(59 nodes) Positive regulation of phosphatidylinositol 3-kinase signaling network (Enhydra lutris)

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Known Interactions

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Predicted Interactions

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protein homology

Your Input:
	LOC111148319	Proteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	LOC111148788	Serpin A12; Belongs to the serpin family. (414 aa)
	LOC111147513	Trem-like transcript 1 protein isoform X1. (312 aa)
	LOC111149799	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
	LOC111161581	Hematopoietic cell signal transducer. (79 aa)
	LOC111149991	Proline-rich protein 5-like. (368 aa)
	LOC111147839	Triggering receptor expressed on myeloid cells 2. (230 aa)
	LOC111150279	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (109 aa)
	LOC111149443	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (531 aa)
	LOC111150631	Myocilin. (491 aa)
	LOC111150760	P-selectin isoform X1. (911 aa)
	LOC111149192	Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa)
	LOC111151979	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	LOC111152589	Tyrosine-protein kinase receptor. (863 aa)
	LOC111152643	Tyrosine-protein kinase receptor. (1367 aa)
	LOC111151068	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	LOC111153622	Tyrosine-protein kinase transmembrane receptor ROR2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (953 aa)
	LOC111153783	Platelet-derived growth factor D isoform X1. (370 aa)
	LOC111160020	oncostatin-M. (237 aa)
	LOC111153506	Tyrosine-protein kinase transmembrane receptor ROR2-like; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1075 aa)
	LOC111153493	semaphorin-4D; Belongs to the semaphorin family. (974 aa)
	LOC111152110	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
	LOC111153271	E3 ubiquitin-protein ligase NEDD4 isoform X1. (1323 aa)
	LOC111161912	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (920 aa)
	LOC111143733	Fibronectin isoform X1. (2476 aa)
	LOC111144693	Phosphoinositide 3-kinase adapter protein 1 isoform X1. (805 aa)
	LOC111143305	Inactive tyrosine-protein kinase transmembrane receptor ROR1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (874 aa)
	LOC111145159	NAD-dependent protein deacetylase sirtuin-1 isoform X1. (751 aa)
	LOC111145647	G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	LOC111145187	Netrin receptor UNC5B isoform X1. (945 aa)
	LOC111145884	Platelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (211 aa)
	LOC111144043	T-cell-specific surface glycoprotein CD28. (255 aa)
	LOC111145864	Neutrophil cytosol factor 1. (389 aa)
	LOC111148068	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (693 aa)
	LOC111148419	Proteinase-activated receptor 2. (397 aa)
	LOC111161731	Myeloid-derived growth factor. (173 aa)
	LOC111159680	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
	LOC111161798	Tyrosine-protein kinase receptor. (1381 aa)
	LOC111153613	Tyrosine-protein kinase receptor. (838 aa)
	LOC111152376	Peroxisome proliferator-activated receptor delta. (441 aa)
	LOC111154940	Hematopoietic lineage cell-specific protein. (474 aa)
	LOC111155225	Reelin isoform X1. (3460 aa)
	LOC111156005	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (341 aa)
	LOC111153838	E3 ubiquitin-protein ligase CBL. (912 aa)
	LOC111155271	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
	LOC111155296	semaphorin-3E; Belongs to the semaphorin family. (775 aa)
	LOC111157465	LOW QUALITY PROTEIN: rho GTPase-activating protein 8. (501 aa)
	LOC111157574	Proline-rich protein 5 isoform X1. (389 aa)
	LOC111158583	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
	LOC111159847	Angiopoietin-1 receptor. (1124 aa)
	LOC111156657	Homeobox protein Nkx-3.1. (229 aa)
	LOC111158128	Transcription factor SOX-9 isoform X1. (510 aa)
	LOC111160516	Angiotensinogen; Belongs to the serpin family. (477 aa)
	LOC111157534	Platelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (243 aa)
	LOC111138872	Tyrosine-protein kinase receptor. (796 aa)
	LOC111138855	Receptor protein-tyrosine kinase. (1256 aa)
	LOC111138898	HCLS1-associated protein X-1 isoform X1. (315 aa)
	LOC111142130	Decorin; May affect the rate of fibrils formation. (360 aa)
	LOC111142853	Tyrosine-protein kinase. (526 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111138855	LOC111142130	A0A2Y9IH64	A0A2Y9IRB3	Receptor protein-tyrosine kinase.	Decorin; May affect the rate of fibrils formation.	0.928
LOC111138855	LOC111142853	A0A2Y9IH64	A0A2Y9IT95	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.418
LOC111138855	LOC111145884	A0A2Y9IH64	A0A2Y9J7D5	Receptor protein-tyrosine kinase.	Platelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family.	0.674
LOC111138855	LOC111149192	A0A2Y9IH64	A0A2Y9JVZ2	Receptor protein-tyrosine kinase.	Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.530
LOC111138855	LOC111150279	A0A2Y9IH64	A0A2Y9JQV6	Receptor protein-tyrosine kinase.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.769
LOC111138855	LOC111153271	A0A2Y9IH64	A0A2Y9K8H4	Receptor protein-tyrosine kinase.	E3 ubiquitin-protein ligase NEDD4 isoform X1.	0.793
LOC111138855	LOC111153783	A0A2Y9IH64	A0A2Y9K6J8	Receptor protein-tyrosine kinase.	Platelet-derived growth factor D isoform X1.	0.658
LOC111138855	LOC111153838	A0A2Y9IH64	A0A2Y9KHH6	Receptor protein-tyrosine kinase.	E3 ubiquitin-protein ligase CBL.	0.750
LOC111138855	LOC111155271	A0A2Y9IH64	A0A2Y9KI03	Receptor protein-tyrosine kinase.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.703
LOC111138855	LOC111156005	A0A2Y9IH64	A0A2Y9KEQ6	Receptor protein-tyrosine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.801
LOC111138855	LOC111157534	A0A2Y9IH64	A0A2Y9KZY4	Receptor protein-tyrosine kinase.	Platelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family.	0.677
LOC111138855	LOC111159680	A0A2Y9IH64	A0A2Y9L924	Receptor protein-tyrosine kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.587
LOC111138872	LOC111145884	A0A2Y9ID15	A0A2Y9J7D5	Tyrosine-protein kinase receptor.	Platelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family.	0.666
LOC111138872	LOC111150279	A0A2Y9ID15	A0A2Y9JQV6	Tyrosine-protein kinase receptor.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.765
LOC111138872	LOC111152589	A0A2Y9ID15	A0A2Y9K0G2	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase receptor.	0.426
LOC111138872	LOC111153783	A0A2Y9ID15	A0A2Y9K6J8	Tyrosine-protein kinase receptor.	Platelet-derived growth factor D isoform X1.	0.670
LOC111138872	LOC111155271	A0A2Y9ID15	A0A2Y9KI03	Tyrosine-protein kinase receptor.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.716
LOC111138872	LOC111156005	A0A2Y9ID15	A0A2Y9KEQ6	Tyrosine-protein kinase receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.705
LOC111138872	LOC111157534	A0A2Y9ID15	A0A2Y9KZY4	Tyrosine-protein kinase receptor.	Platelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family.	0.679
LOC111138898	LOC111154940	A0A2Y9IKM7	A0A2Y9KBU5	HCLS1-associated protein X-1 isoform X1.	Hematopoietic lineage cell-specific protein.	0.428