(15 nodes) Male sex determination network (Enhydra lutris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111151101	Nuclear receptor subfamily 5 group A member 2 isoform X1. (541 aa)
	LOC111150569	Nuclear receptor subfamily 0 group B member 1. (471 aa)
	LOC111149452	LOW QUALITY PROTEIN: splicing factor 1. (670 aa)
	LOC111147022	Transcription factor SOX-1. (393 aa)
	LOC111146254	Steroidogenic factor 1. (461 aa)
	LOC111138871	Tyrosine-protein kinase receptor. (1300 aa)
	LOC111140196	Nuclear receptor subfamily 0 group B member 2-like. (279 aa)
	LOC111140624	Homeobox protein SIX4. (784 aa)
	LOC111158000	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
	LOC111159933	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	LOC111158128	Transcription factor SOX-9 isoform X1. (510 aa)
	LOC111158979	Transcription factor SOX-3 isoform X1. (445 aa)
	LOC111158665	Mitogen-activated protein kinase kinase kinase 4. (1605 aa)
	LOC111153656	Doublesex- and mab-3-related transcription factor 1. (374 aa)
	LOC111151025	Transcription factor SOX-2. (321 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111138871	LOC111159933	A0A2Y9ICT6	A0A2Y9KZ18	Tyrosine-protein kinase receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.675
LOC111140196	LOC111146254	A0A2Y9ILM9	A0A2Y9JHY0	Nuclear receptor subfamily 0 group B member 2-like.	Steroidogenic factor 1.	0.616
LOC111140196	LOC111151101	A0A2Y9ILM9	A0A2Y9JYJ0	Nuclear receptor subfamily 0 group B member 2-like.	Nuclear receptor subfamily 5 group A member 2 isoform X1.	0.616
LOC111146254	LOC111140196	A0A2Y9JHY0	A0A2Y9ILM9	Steroidogenic factor 1.	Nuclear receptor subfamily 0 group B member 2-like.	0.616
LOC111146254	LOC111147022	A0A2Y9JHY0	A0A2Y9JDD2	Steroidogenic factor 1.	Transcription factor SOX-1.	0.486
LOC111146254	LOC111150569	A0A2Y9JHY0	A0A2Y9JRW6	Steroidogenic factor 1.	Nuclear receptor subfamily 0 group B member 1.	0.973
LOC111146254	LOC111151025	A0A2Y9JHY0	A0A2Y9JY45	Steroidogenic factor 1.	Transcription factor SOX-2.	0.486
LOC111146254	LOC111158128	A0A2Y9JHY0	A0A2Y9KWM5	Steroidogenic factor 1.	Transcription factor SOX-9 isoform X1.	0.647
LOC111146254	LOC111158979	A0A2Y9JHY0	A0A2Y9KSR0	Steroidogenic factor 1.	Transcription factor SOX-3 isoform X1.	0.486
LOC111147022	LOC111146254	A0A2Y9JDD2	A0A2Y9JHY0	Transcription factor SOX-1.	Steroidogenic factor 1.	0.486
LOC111147022	LOC111151101	A0A2Y9JDD2	A0A2Y9JYJ0	Transcription factor SOX-1.	Nuclear receptor subfamily 5 group A member 2 isoform X1.	0.486
LOC111147022	LOC111153656	A0A2Y9JDD2	A0A2Y9KGM2	Transcription factor SOX-1.	Doublesex- and mab-3-related transcription factor 1.	0.424
LOC111147022	LOC111159933	A0A2Y9JDD2	A0A2Y9KZ18	Transcription factor SOX-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.403
LOC111150569	LOC111146254	A0A2Y9JRW6	A0A2Y9JHY0	Nuclear receptor subfamily 0 group B member 1.	Steroidogenic factor 1.	0.973
LOC111150569	LOC111151101	A0A2Y9JRW6	A0A2Y9JYJ0	Nuclear receptor subfamily 0 group B member 1.	Nuclear receptor subfamily 5 group A member 2 isoform X1.	0.749
LOC111151025	LOC111146254	A0A2Y9JY45	A0A2Y9JHY0	Transcription factor SOX-2.	Steroidogenic factor 1.	0.486
LOC111151025	LOC111151101	A0A2Y9JY45	A0A2Y9JYJ0	Transcription factor SOX-2.	Nuclear receptor subfamily 5 group A member 2 isoform X1.	0.486
LOC111151025	LOC111153656	A0A2Y9JY45	A0A2Y9KGM2	Transcription factor SOX-2.	Doublesex- and mab-3-related transcription factor 1.	0.424
LOC111151025	LOC111159933	A0A2Y9JY45	A0A2Y9KZ18	Transcription factor SOX-2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.403
LOC111151101	LOC111140196	A0A2Y9JYJ0	A0A2Y9ILM9	Nuclear receptor subfamily 5 group A member 2 isoform X1.	Nuclear receptor subfamily 0 group B member 2-like.	0.616