(12 nodes) Atrioventricular valve morphogenesis network (Enhydra lutris)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:
	LOC111142120	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
	LOC111143137	Protein CYR61. (382 aa)
	LOC111144836	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
	LOC111141287	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1045 aa)
	LOC111138977	ephrin-A1 isoform X1; Belongs to the ephrin family. (205 aa)
	LOC111140918	Slit homolog 3 protein isoform X1. (1538 aa)
	LOC111145671	Neurogenic locus notch homolog protein 1. (2562 aa)
	LOC111153274	Mothers against decapentaplegic homolog. (497 aa)
	LOC111153009	Zinc finger protein ZFPM1. (907 aa)
	LOC111156507	T-box transcription factor TBX5. (518 aa)
	LOC111141639	LOW QUALITY PROTEIN: bone morphogenetic protein 2. (395 aa)
	LOC111142438	Mothers against decapentaplegic homolog. (552 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111141287	LOC111141639	A0A2Y9IQ32	A0A2Y9IRW7	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	LOW QUALITY PROTEIN: bone morphogenetic protein 2.	0.989
LOC111141287	LOC111142438	A0A2Y9IQ32	A0A2Y9ISJ5	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.800
LOC111141287	LOC111144836	A0A2Y9IQ32	A0A2Y9J3I8	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.977
LOC111141287	LOC111153274	A0A2Y9IQ32	A0A2Y9K338	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.729
LOC111141639	LOC111141287	A0A2Y9IRW7	A0A2Y9IQ32	LOW QUALITY PROTEIN: bone morphogenetic protein 2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.989
LOC111141639	LOC111142438	A0A2Y9IRW7	A0A2Y9ISJ5	LOW QUALITY PROTEIN: bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.804
LOC111141639	LOC111144836	A0A2Y9IRW7	A0A2Y9J3I8	LOW QUALITY PROTEIN: bone morphogenetic protein 2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.999
LOC111141639	LOC111153274	A0A2Y9IRW7	A0A2Y9K338	LOW QUALITY PROTEIN: bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.710
LOC111142120	LOC111145671	A0A2Y9ITY4	A0A2Y9JFB7	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	Neurogenic locus notch homolog protein 1.	0.433
LOC111142438	LOC111141287	A0A2Y9ISJ5	A0A2Y9IQ32	Mothers against decapentaplegic homolog.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.800
LOC111142438	LOC111141639	A0A2Y9ISJ5	A0A2Y9IRW7	Mothers against decapentaplegic homolog.	LOW QUALITY PROTEIN: bone morphogenetic protein 2.	0.804
LOC111142438	LOC111144836	A0A2Y9ISJ5	A0A2Y9J3I8	Mothers against decapentaplegic homolog.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.812
LOC111142438	LOC111145671	A0A2Y9ISJ5	A0A2Y9JFB7	Mothers against decapentaplegic homolog.	Neurogenic locus notch homolog protein 1.	0.432
LOC111142438	LOC111153274	A0A2Y9ISJ5	A0A2Y9K338	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.656
LOC111144836	LOC111141287	A0A2Y9J3I8	A0A2Y9IQ32	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.977
LOC111144836	LOC111141639	A0A2Y9J3I8	A0A2Y9IRW7	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	LOW QUALITY PROTEIN: bone morphogenetic protein 2.	0.999
LOC111144836	LOC111142438	A0A2Y9J3I8	A0A2Y9ISJ5	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.812
LOC111144836	LOC111153274	A0A2Y9J3I8	A0A2Y9K338	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.799
LOC111145671	LOC111142120	A0A2Y9JFB7	A0A2Y9ITY4	Neurogenic locus notch homolog protein 1.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.433
LOC111145671	LOC111142438	A0A2Y9JFB7	A0A2Y9ISJ5	Neurogenic locus notch homolog protein 1.	Mothers against decapentaplegic homolog.	0.432