(51 nodes) Myotube differentiation network (Enhydra lutris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111152145	A disintegrin and metalloproteinase with thrombospondin motifs 5. (930 aa)
	LOC111150705	LOW QUALITY PROTEIN: calpain-8-like; Belongs to the peptidase C2 family. (580 aa)
	LOC111152061	LOW QUALITY PROTEIN: kell blood group glycoprotein. (873 aa)
	LOC111150995	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
	LOC111153728	Dedicator of cytokinesis protein 5; Belongs to the DOCK family. (1869 aa)
	LOC111154566	Serine/threonine-protein phosphatase. (521 aa)
	LOC111152017	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
	LOC111154714	Selenoprotein N. (565 aa)
	LOC111153834	Cell adhesion molecule-related/down-regulated by oncogenes. (1260 aa)
	LOC111153887	A disintegrin and metalloproteinase with thrombospondin motifs 15. (969 aa)
	LOC111155558	Integrin beta; Belongs to the integrin beta chain family. (801 aa)
	LOC111155854	Fer-1-like protein 5. (2101 aa)
	LOC111155950	Transmembrane protein 182. (229 aa)
	LOC111153683	Bridging integrator 3. (319 aa)
	LOC111157043	Kelch-like protein 41. (606 aa)
	LOC111158015	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	LOC111159054	Kelch-like protein 40. (624 aa)
	LOC111157990	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	LOC111159754	Tetraspanin. (226 aa)
	LOC111160159	LOW QUALITY PROTEIN: SH3 and cysteine-rich domain-containing protein 3. (364 aa)
	LOC111162069	Pleckstrin homology domain-containing family O member 1. (408 aa)
	LOC111160157	R3H domain-containing protein 2 isoform X1. (1072 aa)
	LOC111161538	Dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1. (756 aa)
	LOC111161575	Nephrin isoform X1. (1244 aa)
	LOC111144797	Serine/threonine-protein phosphatase. (534 aa)
	LOC111143680	Delta and Notch-like epidermal growth factor-related receptor. (740 aa)
	LOC111144224	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	LOC111143529	Prostaglandin F2 receptor negative regulator. (902 aa)
	LOC111141582	LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2. (912 aa)
	LOC111140624	Homeobox protein SIX4. (784 aa)
	LOC111139780	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (475 aa)
	LOC111138641	Rho family-interacting cell polarization regulator 2 isoform X1. (1085 aa)
	LOC111140871	Dedicator of cytokinesis protein 2; Belongs to the DOCK family. (1829 aa)
	LOC111140662	Protein TANC1. (1843 aa)
	LOC111140645	Spatacsin isoform X1. (2444 aa)
	LOC111143153	Sortilin. (831 aa)
	LOC111145075	Dedicator of cytokinesis protein 1 isoform X1; Belongs to the DOCK family. (1889 aa)
	LOC111145054	Myoferlin isoform X1. (2061 aa)
	LOC111145986	Uncharacterized family 31 glucosidase KIAA1161 homolog; Belongs to the glycosyl hydrolase 31 family. (714 aa)
	LOC111146445	Protein myomaker. (221 aa)
	LOC111145987	Spermatid-specific manchette-related protein 1. (298 aa)
	LOC111147073	Krueppel-like factor 5. (457 aa)
	LOC111147840	Uncharacterized LOC101929726 homolog. (84 aa)
	LOC111148296	Homer protein homolog 1. (354 aa)
	LOC111148595	Alpha-actinin-1 isoform X1. (914 aa)
	LOC111148445	Myocyte-specific enhancer factor 2C isoform X1. (483 aa)
	LOC111149456	Tetraspanin. (236 aa)
	LOC111150685	Calpain-2 catalytic subunit; Belongs to the peptidase C2 family. (700 aa)
	LOC111150871	Histone-lysine N-methyltransferase SMYD3. (428 aa)
	LOC111150290	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
	LOC111151976	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111138641	LOC111139780	A0A2Y9IJZ9	A0A2Y9IKQ2	Rho family-interacting cell polarization regulator 2 isoform X1.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.422
LOC111139780	LOC111138641	A0A2Y9IKQ2	A0A2Y9IJZ9	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	Rho family-interacting cell polarization regulator 2 isoform X1.	0.422
LOC111140624	LOC111150290	A0A2Y9IRA1	A0A2Y9JVB7	Homeobox protein SIX4.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.457
LOC111140871	LOC111155558	A0A2Y9IJG3	A0A2Y9KDC5	Dedicator of cytokinesis protein 2; Belongs to the DOCK family.	Integrin beta; Belongs to the integrin beta chain family.	0.448
LOC111141582	LOC111144797	A0A2Y9IVG8	A0A2Y9J295	LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2.	Serine/threonine-protein phosphatase.	0.963
LOC111141582	LOC111148445	A0A2Y9IVG8	A0A2Y9JM62	LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2.	Myocyte-specific enhancer factor 2C isoform X1.	0.910
LOC111141582	LOC111154566	A0A2Y9IVG8	A0A2Y9K915	LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2.	Serine/threonine-protein phosphatase.	0.966
LOC111143529	LOC111149456	A0A2Y9IXF4	A0A2Y9JMD1	Prostaglandin F2 receptor negative regulator.	Tetraspanin.	0.760
LOC111143529	LOC111159754	A0A2Y9IXF4	A0A2Y9KWC8	Prostaglandin F2 receptor negative regulator.	Tetraspanin.	0.808
LOC111144224	LOC111145054	A0A2Y9IZS5	A0A2Y9J6P8	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Myoferlin isoform X1.	0.493
LOC111144224	LOC111150290	A0A2Y9IZS5	A0A2Y9JVB7	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.455
LOC111144224	LOC111151976	A0A2Y9IZS5	A0A2Y9JXS7	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.990
LOC111144224	LOC111155558	A0A2Y9IZS5	A0A2Y9KDC5	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Integrin beta; Belongs to the integrin beta chain family.	0.709
LOC111144224	LOC111155854	A0A2Y9IZS5	A0A2Y9KER2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Fer-1-like protein 5.	0.493
LOC111144797	LOC111141582	A0A2Y9J295	A0A2Y9IVG8	Serine/threonine-protein phosphatase.	LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2.	0.963
LOC111144797	LOC111154566	A0A2Y9J295	A0A2Y9K915	Serine/threonine-protein phosphatase.	Serine/threonine-protein phosphatase.	0.953
LOC111145054	LOC111144224	A0A2Y9J6P8	A0A2Y9IZS5	Myoferlin isoform X1.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.493
LOC111146445	LOC111147840	A0A2Y9J9P8	A0A2Y9JGU1	Protein myomaker.	Uncharacterized LOC101929726 homolog.	0.511
LOC111146445	LOC111150290	A0A2Y9J9P8	A0A2Y9JVB7	Protein myomaker.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.426
LOC111146445	LOC111150995	A0A2Y9J9P8	A0A2Y9K3Y6	Protein myomaker.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.513