-carbinolamine dehydratase 2. (130 aa)
LOC111140259Histidine decarboxylase isoform X1. (663 aa)
LOC111141466Spermine oxidase isoform X1. (585 aa)
LOC111142174Tryptophan 5-hydroxylase 2 isoform X2. (497 aa)
LOC111142104Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (486 aa)
LOC111142576Catechol O-methyltransferase isoform X1. (318 aa)
LOC111142798Amine oxidase. (525 aa)
LOC111143222Histamine N-methyltransferase isoform X2. (304 aa)
LOC111143247Kynurenine--oxoglutarate transaminase 3 isoform X1. (454 aa)
LOC111142602Macrophage migration inhibitory factor. (115 aa)
LOC111142182Phenylalanine-4-hydroxylase. (450 aa)
LOC111143518Alcohol dehydrogenase [NADP(+)]. (325 aa)
LOC111144562Indoleamine 2,3-dioxygenase 2. (406 aa)
LOC111144619Indoleamine 2,3-dioxygenase 1. (354 aa)
LOC1111454812-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (336 aa)
LOC111145541Kynurenine--oxoglutarate transaminase 1 isoform X1. (554 aa)
LOC111146214Dopamine beta-hydroxylase. (610 aa)
LOC111145153Pterin-4-alpha-carbinolamine dehydratase. (104 aa)
LOC111146910S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (292 aa)
LOC111148133Sepiapterin reductase. (267 aa)
LOC111148474Maleylacetoacetate isomerase isoform X1; Belongs to the GST superfamily. (217 aa)
LOC111148980Dihydropteridine reductase isoform X1. (242 aa)
LOC111149679Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (468 aa)
LOC111150060Tryptophan 5-hydroxylase 1. (444 aa)
LOC111149999Tyrosine 3-monooxygenase isoform X1. (525 aa)
LOC111150422Amine oxidase. (527 aa)
LOC111150485Amine oxidase. (399 aa)
LOC111150494Homogentisate 1,2-dioxygenase. (450 aa)
LOC111150863Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (531 aa)
LOC111150009Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (487 aa)
LOC111151363Amine oxidase. (763 aa)
LOC111151490Amine oxidase. (507 aa)
LOC111151322Amine oxidase. (756 aa)
LOC111151828Phenylethanolamine N-methyltransferase. (287 aa)
LOC111153007Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (454 aa)
LOC111152603Fumarylacetoacetase. (419 aa)
LOC111152728Alcohol dehydrogenase 4-like. (316 aa)
LOC111153791S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (374 aa)
LOC111154148Thyroid peroxidase. (1524 aa)
LOC1111541181,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Belongs to the acireductone dioxygenase (ARD) family. (179 aa)
LOC111155230Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (425 aa)
LOC111154441Tyrosinase. (531 aa)
LOC111156081Acylpyruvase FAHD1, mitochondrial. (221 aa)
LOC1111559433-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (286 aa)
LOC111156326Aldehyde dehydrogenase, mitochondrial isoform X1; Belongs to the aldehyde dehydrogenase family. (521 aa)
LOC1111563744-hydroxyphenylpyruvate dioxygenase. (393 aa)
LOC111156402Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform X2. (429 aa)
LOC111154511Amine oxidase. (756 aa)
LOC111155163Alcohol dehydrogenase E chain. (335 aa)
LOC111157035aromatic-L-amino-acid decarboxylase isoform X1. (480 aa)
LOC111157193Acetylserotonin O-methyltransferase isoform X1. (345 aa)
LOC111159337Transmembrane O-methyltransferase. (277 aa)
LOC111160461Serotonin N-acetyltransferase. (207 aa)
LOC111158468Cytochrome P450 1B1-like; Belongs to the cytochrome P450 family. (544 aa)
LOC111160374Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (307 aa)
Your Current Organism:
Enhydra lutris
NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni
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